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| 1 | Assessment of heavy metal pollution from the sediment of Tupilipalem Coast,southeast coast of India显示文摘Sediment from twelve stations was sampled from the Tupilipalem Coast, southeast coast of India, and the presence of a set of heavy metals was established including iron(Fe), manganese(Mn), chromium(Cr),copper(Cu), nickel(Ni), lead(Pb), zinc(Zn) and cadmium(Cd). The heavy metals were assessed by factor analysis, the results of which showed positive and/or negative correlations among Fe, Mn, Cr, Cu, Ni, Pb,Zn, and Cd. Factor analysis also indicated that heavy metals in the sediments of the study area have different natural and anthropogenic sources. Similarly, a sediment pollution assessment was done using the Geoaccumulation Index(Igeo), Enrichment Factor(EF), and Pollution Load Index(PLI). The Geoaccumulation Index indicated that the surface sediment of the Tupilipalem Coast was extremely contaminated with Fe, Mn, Cr, Cu, Ni, Pb, and Zn. The calculation of enrichment factors showed a significant enrichment with respect to Pb, Zn, and Cd and a moderate enrichment with Cr, Cu, and Ni. The falling trend of average contents' enrichment factors is Cd > Pb > Zn > Cu > Cr > Ni > Mn > Fe. The PLI values of the Cd show higher(> 1) values due to the influence of distinct external sources like agricultural runoff, industrial activities, and other anthropogenic inputs. Ninety two percent of heavy metals under study showed the highest concentrations at station TP-5 where the Buckingham Canal and other agricultural and aquacultural effluents connect with the Bay of Bengal. This location is the second inlet which is periodically closed and it seemed that these parts of the study area are heavily affected by anthropogenic pollution. | Sreenivasulu Ganugapenta Jayaraju Nadimikeri Sundara Raja Reddy Balam Chinnapolla Lakshmanna Ballari Rajasekhar Madiga Nirmala K Lakshmi Prasad Tella | 2018 | International Journal of Sediment Research2018，33，3： | 8 |
| 2 | The role of cysteine-rich secretory proteins in male fertility显示文摘充满半胱氨酸的能分泌的蛋白质(CRISPs ) 是 CRISP,的亚群抗原 5 并且 Pr-1 (帽子) 蛋白质总科,并且仅仅在脊椎动物被发现。他们显示出强壮的表示偏爱到哺乳动物的男繁殖的道和有毒的爬行动物的毒液。在男繁殖的道以内, CRISPs 在跨越 haploid 细菌房间开发, epididymal 成熟, capacitation,活动性和授精的实际进程的男细菌房间生物学的许多方面被含有。在结构的水平, CRISPs 由二个领域,一个帽子领域,它在房间鈥揷e ll 粘附被含有,和一个松脆的领域组成,它被显示了越过多重种类调整离子隧道的几个班。此处,我们将在男富饶在 CRISPs 的角色上考察当前的文学,并且由到相关非哺乳动物的蛋白质的推理,推断潜在的生物化学的功能。 | Adam J Koppers Thulasimala Reddy Moira K O'Bryan | 2011 | Asian Journal of Andrology2011，13，1： | 8 |
| 3 | Contrast-enhanced endoscopic ultrasonography显示文摘Contrast agents are increasingly being used to characterize the vasculature in an organ of interest,to better delineate benign from malignant pathology and to aid in staging and directing therapeutic procedures.We review the mechanisms of action of first,second and third generation contrast agents and their use in various endoscopic procedures in the gastrointestinal tract.Various applications of contrast-enhanced endoscopic ultrasonography include differentiating benign from malignant mediastinal lymphadenopathy,assessment of depth of invasion of esophageal,gastric and gall bladder cancers and visualization of the portal venous system and esophageal varices.In addition,contrast agents can be used to differentiate pancreatic lesions.The use of color Doppler further increases the ability to diagnose and differentiate various pancreatic malignancies.The sensitivity of power Doppler sonography to depict tumor neovascularization can be increased by contrast agents.Contrast-enhanced harmonic imaging is a useful aid in identifying the tumor vasculature and studying pancreatic microperfusion.In the future,these techniques could potentially be used to quantify tumor perfusion,to assess and monitor the efficacy of antiangiogenic agents,to assist targeted drug delivery and allow molecular imaging. | Nischita K Reddy Ana Maria Ioncicǎ Adrian Sǎftoiu Peter Vilmann Manoop S Bhutani | 2011 | World Journal of Gastroenterology2011，17，1： | 6 |
