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| 1 | Radioembolization for the treatment of unresectable hepatocellular carcinoma:A clinical review显示文摘Hepatocellular carcinoma(HCC)is the sixth most common cancer in the world.The majority of patients with HCC present with unresectable disease.These patients have historically had limited treatment options secondary to HCC demonstrating chemoresistance to the currently available systemic therapies.Additionally, normal liver parenchyma has shown intolerance to tumoricidal radiation doses,limiting the use of external beam radiation.Because of these limitations,novel percutaneous liver-directed therapies have emerged. The targeted infusion of radioactive microspheres (radioembolization)represents one such therapy. Radioembolization is a minimally invasive transcatheter therapy through which radioactive microspheres are infused into the hepatic arteries that supply tumor. Once infused,these microspheres traverse the hepatic vascular plexus and selectively implant within the tumor arterioles.Embedded within the arterioles, the 90Y impregnated microspheres emit high energy and low penetrating radiation doses selectively to the tumor.Radioembolization has recently shown promise for the treatment of patients with unresectable HCC. The objective of this review article is to highlight twocurrently available radioembolic devices(90Y,188Rh)and provide the reader with a recent review of the literature. | Saad M Ibrahim Robert J Lewandowski Kent T Sato Vanessa L Gates Laura Kulik Mary F Mulcahy Robert K Ryu Reed A Omary Riad Salem | 2008 | World Journal of Gastroenterology2008，14，11： | 14 |
| 2 | Diffusion-weighted magnetic resonance imaging to predict response of hepatocellular carcinoma to chemoembolization显示文摘AIM: To investigate whether intra-procedural diffusion- weighted magnetic resonance imaging can predict response of hepatocellular carcinoma (HCC) during trans- catheter arterial chemoembolization (TACE). METHODS: Sixteen patients (15 male), aged 59 ±11 years (range: 42-81 years) underwent a total of 21 separate treatments for unresectable HCC in a hybrid magnetic resonance/interventional radiology suite. Ana- tomical imaging and diffusion-weighted imaging (b = 0, 500 s/mm2) were performed on a 1.5-T unit. Tumor enhancement and apparent diffusion coefficient (ADC, mm2/s) values were assessed immediately before and at 1 and 3 mo after TACE. We calculated the percent change (PC) in ADC values at all time points. We compared follow-up ADC values to baseline values using a paired t test (α = 0.05). RESULTS: The intra-procedural sensitivity, specificity, and positive and negative predictive values (%) for detecting a complete or partial 1-mo tumor response using ADC PC thresholds of ±5%, ±10%, and ±15% were 77, 67, 91, and 40; 54, 67, 88, and 25; and 46, 100, 100, and 30, respectively. There was no clear predictive value for the 3-mo follow-up. Compared to baseline, the immediate post-procedure and 1-mo mean ADC values both increased; the latter obtaining statistical significance (1.48 ± 0.29 mm2/s vs 1.65 ± 0.35 × 10-3 mm2/s, P < 0.014). CONCLUSION: Intra-procedural ADC changes of > 15% predicted 1-mo anatomical HCC response with the greatest accuracy, and can provide valuable feedback at the time of TACE. | Johnathan C Chung Neel K Naik Robert J Lewandowski Mary F Mulcahy Laura M Kulik Kent T Sato Robert K Ryu Riad Salem Andrew C Larson Reed A Omary | 2010 | World Journal of Gastroenterology2010，16，25： | 13 |
| 3 | Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial显示文摘 | David W Andrews Charles B Scott Paul W Sperduto Adam E Flanders Laurie E Gaspar Michael C Schell Maria Werner-Wasik William Demas Janice Ryu Jean-Paul Bahary Luis Souhami Marvin Rotman Minesh P Mehta Walter J Curran | 2004 | The Lancet . 2004 (9422)2004，，9422： | 2 |
| 4 | Fingerprint-based remote user authentication scheme using smart cards显示文摘 | LEE J K RYU S R YOO K Y | | 0，，12： | 2 |
| 5 | Damage identification in beam-type structures: frequency-based method vs mode-shape-based method 显示文摘 | Kim J T Ryu Y S Cho H M | 2003 | Engineering Structures2003，25，1： | 2 |
| 6 | Error analysis of a flexure hinge mecha nism induced by machining imperfection显示文摘 | Ryu J W Gweon D G | 1997 | Precision Engineering1997，21，23： | 2 |
| 7 | Failure analysis and retrofit design of low pressure 1st stage blades for a steam turbine显示文摘 | XU Zili PARK J P RYU S J | 2007 | Engineering Failure Analysis2007，14，4： | 1 |
| 8 | Scdium-based dry regenerable sorbent for carbon dioxide capture from power plant flue gas显示文摘 | Lee J B Ryu C K Baek J | 2008 | Ind Eng Chem Res2008，47，13： | 1 |
| 9 | Radium tracing of submarine groundwater discharge (SGD) and associated nutrient fluxes in a highly-permeable bed coastal zone, Korea 显示文摘 | Kim G Ryu J W Hwang D W | 2008 | Marine Chemistry2008，，109： | 1 |
| 10 | The combined effects of anti - TNFα antibody and IL - 1 receptor antagonist in human rheumatoid arthritis synovial membrane 显示文摘 | Hosaka K Ryu J Saitoh S | 2005 | Cytokine2005，32，6： | 1 |
| 11 | Fabrication of homostructure ZnO p-n junctions显示文摘 | Kim W J White H M | 2000 | J Cryst Growth2000，219，： | 1 |
| 12 | Effect of modification with HNO3 and NaOH on metal adsorption by pitch-based active carbon fibers显示文摘 | Park S J Ryu S K | 2001 | Carbon2001，39，： | 1 |
| 13 | Random sequence analy-sis of genomie DNA of a hyperthemophile:Aquifex pyrophilus显示文摘 | Kim S S Ryu J R | 1997 | Extremophiles1997，1，3： | 1 |
| 14 | Correlation of microstructure with dynamic deformation behavior and penetration performance of tungsten heavy alloys fabricated by mechanical alloying显示文摘 | LEE S RYU H J | 2000 | Metall and Mater Trans A2000，31，： | 1 |
| 15 | Fine mapping of virus-neutralizing epitopes on hepatitis B virus PreS1显示文摘 | Maeng C Y Ryu C J Gpipon P | 2000 | Virology2000，270，1： | 1 |
| 16 | 显示文摘 | Ryu S Park J H Jang H M | 2007 | Appl Phys Lett2007，91，14： | 1 |
| 17 | Differential Immunostimulatory Effects of Gram - positive Bacteria Due to Their Lipoteichoic Acids 显示文摘 | Ryu Y H Balk J E Yang J S | 2009 | Int hmnunopharmacol2009，9，1： | 1 |
| 18 | Quantitative analysis of antioxidants in sesame seed 显示文摘 | RYU S R LEE J I KANG S S | 1992 | Korean J Crop Sci1992，37，4： | 1 |
| 19 | Further improvement of an efficient password based remote user authentication scheme asing smart cards显示文摘 | Yoon E J Ryu E K Yoo K Y | 2004 | IEEE Transactions on Consumer Electronics2004，50，2： | 1 |
| 20 | Electromagnetic fields about a loop source of current显示文摘 | Ryu J Morrison F H Ward S H | 1970 | Geophysics1970，35，： | 1 |
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