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| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | NSAID use and dementia risk in the Cardiovascular Health Study*: Role of APOE and NSAID type显示文摘 | C A. Szekely J C.S. Breitner A L. Fitzpatrick T D. Rea B M. Psaty L H. Kuller P P. Zandi | 2008 | Neurology2008，，1： | 2 |
| 3 | Differential scanning calorimetry material studies:implications for the safety of lithium-ion cells显示文摘 | ZHANG Z FOUCHARD D REA J R | 1998 | J Power Sources1998，70，： | 1 |
| 4 | Penetrating Wounds of the heart: Analysis of 459 Cases 显示文摘 | Sugg WL Rea W J Ecker RR | 1968 | Thorac Cardiovasc Surg1968，56，： | 1 |
| 5 | Mapping and sequence of the gene for the pseudorabies virus glycoprotein which accumulates in the medium of infected eells显示文摘 | Rea T J Timmins J G Long G W | 1985 | J Virol1985，54，1： | 1 |
| 6 | Dry deposition and foliar leaching of mercury and selected trace elements in deciduous forest throughfall显示文摘 | Rea A W Lindberg S E Keeler G J | 2001 | Atmospheric Environment2001，35，： | 1 |
| 7 | Pesticide sorption onto aquifer sediments 显示文摘 | Rea J E Cooper C S Parker A | 1998 | J of Geochemical Exploration1998，64，： | 1 |
| 8 | Biohydrometallurgical iron oxidation and precipitation: Part I-- Effect of pH on process performance显示文摘 | KAKSONEN A H MORRIS C REA S LI J WYLIE J USHER K M G1NIGE M P CHENG K Y HILARIO F du PLESSIS C A | 2014 | Hydrometallurgy2014，，： | 1 |
| 9 | Differential scanning calor- imetry material studies: implications for the safety of lithium-ion cells显示文摘 | ZHANG Z FOUCHARD D REA J R | 1998 | Journal of Power Sources1998，700，： | 1 |
| 10 | Acidic residues necessary for pyrophosphate-energized pumping and inhibition of the vacuolar H+-pyrophosphatase by N,N'-dicyclohexylcarbodiimide显示文摘 | Zhen R G Kim E J Rea P A | 1997 | Journal of Biological Chemistry1997，272，22： | 1 |
| 11 | A new sphineter- splitting operation for surgical access to low-lying tumors of the rectum显示文摘 | Fingerhut A Rea S Pourcher J | 1988 | Ital J Surg Sci1988，18，1： | 1 |
| 12 | Predicting survival after out- of-hospital cardiac arrest : role of the Utstein data elements 显示文摘 | Rea TD Cook A J Stiell IG | 2010 | Ann Emerg Med2010，55，3： | 1 |
| 13 | Response of bushbean exposed to acid rain mist显示文摘 | Hindawi I J Rea J A Griffis W L | 1980 | American Journalof Botany1980，67，2： | 1 |
| 14 | Dissociation of oceanic methane hydrate as a cause of the carbon isotope ezcursion at the end of the Paleocene显示文摘 | Dickens G R O'Neil J R Rea D K | 1995 | Paleoceanography1995，10，： | 1 |
| 15 | Color rendering: a tale of two metrics显示文摘 | Rea M S Freyssinier-Nova J P | 2008 | Color Research and Application2008，33，3： | 1 |
| 16 | Grain-size distribu-tion function of polymodal sediments in hydraulic and aeoli-an environments,and numerical partitioning of the sedimen-tary components显示文摘 | Sun D H Bloemendal J Rea D K | 2002 | Sedimentary Geology2002，152，34： | 1 |
| 17 | Late Pleistocene paleoclimatology of the central equatorial Pacific: a quantitative record of eolian and carbonate deposition显示文摘 | Chuey J M Rea D K Pisias N G | 1987 | Quatary Research1987，28，： | 1 |
| 18 | Adjuvant tamoxifen and ex- emcstane in early breast cancer (TEAM) : a randomised phase 3 trial 显示文摘 | Van De Velde C J Rea D Seynaeve C et at | 2011 | Lancet2011，377，9762： | 1 |
| 19 | Phase 2 study of subcutaneous omacetaxine mepesuccinate after TKI failure in patients with chronic-phase CML with T315I mutation显示文摘 | Cortes J Lipton JH Rea D | 2012 | Blood2012，120，13： | 1 |
| 20 | Plasma spray formed near-net-shape MoSi2-Si3N4 bulk nanocomposites- structure property evaluation 显示文摘 | Hong S J Viswanatha V N Rea K et ol | 2005 | Materials Science and Engineering2005，404，： | 1 |
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