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| 1 | Etiology of fulminant hepatic failure:experience from a tertiary hospital in Bangladesh显示文摘BACKGROUND: Fulminant hepatic failure (FHF) is not uncommon in our clinical practice in Bangladesh. There was a rise in acute hepatitis E virus (HEV) in Bangladesh after the 2004 floods. At that time, most of the country was under water for more than a month, leading to sewage contamination of the water supply. The aim of this study was to investigate the etiology of FHF in Bangladesh. METHODS: In this retrospective study, 23 patients with FHF who presented with severe impairment of hepato- cellular function (i.e. encephalopathy, coagulopathy and jaundice) within 6 months of onset of symptoms were included. There were 17 men and 6 women, aged from 18 to 32 years. Four of the women were pregnant. Patients were tested for markers for common hepatotrophic viruses. A relevant history was taken and the Patient Record Book of the Unit was reviewed. RESULTS: 56.52% patients (13/23) had HEV infection, and all were anti-HEV IgM-positive tested by ELISA. HBV infection was detected in 34.78% patients (8/23), all of whom were tested positive for either HBsAg or anti-HBs IgM by ELISA. 8.7% patients (2/23) had a positive history for intake of alcohol and/or drugs. CONCLUSIONS: Acute HEV infection is the leading cause of FHF in Bangladesh. Sewage contamination of the water supply following floods contributes to a higher incidence of HEV infection. HBV infection is also important. | Mamun-Al Mahtab Salimur Rahman Mobin Khan Ayub Al Mamun Shahrin Afroz | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，2： | 5 |
| 2 | Drainage vs. non-drainage after cholecystectomy for acute cholecystitis:a retrospective study显示文摘Many surgeons practice prophylactic drainage after cholecystectomy without reliable evidence,this study was conducted to answer the question whether to drain or not to drain after cholecystectomy for acute calculous cholecystitis.A retrospective review of all patients who had cholecystectomy for acute cholecystitis in Aseer Central Hospital,Abha,Saudi Arabia,was conducted from April 2010 to April 2012.Data were extracted from hospital case files.Preoperative data included clinical presentation,routine investigations and liver function tests.Operative data included excessive adhesions,bleeding,bile leak,and drain insertion.Complicated cases such as pericholecystic collections,mucocele and empyema were also reported.Patients who needed therapeutic drainage were excluded.Postoperative data included hospital stay,volume of drained fluid,time of drain removal,and drain site problems.The study included 103 patients allocated into two groups;group A(n = 38) for patients with operative drain insertion and group B(n = 65) for patients without drain insertion.The number of patients with preoperative diagnosis of acute non-complicated cholecystitis was significantly greater in group B(80%) than group A(36.8%)(P < 0.001).Operative time was significantly longer in group A.All patients who were converted from laparoscopic to open cholecystectomy were in group A.Multivariate analysis revealed that hospital stay was significantly(P < 0.001) longer in patients with preoperative complications.There was no added benefit for prophylactic drain insertion after cholecystectomy for acute calculous cholecystitis in non-complicated or in complicated cases. | Mohammed A Bawahab Walid M Abd El Maksoud Saeed A Alsareii Fahad S Al Amri Hala F Ali Abdul Rahman Nimeri Abdul Rahman M Al Amri Adel A Assiri Mohammed I Abdul Aziz | 2014 | The Journal of Biomedical Research2014，28，3： | 3 |
| 3 | Thrombin-induced p65 homodimer binding to downstream NF-kappa B site of the promoter mediates endothelial ICAM-1 expression and neutrophil adhesion显示文摘 | Rahman A Anwar KN True AL Malik AB | 1999 | J Immunol1999，162，： | 1 |
| 4 | Simula- tion of chloride migration in compression - induced damage inconcrete显示文摘 | RAHMAN MK AL - KUTTI WA SHAZALI M | 2012 | J Mater Civil Eng2012，24，7： | 1 |
| 5 | Multiple repeat cesareansections : operative difficulties, maternal complications and outcome显示文摘 | Gasim T Al Jama FE Rahman MS | 2013 | JReprod Med2013，58，78： | 1 |
| 6 | Multiple repeat cesarean sections:operative difficulties, maternal complications and outcome 显示文摘 | Gasim T Al Jama FE Rahman MS | 2013 | J Reprod Med2013，58，78： | 1 |
| 7 | Activation of NF-kappa B induced by H(2)O(2) and TNF-alpha and its effects on ICAM-1 expression in endothelial cells显示文摘 | True AL Rahman A Malik AB | 2000 | Am J Physiol Lung Cell Mol Physiol2000，279，2： | 1 |
| 8 | Combined occur- rence of hyperthyroid craves' and Hashimoto's thyroiditis 显示文摘 | Sutradhar SR Siddiqui N1 Rahman $ e! al | 2006 | Mymensingh Med J2006，15，1： | 1 |