| 4 | Liver transplantation for metastatic neuroendocrine tumor: A case report and review of the literature显示文摘Neuroendocrine tumors are divided into gastrointestinal carcinoids and pancreatic neuroendocrine tumors. The WHO has updated the classification of these lesions and has abandoned the term 'carcinoid'. Both types of tumors are divided into functional and non-functional tumors. They are characterized by slow growth and frequent metastasis to the liver and may be limited to the liver for long periods. The therapeutic approach to hepatic metastases should consider the number and distribution of the liver metastases as well as the severity of symptoms related to hormone production and tumor bulk. Surgery is generally considered as the first line therapy. In patients with unresectable liver metastases,alternative treatments are dependent on the type and the growth rate. Initial treatments consist of long acting somatostatin analogs and/or interferon. Streptozocinbased chemotherapy is usually reserved for symptomatic patients with rapidly advancing disease, but generally the therapy is poorly tolerated and its effects are short-lived.Locoregional therapy directed such as hepatic-artery embolization and chemoembolization, radiofrequency thermal ablation and cryosurgery, is often used instead of systemic therapy, if the disease is limited to the liver.However, liver transplantation should be considered in patients with neuroendocrine metastases to the liver that are not accessible to curative or cytoreductive surgery and if medical or locoregional treatment has failed and if there are life threatening hormonal symptoms. We report a case of liver transplantation for metastatic neuroendocrine tumor of unknown primary source and provide a detailed review of the world literature on this controversial topic. | Wojciech C Blonski K Rajender Reddy Abraham Shaked Evan Siegelman David C Metz | 2005 | World Journal of Gastroenterology2005，11，48： | 5 |
| 5 | Nonalcoholic fatty liver disease is associated with benign gastrointestinal disorders显示文摘AIM:To explore associations between nonalcoholic fatty liver disease(NAFLD)and benign gastrointestinal and pancreato-biliary disorders.METHODS:Patient demographics,diagnoses,and hospital outcomes from the 2010 Nationwide Inpatient Sample were analyzed.Chronic liver diseases were identified using International Classification of Diseases,the 9thRevision,Clinical Modification codes.Patients with NAFLD were compared to those with other chronic liver diseases for the endpoints of total hospital charges,disease severity,and hospital mortality.Multivariable stepwise logistic regression analyses to assess for the independent association of demographic,comorbidity,and diagnosis variables with the event of NAFLD(vs other chronic liver diseases)were also performed.RESULTS:Of 7800441 discharge records,32347(0.4%)and 271049(3.5%)included diagnoses of NAFLD and other chronic liver diseases,respectively.NAFLD patients were younger(average 52.3 years vs55.3 years),more often female(58.8%vs 41.6%),less often black(9.6%vs 18.6%),and were from higher income areas(23.7%vs 17.7%)compared to counterparts with other chronic liver diseases(all P<0.0001).Diabetes mellitus(43.4%vs 28.9%),hypertension(56.9%vs 47.6%),morbid obesity(36.9%vs 8.0%),dyslipidemia(37.9%vs 15.6%),and the metabolic syndrome(28.75%vs 8.8%)were all more common among NAFLD patients(all P<0.0001).The average total hospital charge($39607 vs$51665),disease severity scores,and intra-hospital mortality(0.9%vs6.0%)were lower among NALFD patients compared to those with other chronic liver diseases(all P<0.0001).Compared with other chronic liver diseases,NAFLD was significantly associated with diverticular disorders[OR=4.26(3.89-4.67)],inflammatory bowel diseases[OR=3.64(3.10-4.28)],gallstone related diseases[OR=3.59(3.40-3.79)],and benign pancreatitis[OR=2.95(2.79-3.12)]on multivariable logistic regression(all P<0.0001)when the latter disorders were the principal diagnoses on hospital discharge.Similar relationships were observed when the latter disorders were associated diagnoses on hospital discharge.CONCLUSION:NAFLD is associated with diverticular,inflammatory bowel,gallstone,and benign pancreatitis disorders.Compared with other liver diseases,patients with NAFLD have lower hospital charges and mortality. | Srinevas K Reddy Min Zhan H Richard Alexander Samer S El-Kamary | 2013 | World Journal of Gastroenterology2013，19，45： | 4 |
