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| 1 | Imaging response predictors following drug eluting beads chemoembolization in the neoadjuvant liver transplant treatment of hepatocellular carcinoma显示文摘BACKGROUND Drug-eluting bead transarterial chemoembolization(DEB-TACE)is an endovascular treatment to release chemotherapeutic agents within a target lesion,minimizing systemic exposure and adverse effects to chemotherapeutics.Therefore,identifying which patient characteristics may predict imaging response to DEB-TACE can improve treatment results while selecting the best candidates.Predictors of the response after DEB-TACE still have not been fully elucidated.This is the first prospective study performed with standardized DEBTACE technique that aim to identify predictors of radiological response,assessing patients clinical and laboratory characteristics,diagnostic imaging and intraprocedure data of the hepatocellular carcinoma treated in the neoadjuvant context for liver transplantation.AIM To identify pre-and intraoperative clinical and imaging predictors of the radiological response of drug-eluting bead transarterial chemoembolization(DEB-TACE)for the neoadjuvant treatment of hepatocellular carcinoma(HCC).METHODS This is prospective,cohort study,performed in a single transplant center,from 2011 to 2014.Consecutive patients with HCC considered for liver transplant who underwent DEB-TACE in the first session for downstaging or bridging purposes were recruited.Pre and post-chemoembolization imaging studies were performed by computed tomography or magnetic resonance.The radiological response of each individual HCC was evaluated by objective response using mRECIST and the percentage of necrosis.RESULTS Two hundred patients with 380 HCCs were examined.Analysis of the objective response(nodule-based analysis)demonstrated that HCC with pseudocapsules had a 2.01 times greater chance of being responders than those without pseudocapsules(P=0.01),and the addition of every 1mg of chemoembolic agent increased the chance of therapeutic response in 4%(P<0.001).Analysis of the percentage of necrosis through multiple linear regression revealed that the addition of each 1mg of the chemoembolic agent caused an average increase of 0.65%(P<0.001)in necrosis in the treated lesion,whereas the hepatocellular carcinoma with pseudocapsules presented 18.27%(P<0.001)increased necrosis compared to those without pseudocapsules.CONCLUSION The presence of a pseudocapsule and the addition of the amount of chemoembolic agent increases the chance of an objective response in hepatocellular carcinoma and increases the percentage of tumor necrosis following drug-eluting bead chemoembolization in the neoadjuvant treatment,prior to liver transplantation. | Francisco Leonardo Galastri Felipe Nasser Breno Boueri Affonso Leonardo Guedes Moreira Valle Bruno Calazans Odísio Joaquim Mauricio Motta-Leal Filho Paolo Rogério Salvalaggio Rodrigo Gobbo Garcia Márcio Dias de Almeida Ronaldo Hueb Baroni Nelson Wolosker | 2020 | World Journal of Hepatology2020，12，1： | 2 |
| 2 | Non-pharmacological management of pediatric functional abdominal pain disorders:Current evidence and future perspectives显示文摘Functional abdominal pain disorders(FAPDs) are an important and prevalent cause of functional gastrointestinal disorders among children, encompassing the diagnoses of functional dyspepsia, irritable bowel syndrome, abdominal migraine, and the one not previously present in Rome Ⅲ, functional abdominal pain not otherwise specified. In the absence of sufficiently effective and safe pharmacological treatments for this public problem, non-pharmacological therapies emerge as a viable means of treating these patients, avoiding not only possible side effects, but also unnecessary prescription, since many of the pharmacological treatments prescribed do not have good efficacy when compared to placebo. Thus, the present study provides a review of current and relevant evidence on non-pharmacological management of FAPDs, covering the most commonly indicated treatments, from cognitive behavioral therapy to meditation, acupuncture, yoga, massage, spinal manipulation, moxibustion, and physical activities. In addition, this article also analyzes the quality of publications in the area, assessing whether it is possible to state if non-pharmacological therapies are viable, safe, and sufficiently well-based for an appropriate and effective prescription of these treatments. Finally, it is possible to observe an increase not only in the number of publications on the non-pharmacological treatments for FAPDs in recent years, but also an increase in the quality of these publications. Finally, the sample selection of satisfactory age groups in these studies enables the formulation of specific guidelines for this age group, thus avoiding the need for adaptation of prescriptions initially made for adults, but for children use. | Maria Luísa Cordeiro Santos Ronaldo Teixeira da Silva Júnior Breno Bittencourt de Brito Filipe Antônio França da Silva Hanna Santos Marques Vinícius Lima de SouzaGonçalves Talita Costa dos Santos Carolina Ladeia Cirne Natália Oliveira e Silva Márcio Vasconcelos Oliveira Fabrício Freire de Melo | 2022 | World Journal of Clinical Pediatrics2022，11，2： | 2 |
