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| 1 | Severe acute pancreatitis: Clinical course and management显示文摘Severe acute pancreatitis (SAP) develops in about 25% of patients with acute pancreatitis (AP). Severity of AP is linked to the presence of systemic organ dysfunctions and/or necrotizing pancreatitis pathomorphologically. Risk factors determining independently the outcome of SAP are early multi-organ failure, infection of necrosis and extended necrosis (> 50%). Up to one third of patients with necrotizing pancreatitis develop in the late course infection of necroses. Morbidity of SAP is biphasic, in the first week strongly related to early and persistence of organ or multi-organ dysfunction. Clinical sepsis caused by infected necrosis leading to multi-organ failure syndrome (MOFS) occurs in the later course after the first week. To predict sepsis, MOFS or deaths in the first 48-72 h, the highest predictive accuracy has been objectified for procalcitonin and IL-8; the Sepsis- Related Organ Failure Assessment (SOFA)-score predicts the outcome in the first 48 h, and provides a daily assessment of treatment response with a high positive predictive value. Contrast-enhanced CT provides the highest diagnostic accuracy for necrotizing pancreatitis when performed after the first week of disease. Patients who suffer early organ dysfunctions or at risk of developing a severe disease require early intensive care treatment. Early vigorous intravenous fluid replacement is of foremost importance. The goal is to decrease the hematocrit or restore normal cardiocirculatory functions. Antibiotic prophylaxis has not been shown as an effective preventive treatment. Early enteral feeding is based on a high level of evidence, resulting in a reduction of local and systemic infection. Patients suffering infected necrosis causing clinical sepsis, pancreatic abscess or surgical acute abdomen are candidates for early intervention. Hospital mortality of SAP after interventional or surgical debridement has decreased in high volume centers to below 20%. | Hans G Beger Bettina M Rau | 2007 | World Journal of Gastroenterology2007，13，38： | 122 |
| 2 | Correlation of IL-8 with induction, progression and metastatic potential of colorectal cancer显示文摘AIM: To investigate the expression profile of IL-8 in inflammatory and malignant colorectal diseases to evaluate its potential role in the regulation of colorectal cancer (CRC) and the development of colorectal liver metastases (CRLM). METHODS: IL-8 expression was assessed by quantitative real-time PCR (Q-RT-PCR) and the enzyme-linked immunosorbent assay (ELISA) in resected specimens from patients with ulcerative colitis (UC, n = 6) colorectal adenomas (CRA, n = 8), different stages of colorectal cancer (n = 48) as well as synchronous and metachronous CRLM along with their corresponding primary colorectal tumors (n = 16). RESULTS: IL-8 mRNA and protein expression was significantly up-regulated in all pathological colorectal entities investigated compared with the corresponding neighboring tissues. However, in the CRC specimens IL-8 revealed a significantly more pronounced overexpression in relation to the CRA and UC tissues with an average 30-fold IL-8 protein up-regulation in the CRC specimens in comparison to the CRA tissues. Moreover, IL-8 expression revealed a close correlation with tumor grading. Most interestingly, IL-8 up-regulation was most enhanced in synchronous and metachronous CRLM, if compared with the corresponding primary CRC tissues. Herein, an up to 80-fold IL-8 overexpression in individual metachronous metastases compared to normal tumor neighbor tissues was found. CONCLUSION: Our results strongly suggest an association between IL-8 expression, induction and progression of colorectal carcinoma and the development of colorectal liver metastases. | Claudia Rubie Vilma Oliveira Frick Sandra Pfeil Mathias Wagner Otto Kollmar Berit Kopp Stefan Grber Bettina M Rau Martin K Schilling | 2007 | World Journal of Gastroenterology2007，13，37： | 12 |