| 9 | Expression of nu clear Notch3 in cervical squamous cell carcinomas and its asso- ciation with adverse clinical outcomes 显示文摘 | Yeasmin S Nakayama K Rahman MT el al | 2010 | Gynecol Oncol2010，117，3： | 1 |
| 10 | Activation of NF-B induced by H2O2 and TNF- and its effects on ICAM-1 expression in endothelial cells显示文摘 | True AL Rahman A Malik AB | 2000 | Am J Physiol Lung Cell Mol Physiol2000，279，2： | 1 |
| 11 | Thrombin-induced P65 homodimer binding to downstream site of the promoter mediates endothelial ICAM-1 expression and netrophil adhesion显示文摘 | Rahman A Anwar KN True Al | 1999 | J Immunol1999，162，9： | 1 |
| 12 | Structural basis for the recognition between HIV-I integrase and trans- criptional coactivator p75 显示文摘 | Cherepanov P Ambrosio AL Rahman S et ol | 2005 | Proc Natl Acad Sci USA2005，102，17： | 1 |
| 13 | Low polydispersity novolak resins for i-line resists显示文摘 | Wanat S Dalil Rahman M et al | 1999 | SPIE Proceedings1999，，3678： | 1 |
| 14 | Thrombin-induced P65 homodimer binding to downstream NF-kappa B site of the promotor mediates endothelial ICAM-1 expression and neutrophil adhesion 显示文摘 | Rahman A Anwar KN True AL | 1999 | J Immunol1999，162，9： | 1 |
| 15 | Structural basis for the recognition between HIV-1 integrase and transcriptional coactivator p75 显示文摘 | Cherepanov P Ambrosio AL Rahman S | 2005 | Proc Natl Acad Sci USA2005，102，17： | 1 |
| 16 | Pediatric ependymoma: biological perspectives 显示文摘 | Kilday JP Rahman R Dyer S et al | 2009 | Mol Cancer Res2009，7，6： | 1 |
| 17 | Presentation, treatmenl and outcome in patienls with ampullary turnouts 显示文摘 | Bellschart V Rahman MQ Engelken FJ el al | 2004 | Br J Surg2004，91，12： | 1 |
| 18 | Viral load speaks little about toll on liver显示文摘BACKGROUND:Bangladesh is situated in the intermediate prevalence region of hepatitis B virus (HBV).The lifetime risk of acquiring HBV infection in Bangladesh is greater than 40%.It has been estimated that this virus is responsible for 10%-35%cases of acute viral hepatitis,35.7%cases of fulminant hepatic failure, 33.3%-40.5%cases of chronic hepatitis and 46.8%cases of hepatocellular carcinoma in Bangladesh.The aim of this study is to compare the correlation between HBV DNA load and grade and stage of liver disease in patients with chronic hepatitis B(CHB). METHODS:Percutaneous liver biopsies done in 159 CHB patients revealed 62.9%(100 patients)had wild type HBV infection and the rest 37.1%(59)had pre-core/core promoter mutant HBV infection.HBV DNA load was measured using PCR in all patients. RESULTS:In the wild type CHB group,97%(97 patients) had moderate to high HBV DNA load and 3%(3)had low to moderate HBV DNA.In the pre-core/core promoter mutant group,74.6%(44 patients)had moderate to high HBV DNA and the rest 25.4%(15)had low to moderate HBV DNA.The patients with moderate to high HBV DNA of the patients with wild type CHB,78.4%(76 patients) had minimal to mild chronic hepatitis(HAI-NI 0-8)and 21.6%(21)had moderate to severe chronic hepatitis(HAI- NI 9-18).66.6%(2 patients)and 33.3%(1)patients with low to moderate HBV DNA load had minimal to mild and moderate to severe chronic hepatitis respectively.In the moderate to high HBV DNA group,77.3%(75 patients) patients had minimal to moderate fibrosis(HAI-F 0-2)and 22.7%(22)(HAI-F 3-4)had severe fibrosis to cirrhosis.These figures were 33.3%(1 patient)and 66.6% (2)respectively in the patients with low to moderate HBV DNA load.On the other hand in case of patients with pre-core/core promoter mutant type CHB,in the moderate to high HBV DNA group,79.5%(35 patients)had minimal to mild chronic hepatitis(HAI-NI 0-8)and 20.5%(9)had moderate to severe chronic hepatitis(HAI-NI 9-18).93.3% (14)and 6.7%(1)patients with low to moderate HBV DNA load had minimal to mild and moderate to severe chronic hepatitis respectively.In the moderate to high HBV DNA group,68.2%(30 patients)had minimal to moderate fibrosis(HAI-F 0-2)and 31.8%(14)(HAI-F 3-4)had severe fibrosis to cirrhosis.These figures were 86.7%(13)and 13.3%(2)respectively in patients with low to moderate HBV DNA load. CONCLUSIONS:The study shows that high HBV DNA load does not correlate with necro-inflammatory activity or extent of fibrosis in the liver in patients with either wild type or pre-core mutant type CHB. | Mamun-Al Mahtab Salimur Rahman Mobin Khan Md Kamal Ayub Al Mamun Md Fazal Karim | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，5： | 1 |
| 19 | Galpha (q)and Gbetagamma regulate PAR-1 signaling of thrombin-induced NF-kappaB activation and ICAM-1 transcription in endothelial cells显示文摘 | RAHMAN A TRUE AL ANWAR KN | 2002 | Circ Res2002，91，2： | 1 |
| 20 | The dynamics of probiotics on growth performance and immune response in broilers显示文摘 | Kabir S M L Rahman M M Rahman M B er al | 2004 | International Journal of Poultry Science2004，3，5： | 1 |
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