| 3 | Ultrafast synthesis and sintering of materials in a single running experiment approach by using electric fields显示文摘Processing of materials in the form of ceramics normally involves several steps including calcination at a relatively low temperature for synthesis of the end-product powder and sintering at a high temperature for densification.The work we have been developing introduces a novel approach enabling synthesis plus sintering of materials in a single running experiment by using electric fields,ending with dense ceramics that display grains noticeably finer than in conventional processing.This new paradigm is fully illustrated with experiments conducted on amorphous CaCu3Ti4O12 precursor powder,shown to experience,on heating,crystallization through intermediate phases,followed by chemical reaction leading to synthesis of the end-product powder,plus densification depending on field adjustment.The processing time and furnace temperature are considerably reduced,demonstrating that enhanced synthesis and sintering rates applied under field input.Similar results found in Bi2/3Cu3Ti4O12are also shown.The different factors that may contribute to this unique scenario,including Joule heating,defect generation,and reduction of free energy for nuclei formation promoted by the applied field,are briefly discussed.Overall,the findings we bring here are exclusive as they show an exploitable way that allows rapid processing of materials with good control over particle and grain coarsening. | Lílian M.JESUS Ronaldo S.SILVA Jean-Claude M’PEKO | 2019 | Journal of Advanced Ceramics2019，8，2： | 2 |
| 4 | Case Studies for SelfOrganization in Computer Science 显示文摘 | Mamei M Ronaldo M Zambonelli F | 2006 | Journal of Systems Architecture2006，52，8： | 1 |
| 5 | Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice显示文摘 | Ronaldo A Ribeiro Mariana L Vale Sara M Thomazzi Adriana B.P Paschoalato Steve Poole Sergio H Ferreira Fernando Q Cunha | 2000 | European Journal of Pharmacology2000，，1： | 1 |
| 6 | Nuclear plant requirements during power system restoration 显示文摘 | M M Adibi Gerry AdArmki Ronaldo JenklnA | 1995 | IEEE Trans on Power Systems1995，10，3： | 1 |
| 7 | A study of the behavior of several methods for balancing machine learning training data显示文摘 | Gustavo E A P A B Ronaldo C P Monard M C | 2004 | ACM Special Interest Group on Knowledge Discovery and Data Mining (SIGKDD)2004，6，1： | 1 |
| 8 | Nuclear magnetic resonance and water activity in measuring the water mobility in Pintato fish 显示文摘 | Ronaldo N M Pitombo Guilherme A M R Lima | 2003 | Journal of Food Engineering2003，58，： | 1 |
| 9 | Fatigue life estimates for a slender orthotropic steel deck 显示文摘 | Ronaldo C Battista Michele S Pfeil Eliane M L Carvalho | 2008 | Journal of Constructional Steel Research2008，64，： | 1 |
| 10 | Effect of salinity on the osmotic chloride, total protein and calcium concentrations in the hemolymph of the prawn Peneaus monodon (Fabricius) 显示文摘 | Ronaldo P Fe D Jocelyn M | 1986 | Comp Biochemical Physiology1986，83，4： | 1 |
| 11 | 显示文摘 | Luis da S Z Ronaldo D M Rogerio | 2002 | Vacuum2002，65，： | 1 |
| 12 | Knowledge management tools, inter-organizational relationships, in- novation and firm performance显示文摘 | Antonino V Ronaldo P Francisco M V | 2010 | Technological Fore- casting and Social Change2010，77，7： | 1 |
| 13 | Prediction of the working parameters of a wood waste gasifier through an equilibrium model显示文摘 | Carlos R Altafini Paulo R Wander Ronaldo M Barreto | 2003 | Energy Conversion and Management2003，44，17： | 1 |
| 14 | Cholecalciferol modulates plasma phosphate but not plasma vitamin D levels and intesti- nal phosphate absorption in rainbow trout (Oncorhyrwhus mykiss ) 显示文摘 | Enrique M A Sandra P B Ronaldo P F | 1999 | Gen Comp EndocrinoI1999，114，： | 1 |
| 15 | An AS-level overlay network for IP traceback 显示文摘 | Andre Castelucio Artur Ziviani Ronaldo M | 2009 | IEEE Network2009，23，1： | 1 |
| 16 | Differential effects of anti-Nogo-A antibody treatment and treadmill training in rats with incomplete spinal cord injury显示文摘 | Irin C Ronaldo M Ichiyama | 2009 | Brain2009，132，： | 1 |
| 17 | High altitude exposure impairs sleep patterns, mood, and cognitive functions 显示文摘 | VALDIR D A L HANNA K M A RONALDO V T D S etal | 2012 | Psychophysiology2012，49，9： | 1 |
| 18 | Differential effects of anti-Nogo- Aantibody treatment and treadmill training in rats with incomplete spinal cord injury显示文摘 | Ifin C Ronaldo M Ichiyama | 2009 | Brain2009，132，17： | 1 |
| 19 | Aging and oxidative stress 显示文摘 | Virginia B C J Silvia B M B Sandra S C Luciano R Leandro G Ronaldo L A Guilherme P D | 2004 | Molecular Aspects of Medicine2004，25，： | 1 |
| 20 | The zeta potential and surface properties of asphaltenes obtained with different crude oil/n-heptane proportions显示文摘 | PARRA-BARRAZA H HERNANDEZ-MONTIEL D LIZARDI J HERNANDEZ J RONALDO H U VALDEZ M A | 2003 | Fuel2003，82，8： | 1 |
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