| 3 | Inflammatory mediators in human acute pancreatitis: Clinical and pathophysiological implications显示文摘 | Mager M Rau B | 2000 | Gut2000，47，4： | 2 |
| 4 | Therapeutic Application of Caspase 1/Interleukin-1β-Converting Enzyme Inhibitor Decreases the Death Rate in Severe Acute Experimental Pancreatitis显示文摘 | Adam S. Paszkowski Bettina Rau Jens M. Mayer Peter M?ller Hans G. Beger | 2002 | Annals of Surgery2002，，1： | 2 |
| 5 | 轿车变速器的表面致密化粉末冶金齿轮的使用性能显示文摘选择性表面致密化是改进粉末冶金钢的一种方法,高负载齿轮经过这种加工工艺处理,就能达到使用要求。本文介绍了粉末冶金螺旋齿轮的制造工艺与性能,用三轴总成成对试验台架、承载能力试验台架及噪声试验台架测定了齿轮的使用性能,并把试验结果和具有同样几何形状与表面质量的锻钢齿轮的数据进行了比较。结果表明,粉末冶金齿轮的承载能力与噪声级可和锻钢齿轮相媲美。 | Cünter Rau Lorenz S Sigl Gerold Mrk Frank Wattenberg 韩凤麟 | 2012 | 粉末冶金技术2012，30，4： | 2 |
| 6 | Characteristics of infection with Candida species in patients with necrotizing pancreatitis显示文摘 | Isenmann R Schwarz M Rau B | 2002 | World J Surg2002，26，： | 1 |
| 7 | Abdominal compartmentsyndrome: prevention and treatment 显示文摘 | Tons C Schacht rupp A Rau M | 2000 | Chirurg2000，71，8： | 1 |
| 8 | Characteristics of infection with Candida species in patients with necrotizing pancreatitis显示文摘 | Isenmann R Schwarz M Rau B | 2002 | World J Surg2002，26，3： | 1 |
| 9 | CC-chemokine activation in acute pancreatitis: enhanced release of monocyte chemoattractant protein-1 in patients with local and systemic complications 显示文摘 | RAU B BAUMGART K KRUGER C M | 2003 | Intensive Care Med2003，29，5： | 1 |
| 10 | Argatroban for elective percutaneous coronary intervention: the ARG-E04 multi-center study显示文摘 | R? ssig L Genth-Zotz S Rau M | 2011 | Int J Cardiol2011，148，2： | 1 |
| 11 | Hastening, delaying, or averting sudden death of quantum entanglement 显示文摘 | RAU A R P ALl M ALBER G | 2008 | Europhys Lett2008，，40： | 1 |
| 12 | Elevation of vascular endothelial growth factor-A serum levels following acute myocardial infarction,Evidence for its origin and functional significance显示文摘 | Kranz A Rau C Kochs M | 2000 | J Mol Cell Cardid2000，32，1： | 1 |
| 13 | Quantum discord for two-qubit X states显示文摘 | M Ali A R P Rau G Alber | 2010 | Phys Rev A2010，81，04： | 1 |
| 14 | A highly immunogenic and protective middle east respiratory syndrome coro- navirus vaccine based on a recombinant measles virus vaccine platform显示文摘 | Malczyk A H Kupke A Prufer S Scheuplein V A Hutzler S Kreuz D Beissert T Bauer S Hubich Rau S Tondera C Eldin H S Schmidt J Vergara-Alert J Suzer Y Seifried J Hanschmann K M Kalinke U Herold S Sahin U Cichutek K Waibler Z Eickmann M Becker S Muhlebach M D | 2015 | J Virol2015，89，11： | 1 |
| 15 | M-odulation of Pharmacokinetics of Radioiodinated Sugar-conjugated Somatostatin Analogues by Variation of Peptide Net Charge and Carbohydration Chemistry显示文摘 | SCHOTTELIUS M RAU F REUBI JC | 2005 | Bioconjug Chem2005，16，2： | 1 |
| 16 | Prescribed fire in a Great Basin Sagebrush Ecosystem: Dynamics of Soil Extract able Nitrogen and Phosphorus 显示文摘 | RAU B M BLANK R R CHAMBERS J C | 2007 | Journal of Arid Environments2007，71，4： | 1 |
| 17 | Nonsuicidal self-injury and its relation to personality traits in medical students显示文摘 | Allroggen M Kleinrahm R Rau TA | 2014 | Journal of Nervous and Mental Disease2014，202，4： | 1 |
| 18 | Influence of treat- ment modality on angiographic outcome after coronary stenting in diabetic patients: a controlled study显示文摘 | Schofer J Schltiter M Rau T | 2000 | J Am Coll Cardiol2000，35，6： | 1 |
| 19 | CC- chemokine activation in acute pancreatitis: enhanced release of monocyte chemo-attractant protein-1 in patients with local and systemic complications 显示文摘 | RAU B BAUMGART K KRUGER C M | 2003 | Intensive Care Med2003，29，： | 1 |
| 20 | Relation of N-terminal proB-type natriuretic peptide to severity of valvular aortic stenosis显示文摘 | Weber M Arnold R Rau M | 2004 | Am J Cardiol2004，94，6： | 1 |
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