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| 1 | Monomethyl fumarate augments NK cell lysis of tumor cells through degranulation and the upregulation of NKp46 and CDIO7a显示文摘Dimethyl fumarate (DMF ) 是使用到对待的新药多重硬化(MS ) 病人。这里,我们在生来的杀手(NK ) 的各种各样的活动检验了 DMF 和 DMF 代谢物 monomethyl fumarate (MMF ) 的效果房间。我们证明 MMF 扩充 K562 和 RAJI 肿瘤房间的主要 CD56 +, 然而并非 CD56 −, NK 房间细胞溶解。MMF 为 24 h 在孵化以后在 CD56 +, 然而并非 CD56 −, NK 房间的表面上导致了 NKp46 表示。这效果密切通过这代谢物从这些房间在 CD56 + NK 房间和 Granzyme B 版本的正式就职的表面上与 CD107a 表示的 upregulation 被相关。anti-NKp46 抗体通过 CD56 + NK 房间禁止了 CD107a 的导致 MMF 的 upregulation 和肿瘤房间的细胞溶解。因此,这些结果是第一证明 MMF 扩充肿瘤目标房间的 CD56 + NK 房间细胞溶解,效果通过 NKp46 调停了。这新奇效果在癌症为治疗学或预防的协议建议 MMF 的使用。 | Heidi Vego Kristin L Sand Rune A Hoglund Lars-Egil Fallang Glenn Gundersen Trygve Holmoy Azzam A Maghazachi | 2016 | Cellular & Molecular Immunology2016，13，1： | 2 |
| 2 | Influence of different second generation antipsychotics on the QTc interval: A pragmatic study显示文摘AIM To investigate whether differential influence on the QTc interval exists among four second generation antipsychotics(SGAs) in psychosis.METHODS Data were drawn from a pragmatic, randomized headto-head trial of the SGAs risperidone, olanzapine, quetiapine, and ziprasidone in acute admissions patients with psychosis, and with follow-up visits at discharge or maximally 6-9 wk, 3, 6, 12 and 24 mo. Electrocardiograms were recorded on all visits. To mimic clinical shared decision-making, the patients were randomized not to a single drug, but to a sequenceof the SGAs under investigation. The first drug in the sequence defined the randomization group, but the patient and/or clinician could choose an SGA later in the sequence if prior negative experiences with the first one(s) in the sequence had occurred. The study focuses on the time of, and actual use of the SGAs under investigation, that is until treatment discontinuation or change, in order to capture the direct medication effects on the QTc interval. Secondary intention-to-treat(ITT) analyses were also performed. RESULTS A total of 173 patients, with even distribution among the treatment groups, underwent ECG assessments. About 70% were males and 43% had never used antipsychotic drugs before the study. The mean antipsychotic doses in milligrams per day with standard deviations(SD) were 3.4(1.2) for risperidone, 13.9(4.6) for olanzapine, 325.9(185.8) for quetiapine, and 97.2(42.8) for ziprasidone treated groups. The time until discontinuation of the antipsychotic drug used did not differ in a statistically significant way among the groups(Log-Rank test: P = 0.171). The maximum QTc interval recorded during follow-up was 462 ms. Based on linear mixed effects analyses, the QTc interval change per day with standard error was-0.0030(0.0280) for risperidone;-0.0099(0.0108) for olanzapine;-0.0027(0.0170) for quetiapine, and-0.0081(0.0229) for ziprasidone. There were no statistically significant differences among the groups in this regard. LME analyses based on ITT groups(the randomization groups), revealed almost identical slopes with-0.0063(0.0160) for risperidone,-0.0130(0.0126) for olanzapine,-0.0034(0.0168) for quetiapine, and-0.0045(0.0225) for ziprasidone. CONCLUSION None of the SGAs under investigation led to statistically significant QTc prolongation. No statistically significant differences among the SGAs were found. | Roy E Olsen Rune A Kroken Sigmund Bj?rhovde Kristina Aanesen Hugo A J?rgensen Else-Marie L?berg Erik Johnsen | 2016 | World Journal of Psychiatry2016，6，4： | 2 |
