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| 1 | Bevacizumab for the management of diabetic macular edema显示文摘Diabetic retinopathy (DR) is a leading cause of vision loss in the working-age population and is relatedto 1%-5% of cases of blindness worldwide. Diabetic macular edema (DME) is the most frequent cause of DR vision loss and is an important public health problem. Recent studies have implicated vascular endothelial growth factor (VEGF) in DR and DME pathogenesis, as well as provided evidence of the benefits of anti-VEGF agents for the management of such conditions. Despite the benefits of intravitreal ranibizumab injection for the management of DME, the cost-effectiveness of intravitreal bevacizumab therapy has gained increasing interest in the scientific community. This review summarizes the studies examining bevacizumab for the management of DME, focusing on the efficacy and duration of the clinical benefits of decreasing DME and the improvement of best-corrected visual acuity (BCVA). There is strong evidence that intravitreal bevacizumab injection therapy has a good cost-effective profile in the management of DME and may be associated with laser photocoagulation; however, its clinical superiority in terms of the duration of DME regression and the improvement of BCVA compared with intravitreal ranibizumab and other intravitreal anti-VEGF therapies remains unclear and deserves further investigation. | Francisco Rosa Stefanini J Fernando Arevalo Maurício Maia | 2013 | World Journal of Diabetes2013，4，2： | 18 |
| 2 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 3 | Feeder-free maintenance of hESCs in mesenchymal stem cell-conditioned media: distinct requirements for TGF-β and IGF-Ⅱ显示文摘 | Rosa Montes Gertrudis Ligero Laura Sanchez Purificacidn Catalina Teresa de la Cueva Ana Nieto Gustavo J Melen Ruth Rubio Javier Garcia-Castro Clara Bueno Pablo Menendez | 2009 | Cell Research2009，19，6： | 7 |
| 4 | A human ESC model for MLL-AF4 leukemic fusion gene reveals an impaired early hematopoietic-endothelial specification显示文摘MLL-AF4 熔化基因是在在婴儿的高风险的尖锐成淋巴细胞的白血病的一个特点 genomic 错误。尽管 MLL-AF4 在人的开发期间出生前地产生,这很好被建立,它在在 utero 的造血的开发的效果仍然保持未经勘探。我们创造了一个人特定的细胞的系统在 MLL-AF4-expressing 人的胚胎的干细胞(hESCs ) 学习早 hemato-endothelial 开发。介绍的功能的研究,同种细胞的分析和基因表示表明在 hESCs 的 MLL-AF4 的那表情有 phenotypic,功能并且基因表示影响。MLL-AF4 在 hESCs 充当全球 transcriptional 使活跃之物和 homeobox 基因表示的一个积极管理者。机能上地, MLL-AF4 从 hESCs 提高 hemogenic 先锋的说明,但是强烈损害进一步造血的承诺赞成 endothelial 房间命运。MLL-AF4 hESCs transcriptionally 被告知向对 endothelial 成熟敏感的 hemogenic 先锋区分,由联系到 vascular-endothelial 功能和早造血作用的主人基因的显著 upregulation 思考了。而且,我们报导那 MLL-AF4 表情不是足够的转变导出 hESC 的造血的房间。这个工作说明 hESCs 怎么可以提供唯一的卓见进人的开发并且推进我们理解白血病的熔化基因,知道出生前地产生,调整人的胚胎的造血的说明。 | Clara Bueno Rosa Montes Gustavo J Melen Verdnica Ramos-Mejia Pedro J Real Ver6nica Ayllo'n Laura Sanchez Gertmdis Ligero Inmaculada Gutierrez-Aranda Agustin F Femfindez Mario F Fraga Inmaculada Moreno-Gimeno Deborah Btlrks Maria del Carmen Plaza-Calonge Juan C Rodriguez-Manzaneque Pablo Menendez | 2012 | Cell Research2012，22，6： | 2 |
