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| 1 | 介绍一种新的具有重要临床意义的浸润性子宫颈管腺癌分类系统显示文摘最近,新子宫颈管腺癌分类系统被提出。该系统将肿瘤分为三型。A型:肿瘤常由界限清楚的呈巢、簇状腺体排列的小叶状结构;B型:肿瘤表现为局部破坏性浸润,显示促纤维增生间质围绕不规则或边界不清或不完整的腺体,间质中散在单个或小簇状肿瘤细胞;C型:肿瘤表现为弥漫浸润性生长,伴广泛的促纤维间质反应。 | Roma A A Diaz De Vivar A Park K J 康锶鹏 余英豪 | 2015 | 临床与实验病理学杂志2015，31，11： | 17 |
| 2 | Dynamic localization of hepatocellular transporters in health and disease显示文摘Vesicle-based traffi cking of hepatocellular transporters involves delivery of the newly-synthesized carriers from the rough endoplasmic reticulum to either the plasma membrane domain or to an endosomal,submembrane compartment,followed by exocytic targeting to the plasma membrane. Once delivered to the plasma membrane,the transporters usually undergo recycling between the plasma membrane and the endosomal compartment,which usually serves as a reservoir of pre-existing transporters available on demand. The balance between exocytic targeting and endocytic internalization from/to this recycling compartment is therefore a chief determinant of the overall capability of the liver epithelium to secrete bile and to detoxify endo and xenobiotics. Hence,it is a highly regulated process. Impaired regulation of this balance may lead to abnormal localization of these transporters,which results in bile secretory failure due to endocytic internalization of key transporters involved in bile formation. This occurs in several experimental models of hepatocellular cholestasis,and in most human cholestatic liver diseases. This review describes the molecular bases involved in the biology of the dynamic localization of hepatocellular transporters and its regulation,with a focus on the involvement of signaling pathways in this process. Their alterations in different experimental models of cholestasis and in human cholestatic liver disease are reviewed. In addition,the causes explaining the pathological condition (e.g. disorganization of actin or actin-transporter linkers) and the mediators involved (e.g. activation of cholestatic signaling transduction pathways) are also discussed. Finally,several experimental therapeutic approaches based upon the administration of compounds known to stimulate exocytic insertion of canalicular transporters (e.g. cAMP,tauroursodeoxycholate) are described. | Marcelo G Roma Fernando A Crocenzi Aldo D Mottino | 2008 | World Journal of Gastroenterology2008，14，44： | 2 |
| 3 | Andean foothills structures in northern Magallanes basin, Argentina 显示文摘 | Romas V A | 1989 | AAPG Bull1989，73，： | 1 |
| 4 | Integrin be-ta2-chain (CD18 ) over-expression on CD4+ T cells andmonocytes after ischemia/ reperfusion in patients undergo-ing primary percutaneous revascularization 显示文摘 | Sardella G Accapezzato D Di Roma A | 2003 | Int J Im-mun Pharmacol2003，17，2： | 1 |
| 5 | Integrin beta2-chain (CD18) over-expression on CD4+ T cells and monocytes after ischemia/reperfusion in patients undergoing primary percutaneous revascularization显示文摘 | Sardella G Accapezzato D Di Roma A | 2004 | Int J Immunopathol Pharmacol2004，17，2： | 1 |
| 6 | Diagnostic value of hysterosalpingography in the detection of intrauterine abnormalities:a comparison with hysteroscopy显示文摘 | Roma DalfóA Ubeda B Ubeda A | 2004 | AJR Am J Roentgenol2004，183，5： | 1 |
| 7 | Diagnostic value of hysterosalpingography in the detection of intrauterine abnormalities:a comparison with hysteroscopy显示文摘 | Roma Dalfo A Ubeda A | 2004 | Am J Roentgenol2004，183，5： | 1 |
| 8 | The distinction of bronchogenic cyst from metastatic testicular teratoma: a light microscopic and immunohistochemical study 显示文摘 | Roma A Varsegi M Magi-Galluzzi C | 2008 | Am J Clin Pathol2008，130，2： | 1 |
| 9 | Smooth stress relief of trifluoroacetate metal-organic solutions for YBa2 Cu3 O7 film growth显示文摘 | Zalamova K Roma N Pomar A | 2006 | Chem Mater2006，18，： | 1 |
| 10 | Diagnostic value of hysterosalpingography in the detection of intrauterine abnormalities: a comparison with hysteroscopy显示文摘 | Roma Dalfo A Ubeda B Ubeda A | 2004 | American Journal of Roentgenology2004，183，5： | 1 |
| 11 | Fast calcination of purified trifluoroacetate metal-organic precursors for high critical current YBa2 Cu3 O7 thin films显示文摘 | Zalamova K Roma N Pomar A | 2006 | Physica C2006，43，： | 1 |
| 12 | Criteria for recognition of hydrothermal mineral deposits in ocean crust 显示文摘 | Roma P A | 1987 | Ecomomic Geology1987，73，2： | 1 |
| 13 | lntegrin beta2-chain (CDI8) over-expression on CD4+ T cells and monocytes after ischemia/reperfusion in patients undergoing primary percutaneous revascularization 显示文摘 | Sardella G Aeeapezzato D Di Roma A | 2004 | Int J Immunopathol Pharmacol2004，17，2： | 1 |
| 14 | Cancer-induced hypercalcemia 显示文摘 | Lumachi F Brunello A Roma A | 2009 | Anticancer Res2009，29，5： | 1 |
| 15 | First-Line sunitinib in patients with renal cell carcinoma (RCC) in von Hippel-Lindau (VHL) disease : clinical outcome and patterns of radiological response 显示文摘 | Roma A Maruzzo M Basso U | 2015 | Fam Cancer2015，14，2： | 1 |
| 16 | Evolution of pathological changes in the gastrocnemius of the mdx mice correlate with utrephin and beta-dystroglycan expression显示文摘 | Roma J Munell F Fargas A | 2004 | Acta Nenropathol (Berl)2004，108，5： | 1 |
| 17 | The usefulness of immunohistochemical markers in the differential diagnosis of renal neoplasms显示文摘 | Zhou M Roma A Magi-Galluzzi C | | 0，，02： | 1 |
| 18 | Chemotherapy and targeted agents for elderly women with advanced breast cancer显示文摘 | Brunello A Roma A Falci C | 2008 | Recent Pat Anticancer Drug Discov2008，3，3： | 1 |
| 19 | Integrin beta2-chain (CD18) over-expression on CD4 + T cells and monocytes after ischemia/reperfusion in patients undergoing primary percutaneous revascularization 显示文摘 | Sat'della G Accapezzato D Di Roma A | 2004 | Int J Immunopathol Pharmacol2004，17，2： | 1 |
| 20 | Integrin beta2- on CD4 ~ Tcells and monocytes patients undergoing primary percutaneous revascularization 显示文摘 | Sardella G Accapezzato D Di chain ( CDIs ) over-expression afterischemia/reperfusion in Roma A | 2004 | Int J Immunopathol Pharmacol2004，17，2： | 1 |
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