| 3 | Long-tern effect of rapid maxillary expansion studied in one patient with the aid of met allic implants and roentgen stereometry显示文摘 | Samas KV Bjork A Rune B | 1992 | Eur J Orthod1992，14，： | 1 |
| 4 | Vitamin D receptor: a new risk marker for clinical restenosis after percutaneous coronary intervention显示文摘 | Pascalle S Monraats Yue Fang Douwe Pons Nuno MM Pires Huibert AP Pols Aeilko H Zwinderman Moniek PM de Maat Pieter AF Doevendans Robbert J deWinter René A Tio Johannes Waltenberger Rune R Frants Paul HA Quax Arnoud van der Laarse Ernst E van der Wall Andr | 2010 | Expert Opinion on Therapeutic Targets2010，，： | 1 |
| 5 | Premissive hypercapnia during mechanical ventilation of neonates 显示文摘 | Rune T Namasivayam A | 2004 | Indian Pediatrics2004，41，： | 1 |
| 6 | Treatment of atrazine in nursery irrigation runoff by a constructed wetland显示文摘 | Runes H B Jenkins J J Moore J A | 2003 | Water Res2003，37，3： | 1 |
| 7 | Cerebral vasospasm evaluated by transcranial ultrasound correlated with clinical grade and CT visualized subarachnoid hemorrhage显示文摘 | Seiler RW Peter G Rune A | 1986 | J Neurosurg1986，64，： | 1 |
| 8 | Permissive hypercapnia during mechanical ventilation显示文摘 | Nanasivayam A | 2004 | Indian Pediatrics2004，41，3： | 1 |
| 9 | Premissive hypercapnia during mechanical ventilation of neonates 显示文摘 | Rune T Namasivayam A | 2004 | Indian Pediatr2004，41，： | 1 |
| 10 | Modal identification ofoutput-only systems using frequency domain 显示文摘 | Rune B ZHANG Lingmi Palle A | 2001 | SmartMaterials and Structures2001，10，： | 1 |
| 11 | Long-term effect of rapid maxillary expansion studied in one patient with the aid of metallic implants and roentgen stereometry显示文摘 | Samas KV Bjork A Rune B | 1992 | Eur J Orthod1992，14，6： | 1 |
| 12 | Strong in vivo activation of NF-κB in mouse lenses by classic stressors显示文摘 | George A Harald C Rune B | 2003 | Investigative Oph- Thalmology and Visual Science2003，44，6： | 1 |
| 13 | Takeover timing, implementation uncertainty, and embedded divestment options显示文摘 | Luis A Rune S | 2006 | Review of Finance2006，10，3： | 1 |
| 14 | A continental phenology model for monitoring vegetation responses to interannual climatic variability显示文摘 | White M A Thornton P E Runing S W | 1997 | Global Biogeochemical Cycles1997，11，2： | 1 |
| 15 | Treatment of atrazine in nursery irrigation runoff by a constructed wetland 显示文摘 | Runes H B Jemkins J J Moore J A | 2003 | Water Research2003，37，3： | 1 |
| 16 | A comparison of nonradioisotopic hybridization assay using fluores-cent,chemilu minescent and enzyme-labeled synthetic oligodeoxyribonucleotide pmbes显示文摘 | URDEA M S WARNER B D RUNING J A | 1988 | Nucleic Acids Res1988，16，： | 1 |
| 17 | siRNA-mediated reduction of inhibitor of nuclear factor-kappaB kinase prevents tumor necrosis factor-alpha-induced insulin resistance in human skeletal muscle 显示文摘 | Austin RL Rune A Bouzakri K | 2008 | Diabetes2008，57，： | 1 |
| 18 | Treatment of atrazine in nursery irrigation runoff by a constructed wetland显示文摘 | Runes H B Jenkins J J Moore J A | 2003 | Water Research2003，37，3： | 1 |
| 19 | Expres- sion and functional activity of chemokine receptors in glatiramer acetate-specific T cells isolated from multiple sclerosis patient receiving the drug glatiramer acetate显示文摘 | Rune A Huglund AL Hestvik T | 2011 | Human immunology2011，72，2： | 1 |
| 20 | Epri- nomectin pour-on for control of Boophilus microplus (Canestrini) ticks (Acar,: Ixo~dae) on cattle 显示文摘 | A~ D H Gaido A B Cat'rune M M | 2005 | Veterinary Parasitology2005，127，2： | 1 |
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