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| 1 | Adenosquamous carcinoma of the pancreas: Molecular characterization of 23 patients along with a literature review显示文摘Adenosquamous carcinoma of the pancreas(ASCP)is a rare entity. Like adenocarcinoma of the pancreas,overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of ASCP.Molecular characterization revealed overexpression in MRP1(80%), MGMT(79%), TOP2A(75), RRM1(42%),TOPO1(42%), PTEN(45%), CMET(40%), and C-KIT(10%) among others. One hundred percent of samples tested were positive for KRAS mutations. This analysis shows heretofore unsuspected leads to be considered for treatments of this rare type of exocrine pancreas cancer. Molecular profiling may be appropriate to provide maximum information regarding the patient's tumor. Further work should be pursued to better characterize this disease. | Erkut Borazanci Sherri Z Millis Ron Korn Haiyong Han Clifford J Whatcott Zoran Gatalica Michael T Barrett Derek Cridebring Daniel D Von Hoff | 2015 | World Journal of Gastrointestinal Oncology2015，7，9： | 6 |
| 2 | Constant serum levels of secreted asialoglycoprotein receptor sH2a and decrease with cirrhosis显示文摘AIM: To investigate the existence and levels of sH2a, a soluble secreted form of the asialoglycoprotein receptor in human serum. METHODS: Production of recombinant sH2a and development of a monoclonal antibody and an enzyme-linked immunosorbent assay (ELISA). This assay was used to determine the presence and concentration of sH2a in human sera of individuals of both sexes and a wide range of ages. RESULTS: The recombinant protein was produced successfully and a specific ELISA assay was developed. The levels of sH2a in sera from 62 healthy individuals variedminimally (147 ± 19 ng/mL). In contrast, 5 hepatitis C patients with cirrhosis showed much decreased sH2a levels (50 ± 9 ng/mL). CONCLUSION: Constant sH2a levels suggest constitutive secretion from hepatocytes in healthy individuals. This constant level and the decrease with cirrhosis suggest a diagnostic potential. | Ron Benyair Maria Kondratyev Elena Veselkin Sandra Tol-chinsky Marina Shenkman Yoav Lurie Gerardo Z Lederkremer | 2011 | World Journal of Gastroenterology2011，17，48： | 3 |
| 3 | Natural Role of Biosurfactants显示文摘 | RON E Z ROSENBERG E | 2001 | Environ Microbiol2001，3，4： | 1 |
| 4 | Host specificity of septicemic Escherichia coli : Human and avian pathogens 显示文摘 | Ron R Z | 2006 | Current Opinions in Microbiology2006，9，： | 1 |
| 5 | Self-assembled fmoc-peptides as a platform for the formation of nanostructures and hydrogels 显示文摘 | Ron O Lihi A A Sivan Z | 2009 | Biomacromolecules2009，10，9： | 1 |
| 6 | Safety and efficacy of the vi- brating capsule, an innovative non-pharmacological treatment mo- dality for chronic constipation 显示文摘 | Ron Y Halpem Z Safadi R | 2015 | Neurogastroenterol Motil2015，27，1： | 1 |
| 7 | Block Rotation by Strike-Slip Faulting z Structural and Paleomagnetic Evidence 显示文摘 | Ron H Freund R Garfunkel Z | 1984 | Journal of Geophysical Research1984，89，： | 1 |
| 8 | Bioemulsans:microbial polymeric emulsi-fiers显示文摘 | ROSENBERG E RON Z E | 1997 | Current Opinion in Biotechnology1997，8，： | 1 |
| 9 | Affine systems in L2(R^d) : the analysis of the analysis operator显示文摘 | Ron A Shen Z | 1997 | Funct Anal1997，148，2： | 1 |
| 10 | Affine systems in L2 (Rd), the analysis of the analysis operator 显示文摘 | RON A SHEN Z | 1997 | Funct Anal1997，148，2： | 1 |
| 11 | Amperometric quantification of total coliforms and specific detection of Escherichia coli显示文摘 | Mittelmann A S Ron E Z Rishpon J | 2002 | Analytical Chemistry2002，74，4： | 1 |
| 12 | Biosurfactants and oil bioremediation显示文摘 | Eliora Z Ron Eugene R | 2002 | Current Opinion in Bitechnology2002，13，： | 1 |
| 13 | Acromegaly and gastrointestinal cancer显示文摘 | Ron E Gridley G Hrubec Z | 1991 | Cancer1991，68，： | 1 |
| 14 | Affine Systems in L2 (Ra) the Analysis of the Analysis Operator 显示文摘 | Ron A Shen Z | 1997 | Journal of Functional Analysis1997，148，2： | 1 |
| 15 | Biosurfactants and oil bioremediation 显示文摘 | Ron E Z Rosenberg E | 2002 | Current Opbion in Biotechnology2002，13，3： | 1 |
| 16 | High -and low-molecular-mass microbial surfactants显示文摘 | Rosenberg E Ron E Z | 1999 | Applied Microbiology and Biotechnology1999，52，： | 1 |
| 17 | Adaptation of Escherichi coli to elevated temperatures involves a change in stability of heat shock gene transcripts 显示文摘 | Shenhar Y Rasouly A Biran D Eliora Z Ron | 2009 | Environmental Microbiology2009，11，12： | 1 |
| 18 | Compactly supported tight affine spline frames in L2(R^d)显示文摘 | Ron A Shen Z | 1998 | Math Comp1998，67，： | 1 |
| 19 | Host specificity of septicemic Escherichia coli: human and avian pathogens显示文摘 | Ron E Z | 2006 | Curr Opin Microbiol2006，9，1： | 1 |
| 20 | Affine system in L2 (Rd ): the analysisof the analysis operator 显示文摘 | RON A SHEN Z | 1997 | J Funct Anal1997，148，2： | 1 |
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