| 5 | The changing paradigm for the treatment of colonic hemorrhage: superselective angiographic embolization显示文摘 | DeBarros J Rosas L Cohen J | 2002 | Dis Colon Rectum2002，45，6： | 1 |
| 6 | Pleiotropic effects of lactate dehydrogenase inactivationin Lactobacillus casei显示文摘 | María J José L G Vicente M Gaspar P | 2005 | Research in Microbiology2005，156，： | 1 |
| 7 | Primary Sjogren syndrome in Spain:clinical and immunologic expression in 1010 patients显示文摘 | Ramos-Casals M Solans R Rosas J | 2008 | Medicine2008，87，4： | 1 |
| 8 | Primary Sjtigren syndrome: clinical and immunologic disease patterns in a cohort of 400 patients显示文摘 | Garcia-Carrasco M Ramos-Casals M Rosas J | 2002 | Medicine (Baltimore)2002，81，： | 1 |
| 9 | Funding systems for higher education and their impacts on institutional strategies and academia:A comparative perspective显示文摘 | Frlich N Schmidt E K Rosa M J | 2010 | International Journal of Educational Management2010，24，1： | 1 |
| 10 | Primary Sjogrenr ssyndrome in Spain: clinical and immunologic expression in 1010patients显示文摘 | Ramos-Casals M Solans R Rosas J | 2008 | Medicine CBaltimore)2008，87，4： | 1 |
| 11 | Complication of the smooth pin fixation of fracture and dislocation in the handand wrist显示文摘 | Botte M J Davis JL Rosa BA | 1992 | Clin Orthop1992，，276： | 1 |
| 12 | Graftversus-host disease,an eight case report and literature review 显示文摘 | de la Rosa Garcia E Bologna Molina R Vega Gonzflez Tde J | 2006 | Med Oral Patol Oral Cir Bucal2006，11，6： | 1 |
| 13 | Severe CD4 T cell-mediated immunopathology in murine schistosomiasis is de- pendent on IL-12p40 and correlates with high levels of IL-17 显示文摘 | Rutitzky L I Lopes da Rosa J R Stadecker M J | 2005 | J Immunol2005，175，6： | 1 |
| 14 | New trends in dentine/enamel adhesion显示文摘 | Perdigao J Frankenberger R Rosa BT | 2000 | Am J Dent2000，13，： | 1 |
| 15 | Primary Sj(o)gren's syndrome:clinical and immunologic disease patterns in acohort of 400 patients显示文摘 | Garcia-Carrasco M Ramos-Casals M Rosas J | 2002 | Medicine (Baltimore)2002，81，： | 1 |
| 16 | Identification and quantitation of allelochemicals from the Lichen lethariella canariensis: phytotoxicity and antioxidative activity显示文摘 | TOLEDO M F J CASTELLANO A G ROSAS F E | 2003 | J Chem Ecol2003，29，9： | 1 |
| 17 | Assessing PAC contribution to the NOM fouling control in PAC/UF systems 显示文摘 | CAMPINAS M ROSA M J | 2010 | Water Research2010，44，： | 1 |
| 18 | Green clay and aloe vera peel-off facial masks:response surface methodology applied to the formulation design显示文摘 | Beringhs A O Rosa J M Stulzer H K | 2013 | American Association of Pharmaccu- tical Scientists2013，14，1： | 1 |
| 19 | Mood disorder as a manifestation of primary hy- poparathyroidism:A case report显示文摘 | Regis G Rosa Alcina J S Barros Antonio RB de Lima | 2014 | Journal of Medical Case Reports2014，8，4： | 1 |
| 20 | Development and vali- dation of a method for active drug identification and content deter- mination of ranitidine in pharmaceutical products using near-infra- red reflectance spectroscopy : a parametric release approach 显示文摘 | Rosa S S Barata P A Martins J M | 2008 | Talanta2008，75，： | 1 |
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