| 6 | Laparoscopic vs open partial colectomy in elderly patients:Insights from the American College of Surgeons- National Surgical Quality Improvement Program database显示文摘AIM: To compare the outcomes between the laparoscopic and open approaches for partial colectomy in elderly patients aged 65 years and over using the American College of Surgeons- National Surgical Quality Improvement Program(ACS NSQIP) database. METHODS: The ACS NSQIP database for the years 2005-2011 was queried for all patients 65 years and above who underwent partial colectomy. 1:1 propensity score matching using the nearest- neighbor method was performed to ensure both groups had similar preoperative comorbidities. Outcomes including postoperative complications, length of stay and mortality were compared between the laparoscopic and open groups. χ2 and Fisher's exact test were used for discrete variables and Student's t-test for continuous variables. P < 0.05 was considered significant and odds ratios with 95%CI were reported when applicable. RESULTS: The total number of patients in the ACS NSQIP database of the years 2005-2011 was 1777035. We identified 27604 elderly patients who underwent partial colectomy with complete data sets. 12009(43%) of the cases were done laparoscopically and15595(57%) were done with open. After propensity score matching, there were 11008 patients each in the laparoscopic(LC) and open colectomy(OC) cohorts. The laparoscopic approach had lower post-operative complications(LC 15.2%, OC 23.8%, P < 0.001), shorter length of stay(LC 6.61 d, OC 9.62 d, P < 0.001) and lower mortality(LC 1.6%, OC 2.9%, P < 0.001). CONCLUSION: Even after propensity score matching, elderly patients in the ACS NSQIP database having a laparoscopic partial colectomy had better outcomes than those having open colectomies. In the absence of specific contraindications, elderly patients requiring a partial colectomy should be offered the laparoscopic approach. | Umashankkar Kannan Vemuru Sunil K Reddy Amar N Mukerji Vellore S Parithivel Ajay K Shah Brian F Gilchrist Daniel T Farkas | 2015 | World Journal of Gastroenterology2015，21，45： | 3 |
| 7 | Effect of Commiphora mukul gum resin on hepatic marker enzymes,lipid peroxidation and antioxidants status in pancreas and heart of streptozotocin induced diabetic rats显示文摘Objective:To study the antioxidant efficacy of Commiphora mukul(C.mukul) gum resin ethanolic extract in streptozotocin(STZ) induced diabetic rats.Methods:The male Wistar albino rats were randomly divided into four groups of eight animals each:Control group(C),CM-treated control group(C_+CMEE),Diabetic control group(D),CM- treated diabetic group(D_+CMEE).Diabetes was induced by intraperitoneal injection of STZ(55 mg/kg/ bwt).After being confirmed the diabetic rats were treated with C.mukul gum resin ethanolic extract(CMEE) for 60 days.The biochemical estimations like antioxidant,oxidative stress marker enzymes and hepatic marker enzymes of tissues were performed.Results:The diabetic rats showed increased level of enzymatic activities aspartate aminotransaminase(AST),alanine aminotransaminase(ALT) in liver and kidney and oxidative markers like lipid peroxidation(LPO) and protein oxidation(PO) in pancreas and heart. Antioxidant enzyme activities were significantly decreased in the pancreas and heart compared to control group.Administration of CMEE(200 mg/kg bw) to diabetic rats for 60 days significantly reversed the above parameters towards normalcy.Conclusions:In conclusion,our data indicate the preventive role of C.mukul against STZ-induced diabetic oxidative stress;hence this plant could be used as an adjuvant therapy for the prevention and/or management of diabetes and aggravated antioxidant status. | Ramesh B Karuna R Sreenivasa Reddy S Haritha K Sai Mangala D Sasi Bhusana Rao B Saralakumari D | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，11： | 3 |
| 8 | The impact of parent brand attribute associations and affect on brand extension evaluation显示文摘 | Sobodh Bhat Srinivas K Reddy | 2001 | Journal of Business Research2001，，3： | 3 |
