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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | The role of ultrasonography and automatic-needle biopsy in outpatient percutaneous liver biopsy显示文摘 | KD Lindor C Bru RA Jorgensen J Rakela JM Bordas JB Gross J Rodes DB McGill CC Reading EM James JW Charboneau J Ludwig KP Batts AR Zinsmeister | 1996 | Hepatology1996，，5： | 2 |
| 3 | Current methods of non - invasive ventilatory support for neonates 显示文摘 | Mahmoud RA Roehr CC Schmalisch G | 2011 | Paediatr Respir Rev2011，12，3： | 1 |
| 4 | Effects of local tram- adol administration on peripheral glutamate-induced nociceptive behaviour in mice显示文摘 | Wang JT Chung CC Whitehead RA | 2010 | Can J Anaesth2010，57，7： | 1 |
| 5 | Orchiectomy and nilutamide or placebo as treatment of metastatic prostatic cancer in a multinational double-blind randomized trial显示文摘 | Janknegt RA Abbou CC Bartoletti R | 1993 | Urol1993，149，： | 1 |
| 6 | British Society for Medical Mycology proposed standards of care for patients with invasive fungal infections显示文摘 | Dening DW Kibbler CC Barnes RA | 2003 | Lancet Infect Dis2003，3，4： | 1 |
| 7 | Incidence,survivaland risk factors for the development of veno-occlusive disease in pediatric hematopoietic stem cell transplant recipients显示文摘 | Barker CC Butzner JD Anderson RA | 2003 | Bone Marrow Transplant2003，，： | 1 |
| 8 | Bactericidal activity of amonocytic cell line(THP-I)against common respiratory tract bacterial pathogens is depressed after infection with respiratory syncytialvirusf显示文摘 | Raza MW Blackwell CC Ehon RA et a1 | 2000 | Med Microbiol2000，49，3： | 1 |
| 9 | Bactericidal activity of a monocytic cell line(THP-1)against common respiratory tract bacterial pathogens is depressed after infection with respiratory syncytial virus显示文摘 | Raza MW Blackwell CC Ehon RA | 2000 | J Med Microbiol2000，49，3： | 1 |
| 10 | Evidence that invasion-inhibitory antibodies specific for the 19-kDa fragment of merozoite surface protein-1 (MSP-1 19) can play a protective role against blood-stage Plasmodium falciparum infection in individuals in a malaria endemic area of Africa显示文摘 | John CC O'Donnell RA Sumba PO | 2004 | J Immunol2004，173，1： | 1 |
| 11 | Current methods of non-invasive ventilatory support for neonates显示文摘 | Mahmoud RA Roehr CC Schmalisch G | | 0，，03： | 1 |
| 12 | British Society for Medical Mycology proposed standards of care for patients with invasive fungal infections 显示文摘 | Denning DW Kibbler CC Barnes RA | 2003 | Lancet Infect Dis2003，3，： | 1 |
| 13 | Biochemical investigation of pikromycin biosynthesis employing native penta- and hexaketide chain elongation intermediates显示文摘 | Aldrich CC Beck BJ Fecik RA | 2005 | J Am Chem Soc2005，127，23： | 1 |
| 14 | Penile metastasis secondary to supraglottic squamous cell carcinoma : review of tne literature显示文摘 | Perez LM Shumway RA Carson CC | 1992 | J Urol1992，147，： | 1 |
| 15 | Incidence, survival and risk factors for the development of veno-occlusive disease in pediatric hematopoietic stem cell transplant recipients 显示文摘 | Barker CC Butzner JD Anderson RA | 2003 | Bone Marrow Transplant2003，32，1： | 1 |
| 16 | Orchiectomy and nilutamide or placebo as treatment of metastatic prostatic cancer in a multinational double blind randomized trial显示文摘 | Janknegt RA Abbou CC Bartoletti R | 1993 | J Urol1993，149，1： | 1 |
| 17 | Apolipoprotein in hyperlipidemia显示文摘 | Hegele RA | 1994 | Ann intern Med1994，120，： | 1 |
| 18 | Decreasing sedentary behaviors in treating pediatric obesity 显示文摘 | Epstein LH Paluch RA Gordy CC Dorn J | 2000 | Arch Pediatr Adolese Med2000，154，： | 1 |
| 19 | Technological ad-vances in radiotherapy for the treatment of localised prostatecancer显示文摘 | Mangar SA Huddart RA Parker CC | 2005 | Eur J Cancer2005，41，： | 1 |
| 20 | Over 18 h to posi- tivity in the BacT/ALERT system with clustered Gram - positive coc- ci is highly predictive of coagulase - negative staphylococci 显示文摘 | Zimennan RA Machado DP Constante CC | 2007 | J Clin Pathol2007，60，6： | 1 |
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