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| 1 | Hand Foot and Mouth Disease Due to Enterovirus 71 in Malaysia显示文摘Hand foot and mouth disease is a febrile sickness complex characterized by cutaneous eruption (exanthem) on the palms and soles with simultaneous occurrence of muco-cutanous vesiculo-ulcerative lesions (enanthem) affecting the mouth. The illness is caused by a number of enteroviruses with coxsackievirus A16 and enterovirus 71 as the main causative agents. Human enterovirus 71 (EV71) belongs to the species Human enterovirus A under the genus Enterovirus within the family Picornaviridae. EV71 has been associated with an array of clinical diseases including hand foot and mouth disease (HFMD), aseptic meningitis, encephalitis and poliomyelitis-like acute flaccid paralysis. A large outbreak of HFMD due to highly neurovirulent EV71 emerged in Malaysia in 1997, and caused 41 deaths amongst young children. In late 2000, a recurrence of an outbreak of HFMD occurred in Malaysia with 8 fatalities in peninsular Malaysia. Outbreak of HFMD due to EV71 recurred in 2003 with an unknown number of cases and mortalities. A similar outbreak of HFMD with 2 recorded deaths in young children occurred in peninsular Malaysia in late 2005 and this was followed by a larger outbreak in Sarawak (Malaysian Borneo) with 6 reported fatalities in the early part of 2006. The current on-going outbreak of HFMD started in peninsular Malaysia in epidemiological week 12 of 2010. As with other HFMD outbreaks in Malaysia, both EV71 and CA16 were the main aetiological viruses isolated. In similarity with the HFMD outbreak in 2005, the isolation of CA16 preceded the appearance of EV71. Based on the VP1 gene nucleotide sequences, 4 sub-genogroups of EV71 (C1, C2, B3 and B4) co-circulated and caused the outbreak of hand, foot and mouth disease in peninsular Malaysia in 1997. Two sub-genogroups (C1 and B4) were noted to cause the outbreak in 2000 in both peninsular Malaysia and Sarawak. EV71 of sub-genogroup B5 with smaller contribution from sub-genogroup C1 caused the outbreak in 2003. In the 2005 outbreak, besides the EV71 strains of sub-genogroup C1, EV71 strains belonging to sub-genogroup B5 were isolated but formed a cluster which was distinct from the EV71 strains from the sub-genogroup B5 isolated in 2003. The four EV71 strains isolated from clinical specimens of patients with hand, foot and mouth disease in the Sarawak outbreak in early 2006 also belonged to sub-genogroup B5. Phylogenetic analysis of the VP1 gene suggests that the EV71 strains causing the outbreak in Sarawak could have originated from peninsular Malaysia. Epidemiological and molecular data since 1997 show the recurrence of HFMD due to EV71 in Malaysia every 2 to 4 years. In each of the past outbreaks, more than one sub-genogroup of the virus co-circulate. | Kaw Bing Chua Abdul Rasid Kasri | 2011 | Virologica Sinica2011，26，4： | 71 |
| 2 | Isolation and selection of reference genes for Ganoderma boninense gene expression study using quantitative Real-time PCR (qPCR) 显示文摘 | Lim F-H Fakhrana I N Rasid O A | 2014 | Journal of Oil Palm Research2014，26，2： | 1 |
| 3 | Nonalcoolic steatoepatitis in cildren显示文摘 | Roberts E A | 2002 | J Pediatr Gastroenterol Nutr2002，30，6： | 1 |
| 4 | Mechanical Propertiesand Dynamic Mechanical Analysis of Thermoplastic-Natural RubberReinforced Short Carbon Fiber and KenM Fiber Hybrid Composites 显示文摘 | Anuar H Ahmad S H Rasid R | 2008 | Journal of Applied Polymer Science2008，107，6： | 1 |
| 5 | Utilizing neighbours-table to improve tree routing 显示文摘 | Mostafa KA AI-Harbawi Mohd Fadlee A Rasid Nor Karnariah Noordin | 2012 | Wireless Personal Communications2012，65，： | 1 |
| 6 | The effects of two types of relaxation training on students' levels of anxiety显示文摘 | Zulkifli Mohamed Rasid Thomas S Parish | 1998 | Adolescence1998，33，1： | 1 |
| 7 | Floodplain Management in Thunder Bay显示文摘 | Rasid Harun | 1998 | Canadian Research1998，13，1： | 1 |
| 8 | Mechanical properties and dynamic mechanical analysis of thermoplasticnaturalrubberreinforced short carbon fiber and kenaf fiber hybrid composites显示文摘 | Anuar H Ahmad S H Rasid R | 2008 | Journal of Applied Polymer Science2008，107，6： | 1 |
| 9 | Bluetooth telemedicine pro- cessor for muhichannel biomedical signal transmission via mo- bile cellular networks 显示文摘 | RASID M F A WOODWARD B | 2005 | Information Technology in Biomedi- cine IEEE Transactions on2005，9，1： | 1 |
| 10 | High performance nonlinear MIMO field weakening controller of a separately excited dc motor显示文摘 | RASID | 2000 | Electric Power Systems Research2000，15，15： | 1 |
| 11 | Detection of denial of service attacks against domain name system using neural net- works显示文摘 | Rastegari S Saripan M I Rasid M F A | 2009 | IJCSI International Journal of Computer Science Issues2009，，1： | 1 |
| 12 | A detection of denial of service attacks against domain name system using neural net- works 显示文摘 | Rastegari S Saripan M I Rasid M F | 2009 | UCSI International Journal of Computer Science2009，15，1： | 1 |
| 13 | Cloud computing aw- areness and adoption among accounting practitioners in Malaysia 显示文摘 | Tarmidi M Rasid S Z A Alrazi B | 2014 | International Conference on Accounting Studies 2014 ICAS 20142014，164，31： | 1 |
| 14 | Utilizing neighbours-table to improve tree routing 显示文摘 | AL-HARBAWI M K A RASID M F A NOORDIN N K | 2012 | Wireless personal communications2012，65，2： | 1 |
| 15 | The effects of two types of relaxation training on students' levels of anxiety显示文摘 | Rasid ZM Parish TS | 1998 | Adolescence1998，33，129： | 1 |
| 16 | The effects of two types of relaxation training on students' levels of anxiety显示文摘 | Rasid ZM Parish TS | 1998 | Adolescence1998，33，129： | 1 |
| 17 | Bluetooth Telemedicine Processor for Multichannel Biomedical Signal Transmission via Mobile Cellular Networks显示文摘 | RASID MFA WOODWARS B | 2005 | IEEE Transactions on Information Technology in Biomedicine2005，9，1： | 1 |
| 18 | Outcome of ventricular septal defect closure 显示文摘 | Saleem K Ahmad SA Rasid A | 2004 | J Coll Physicians Surg Pak2004，14，6： | 1 |
| 19 | Bluetooth telemedicine processor for multichannel biomedical signal transmission via mobile cellular networks 显示文摘 | RASID M F A WOODWARD B | 2005 | IEEE Transactions on Information Technology in Biometlicine2005，9，1： | 1 |
| 20 | The effects of two types of relaxation training on students' levels of anxiety 显示文摘 | Rasid ZM Parish TS | 1998 | adolescence1998，33，129： | 1 |
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