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89篇 您的检索式:作者名="RUGGERI B"
    题名 作者 年代 出处 被引量
1Nanoplasmonic mid-infrared biosensor for in vitro protein secondary structure detection显示文摘Plasmonic nanoantennas offer new applications in mid-infrared(mid-IR)absorption spectroscopy with ultrasensitive detection of structural signatures of biomolecules,such as proteins,due to their strong resonant near-fields.The amide I fingerprint of a protein contains conformational information that is greatly important for understanding its function in health and disease.Here,we introduce a non-invasive,label-free mid-IR nanoantenna-array sensor for secondary structure identification of nanometer-thin protein layers in aqueous solution by resolving the content of plasmonically enhanced amide I signatures.We successfully detect random coil to crossβ-sheet conformational changes associated withα-synuclein protein aggregation,a detrimental process in many neurodegenerative disorders.Notably,our experimental results demonstrate high conformational sensitivity by differentiating subtle secondary-structural variations in a nativeβ-sheet protein monolayer from those of crossβ-sheets,which are characteristic of pathological aggregates.Our nanoplasmonic biosensor is a highly promising and versatile tool for in vitro structural analysis of thin protein layers.Dordaneh Etezadi John B Warner IV Francesco S Ruggeri Giovanni Dietler Hilal A Lashuel Hatice Altug 2017Light(Science & Applications)2017,6,1:2
2Development of vascularendothelial growth factor receptor (VEGFR) kinase inhibitors asantiangiogenic agents in cancer therapy显示文摘Underiner TL Ruggeri B Gingrich DE 2004Curr Med Chem2004,11,6:1
3Initiation of platelet adhesion by arrest onto fibrinogen or translocation on von ebrand factor显示文摘Savage B Saldivar E Ruggeri ZM 1996Cell1996,84,2:1
4Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tu- morigenicity by antisense RNA显示文摘Cheng JQ Ruggeri B Klein WM 1996Proc Natl Acad Sci USA1996,93,8:1
5Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA 显示文摘Cheng JQ Ruggeri B Klein WM 1996Proc Natl Acad Sci USA1996,93,8:1
6Aprepitant versus dexam-ethasone for preventing chemotherapy-induced delayed emesis inpatients with breast cancer : a randomized double-blind study 显示文摘Roila F Ruggeri B Ballatori E 2014J Clin Oncol2014,32,2:1
7Alterations of the p53 tumor suppressor gene during mouse skin tumor progression显示文摘Ruggeri B Caamano J Goodrow J 1991Cancer Res1991,51,24:1
8Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tu- mofigenicity by antisense RNA 显示文摘Cheng JQ Ruggeri B Klein WM 1996Proc Natl Acad Sci USA1996,93,8:1
9Distinct biological consequences of integrin alpha v beta 3-mediated melanoma cell adhesion to fibrinogen and its plasmie fragments显示文摘Felding-Habermann B Ruggeri ZM Cheresh DA 1992J Biol Chem1992,267,8:1
10The impact of chemotherapy - induced nausea and vomiting on health - re- lated quality of life显示文摘Ballatori E Roila F Ruggeri B 2007Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer2007,15,2:1
11The impact ofchemotherapy - in- duced nausea and vomiting on health related quality of life 显示文摘Ballatori E Roila F Ruggeri B 2007Supportive Care in Cancer2007,15,2:1
12CEP-7055:a novally active pan inhibitor of vascular endothelial growth factor receptor tyrosine kinases with potent antiangiogenic activity and antitumor efficacy in preclinical modes显示文摘Ruggeri B singh J Gingrich D 2003Cancer Res2003,63,:1
13Vaginal replacement in the pediatric age group:a 34-year experience of intestinal vaginoplasty in children and young girls显示文摘LIMA M RUGGERI G RANDI B 2010J Pediatr Surg2010,45,10:1
14The impact of chemotherapyinduced nausea and vomiting on health-related quality of life显示文摘Ballatori E Roila F Ruggeri B 2007Support Care Cancer2007,15,:1
15Development of vascular endothelial growth factor receptor (VEGFR) kinase inhibitors as anti2 angiogenic agents in cancer therapy 显示文摘Underiner TL Ruggeri B Gingrich DE 2004Curr Med Chem2004,11,:1
16Rotavirus genotypes co-circulating in Europe between 2006 and 2009 as determined by EuroRotaNet, a pan- European collaborative strain surveillance network显示文摘Iturriza-Gomara M Dallman T Banyai K Bottiger B Buesa J Diedrich S Fiore L Johansen K Koopmans M Korsun N Koukou D Kroneman A Laszlo B Lappa- lainen M Maunula L Marques A M Matthijnssens J Midgley S Mladenova Z Nawaz S Poljsak-Prijatelj M Pothier P Ruggeri F M Sanchez-Fauquier A Steyer A Sidaraviciute-Ivaskeviciene I Syriopoulou V Tran A N Usonis V VAN Ranst M DE Rougemont A Gray J 2011Epidemiol Infect2011,139,6:1
17Rotavirus surveillance in Europe, 2005-2008: web-enabled repor- ting and real-time analysis of genotyping and epidemio- logical data显示文摘Iturriza-Gomara M Dallman T Banyai K Bottiger B Buesa J Diedrich S Fiore L Johansen K Korsun N Kroneman A Lappalainen M Laszlo B Maunula L Mat thinjnssens J Midgley S Mladenova Z Poljsak-Prijatelj M Pothier P Ruggeri F M Sanchez-Fauquier A Schreier E Steyer A Sidaraviciute I Tran A N Usonis V Van Ranst M de Rougemont A Gray J 2009J Infect Dis2009,2001,:1
18Cholecystokinin A and B receptors are differentially expressed in normal pancreas and pancreatic adenocarcinoma显示文摘Weinberg DS Ruggeri B Barber MT 1997J Clin Invest1997,100,3:1
19Immunohistochemical analysis of p53 expressionin human pancreatic carcinomas显示文摘Zhang SY Ruggeri B Agarwal P 1994Arch Patho Lab Med1994,118,2:1
20The impact of chemother- apy-induced nausea and vomiting on health--related quality of life显示文摘Ballatori E Roila F Ruggeri B 2007Supportive Care in Cancer2007,15,2:1
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