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| 1 | A long-form α-neurotoxin from cobra venom produces potent opioid-independent analgesia显示文摘Aim:In light of the antinociceptive activity of the short-chain neurotoxin,cobrotoxin,and other acetylcholine antagonists,the antinociceptive activity andmechanisms of cobratoxin(CTX),a long-chain postsynaptic α-neurotoxin,wasinvestigated in rodent pain models.Methods:CTX was administered intraperito-neally(30,45,68 μg/kg),intra-cerebral ventricularly(4.5 μg/kg)or microinjectedinto periaqueductal gray(PAG;4.5 μg/kg).The antinociceptive action was testedusing the hot-plate and acetic acid writhing tests m mice and rats.The involve-ment of the cholinergic system and opioid system in CTX-induced analgesia wasexamined by pretreatment of animals with atropine(0.5 mg/kg,im;or 10 mg/kg,ip)or naloxone(1 and 5 mg/kg,ip).The effect of CTX on motor activity was testedusing the Animex test.Results:CTX exhibited a dose-dependent analgesic ac-tion in mice as determined by both the hot-plate and acetic acid writhing tests.The peak effect of analgesia was seen 3 h after administration.In the mouse aceticacid writhing test,the intra-cerebral ventricular administration of CTX at 4.5 μg/kg(1/12th of a systemic dose)produced marked analgesic effects.Microinjection ofCTX(4.5 μgkg)into the PAG region did not elicit an analgesic action in rats in thehot-plate test.Atropine at 0.5 mg/kg(im)and naloxone at 1 and 5 mg/kg(ip)bothfailed to block the analgesic effects of CTX,but atropine at 10 mg/kg(ip)didantagonize the analgesia mediated by CTX in the mouse acetic acid writhing test.Acetylsalicylic acid(300 mg/kg)did not enhance the analgesic effects of CTX.Atthe highest effective dose of 68 μg/kg the neurotoxin did not change the sponta-neous mobility of mice.Conclusion:CTX has analgesic effects,which are medi-ated in the central nervous system though not through the PAG.The centralcholinergic system but not opioid system appears to be involved in theantinociceptive action of CTX. | Zhi-xin CHEN Hui-ling ZHANG Zhen-lun GU Bo-wen CHEN Rong HAN Paul F REID Laurence N RAYMOND Zheng-hong QIN | 2006 | Acta Pharmacologica Sinica2006，27，4： | 7 |
| 2 | Suppression of complete Freund's adjuvant-induced adjuvant arthritis by cobratoxin显示文摘 | Yan-li LIU Hai-ming LIN Rong ZOU Jun-chao WU Rong HAN Laurence N RAYMOND Paul F REID Zheng-hong QIN | 2009 | Acta Pharmacologica Sinica2009，30，2： | 6 |
| 3 | Numerical modeling of arc root transfer during contact opening in a low voltage air circuit breaker 显示文摘 | YI W RONG M Z YANG F | 2008 | IEEE Transactions2008，，： | 1 |
| 4 | CT scan directed transbronchial needle aspiration biopsy for mediastinal nodes显示文摘 | Rong F Cui B | 1998 | Chest1998，114，： | 1 |
| 5 | Ligands Dominate Highly Syndioselective Polymerization of Styrene by Using Constrained-geometry-configuration Rare-earth Metal Precursors显示文摘 | Pan Y P Rong W F Cui D M | | 0，，03： | 1 |
| 6 | The formulation of aptamer-coated paclitaxel-polylactide nanoconjugates and their targeting to cancer cells 显示文摘 | Rong T Linda Y Timothy M F | 2010 | Biomaterials2010，31，： | 1 |
| 7 | Low frequency of transgene flow from Bt/CpTI rice to its nontransgenic counterparts planted at close spacing显示文摘 | Rong J Song ZP Su J Xia H Lu BR Wang F | | 0，，： | 1 |
| 8 | Effect of grafted polymeric foaming agent on the structure and properties of nano-silica/ polypropylene composites 显示文摘 | Cai L F Huang X B Rong M Z | 2006 | Polymer2006，47，20： | 1 |
| 9 | Postischemic acute renal failure is reduced by short-term statin treatment in a rat model显示文摘 | Gueler F Rong S Park JK | 2002 | J Am Soc Nephrol2002，13，9： | 1 |
| 10 | CT scan directed transbronchial needle aspiration biopsy for mediastinal nodes 显示文摘 | Cui B | 1998 | Chest1998，114，7： | 1 |
| 11 | Statins attenuate ischemia-reper- fusion injury by inducing heme oxygenase-1 in infiltrating macro- phages显示文摘 | Gueler F Park JK Rong S | 2007 | Am J Pathol2007，170，4： | 1 |
| 12 | Hippocampal volume reduction in elderly patients at risk for postopera-tive cognitive dysfunction 显示文摘 | ChEN M H LIAO Y RONG P F | 2013 | Journal of anesthesia2013，27，4： | 1 |
| 13 | Three-dimensian surface characterization of grinding wheel using white light interferometer 显示文摘 | Yan L Rong Y M Jiang F | 2011 | International Journal of Advanced Manufacturing Technology2011，，55： | 1 |
| 14 | Myocardial apoptosis and infarction after ischemia/reperfusion are attenuated by kappa-opioid receptor agonist 显示文摘 | Rong F Peng Z Ye MX | 2009 | Arch Med Res2009，40，4： | 1 |
| 15 | Numerical Simulation on Solidification and Thermal Stress of Continuous Casting Billet in Mold Based 显示文摘 | Zhang L Shen H F Rong Y M | 2007 | Meshless Method Science and Engineering2007，，466： | 1 |
| 16 | Identification of isoflavonesin the roots of pueraria lobata显示文摘 | Rong Haojing Stevens J F Deinzeretal M L | 1998 | Planta Medica1998，64，： | 1 |
| 17 | Postischemic acute renal failure is reduced by short-term statin treatment in a rat model显示文摘 | Gueler F Rong S Park JK | 2002 | J Am Soc Nephrol2002，13，9： | 1 |
| 18 | Electrochemical NOx sensors based on interfacing nanosized LaFeO3 perovskite-type oxide and ionic conductors显示文摘 | Rong Y M Gu F C Wang J Z | 1995 | Transactions of Tianjin University1995，1，1： | 1 |
| 19 | PIK3CA mutations in breast cancer are associated with poor outcome显示文摘 | Li S Y Rong M Grieu F | 2006 | Breast Cancer Res Treat2006，96，1： | 1 |
| 20 | The importance of live biofilms in corrosion protection 显示文摘 | ZUO Rong jun KUS E MANSFELD F | 2005 | Corrosion Science2005，47，2： | 1 |
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