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| 1 | A human ESC model for MLL-AF4 leukemic fusion gene reveals an impaired early hematopoietic-endothelial specification显示文摘MLL-AF4 熔化基因是在在婴儿的高风险的尖锐成淋巴细胞的白血病的一个特点 genomic 错误。尽管 MLL-AF4 在人的开发期间出生前地产生,这很好被建立,它在在 utero 的造血的开发的效果仍然保持未经勘探。我们创造了一个人特定的细胞的系统在 MLL-AF4-expressing 人的胚胎的干细胞(hESCs ) 学习早 hemato-endothelial 开发。介绍的功能的研究,同种细胞的分析和基因表示表明在 hESCs 的 MLL-AF4 的那表情有 phenotypic,功能并且基因表示影响。MLL-AF4 在 hESCs 充当全球 transcriptional 使活跃之物和 homeobox 基因表示的一个积极管理者。机能上地, MLL-AF4 从 hESCs 提高 hemogenic 先锋的说明,但是强烈损害进一步造血的承诺赞成 endothelial 房间命运。MLL-AF4 hESCs transcriptionally 被告知向对 endothelial 成熟敏感的 hemogenic 先锋区分,由联系到 vascular-endothelial 功能和早造血作用的主人基因的显著 upregulation 思考了。而且,我们报导那 MLL-AF4 表情不是足够的转变导出 hESC 的造血的房间。这个工作说明 hESCs 怎么可以提供唯一的卓见进人的开发并且推进我们理解白血病的熔化基因,知道出生前地产生,调整人的胚胎的造血的说明。 | Clara Bueno Rosa Montes Gustavo J Melen Verdnica Ramos-Mejia Pedro J Real Ver6nica Ayllo'n Laura Sanchez Gertmdis Ligero Inmaculada Gutierrez-Aranda Agustin F Femfindez Mario F Fraga Inmaculada Moreno-Gimeno Deborah Btlrks Maria del Carmen Plaza-Calonge Juan C Rodriguez-Manzaneque Pablo Menendez | 2012 | Cell Research2012，22，6： | 2 |
| 2 | Classification of landscapes using quantitative and categorical data, and prediction of their scenic beauty in North-Western Spain显示文摘 | Real E Arce C Sabucedo J | 2000 | Journal of Environmental Psychology2000，20，： | 1 |
| 3 | Electrochemical impedance spectroscopy study of zinc rich paints on steels in artificial sea water by a transmission line model 显示文摘 | Real S G Elias A C Vilche J R | 1993 | Electrochimica Acta1993，38，14： | 1 |
| 4 | Classification of landscapes using quantitative and categorical data, and prediction of their scenic beauty in North-western Spain显示文摘 | Real E Arce C Sabucedo J M | 2000 | Journal of Environmental Psychology2000，20，： | 1 |
| 5 | Preparation of silica from rice husks 显示文摘 | Real C Alcald M D Criado J M | 1996 | J Am Ceram Soc1996，79，8： | 1 |
| 6 | Fast approximate subspace tracking(FAST)显示文摘 | TUFTS D W REAL E C COOLEY J W | 1997 | IEEE International Conference on ADDP1997，1，： | 1 |
| 7 | Correlation between crystallite size and micro strains in materials subjected to thermal and/or mechanical treatments 显示文摘 | Criado J M Gonzalez M Real C | 1986 | Mater Sci Lett1986，，5： | 1 |
| 8 | 显示文摘 | Navi J A Cerrillos C C Real C | 1996 | Surf Interface Anal1996，24，： | 1 |
| 9 | A polymorphism in the promoter of the tumor necrosis factor alpha gene (-308) is associated with coronary heart disease in type 2 diabetic patients 显示文摘 | Vendrell J Fernandez Real JM Gutierrez C | 2003 | Atherosclemsis2003，167，2： | 1 |
| 10 | Preparation of silica from rice husks显示文摘 | Real C Alcala M D Criado J M | | 0，，08： | 1 |
| 11 | Magnetic resonance imaging of thromgosed dural sinuses显示文摘 | Isensee C Real J Thron A | 1994 | Stroke1994，25，1： | 1 |
| 12 | Fast approximate subspace tracking(FAST) 显示文摘 | Tufts D W Real E C Cooley J W | 1997 | IEEE International Coherence on ADDP1997，1，： | 1 |
| 13 | Gallicacid degradation in aqueous solutions by UV/H2O2treatment, Fenton,s reagent and the photo-Fenton system显示文摘 | Benitez F J Real F J Acero J L Leal A I Garcia C | 2005 | Journal of Hazardous Materials2005，126，： | 1 |
| 14 | Combined environmental and economic dispatch of smart grids using distributed model predictive control显示文摘 | Real A J D Arce A Bordons C | 2014 | Electrical Power and Energy Systems2014，，54： | 1 |
| 15 | Two algorithms for fast approximate subspace tracking显示文摘 | Real E C Tufts D W Cooley J W | 1999 | IEEE Trans on Signal Processing1999，47，7： | 1 |
| 16 | Separation by FPLC chromatofocusing of UDP-glucosyhransferases from three developmental stages of Drosophila melanogaster 显示文摘 | Rausell C Llorca J Real M D | 1997 | Arch Insect Biochem Physiol1997，34，： | 1 |
| 17 | The use of X-ray photoelectron spectroscopy to characterize fine AlN powders submitted to mechanical attrition显示文摘 | FERNANDEZ A REAL C SANCHEZ LOPEZ J Z | 1999 | Nano-Struct Mater1999，11，2： | 1 |
| 18 | Classification of landscapes using quantitative and ategorical data, and prediction of their scenic beauty in North-Western Spain显示文摘 | Real E Arce C Sabucedo J | 2000 | Journal of Environmental Psychology2000，20，： | 1 |
| 19 | The TNF-alpha gene Nco I polymorphism influences the relationship among insulin resistance,percent body fat,and increased serum leptin levels显示文摘 | Fern dez Real J M Gutierre C Ricart W | | 0，，： | 1 |
| 20 | Duration and adherence of antide- pressant treatment (2003 to 2007 ) based on prescription database 显示文摘 | Serna M C Cruz I Real J | 2010 | Eur Psychiatry2010，25，4： | 1 |
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