| 9 | Hepatitis C virus therapy with peg-interferon and ribavirin in Myanmar: A resource-constrained country显示文摘AIM To investigate peg-interferon(peg-IFN) and ribavirin(RBV) therapy in Myanmar and to predict sustained virologic response(SVR).METHODS This single-center, open-label, study was conducted in Myanmar between 2009 and 2014. A total of 288 patients infected with HCV genotypes 1, 2, 3 and 6 were treated with peg-IFN alpha-2a(180 μg/wk) or alpha-2b(50 to 100 μg as a weight-based dose) and RBV as a weight-based dose(15 mg/kg/d). Treatment duration was 48 wk for genotypes 1 and 6, 24 wk for genotype 2, and 24 or 48 wk for genotype 3 based on rapid virologic response(RVR). Those co-infected with hepatitis B received 48 wk of therapy.RESULTS Overall, SVR was achieved for 82% of patients and the therapy was well tolerated. All patients achieved SVR at equivalent rates regardless of HCV genotype(P = 0.314). Low fibrosis scores(P < 0.001), high baseline albumin levels(P = 0.028) and low baseline viral loads(P = 0.029) all independently predicted SVR. On the other hand, IL-28 B TT and CC genotypes were not found to significantly predict SVR(P = 0.634; P = 0.618). Among those who completed treatment, the occurrence of RVR showed a > 96% positive predictive value for achieving SVR. Treatment duration did not significantly impact the likelihood of achieving SVR for patients infected with genotype 3 HCV(P = 0.371). The most common adverse events were fatigue(71%) and poor appetite(60%). Among patients with genotype 3 HCV, more patients in the 48-wk treatment group required erythropoietin than in the 24-wk treatment group(61.1% vs 49.2%).CONCLUSION SVR rates were high with peg-IFN and RBV therapy in Myanmar. Fibrosis scores, baseline albumin, HCV RNA levels and RVR independently predicted SVR. | Naomi Khaing Than Hlaing Debolina Banerjee Robert Mitrani Soe Htet Arker Kyaw San Win Nyan Lin Tun Zaw Thant Khin Maung Win K Rajender Reddy | 2016 | World Journal of Gastroenterology2016，22，43： | 2 |
| 10 | The structural behaviour of layers of SnS grown by spray pyrolysis显示文摘 | Koteswara Reddy N Ramakrishna Reddy K T Fisher G | 1999 | J Phys D: Appl Phys1999，32，： | 2 |
| 11 | 生理性线粒体破碎是心脏适应能量需求增加的正常现象显示文摘线粒体在心脏中起着双重作用:负责满足能量需求和调节细胞凋亡。通常认为,线粒体的分裂和碎裂是病理性应激(如缺血)的结果,是线粒体质量差的指标,并导致线粒体自噬和细胞死亡。然而,最近的研究表明,抑制裂变也导致线粒体功能减弱和心脏损害,说明裂变对维持心脏和线粒体生物能量平衡十分重要。 | 刘莉 叶鹏 Coronado M Fajardo G Nguyen K Zhao M Kooiker KB Jung G Hu DQ Reddy S Sandoval E Stotland A Gottlieb RA Bernstein D | 2018 | 中华高血压杂志2018，26，1： | 2 |
| 12 | NS5A inhibitor, daclatasvir , for the treatment of chronic hepatitis C virus infection显示文摘 | D Alan Herbst K Rajender Reddy | 2013 | Expert Opinion on Investigational Drugs2013，，10： | 2 |
| 13 | Spatial Variability of Soil Properties and Weed Population in the Mississippi Delta 显示文摘 | Gaston L A Locke M A Zablotowicz R M Reddy K N | 1999 | Soil Science Bulletin1999，44，8： | 2 |
| 14 | Isolation of laccase gene-specific sequences from white rot and brown rot fungi by PCR 显示文摘 | D'souza TM Boominathan K Reddy C A | 1996 | ApplEnvironMicrobiol1996，62，10： | 1 |
| 15 | Nutrient removal of selected aquatic maerophytes显示文摘 | Debusk | 1985 | Journal of Environmental Quality1985，14，4： | 1 |
| 16 | ^32P-Postlabeling assay for carcinogen-DNA adducts: Nuclease P1-Mediated enhancement of its sensitivity and applications显示文摘 | I REDDY M V RANDERATH K | 1987 | Environ Health Persp1987，76，： | 1 |
| 17 | Peroxisome proliferator-activated receptor alpha mediates the effects of high-fat diet on hepatic gene expression 显示文摘 | PATSOURIS D REDDY J K MULLER M | 2006 | Endocrinology2006，147，3： | 1 |
| 18 | Optimum part depo-sition orintati-on in fused deposition modeling显示文摘 | Thrimurthulu K Pandey P Reddy N V | 2004 | International Journal of Machine Tools & Manufacture2004，44，： | 1 |
| 19 | Aldolase A and C are ribonucleolytic components of a neuronal complex that regulates the stability of the light neurofilament mRNA 显示文摘 | Canete-soler R Reddy K S Tolan D R | 2005 | J Neurosci2005，25，7： | 1 |
| 20 | Differences in vitro pollen germination and pollen tube growth of cotton cuhivars in response to high temperature显示文摘 | Kakani V G Reddy K R Konti S | 2005 | Annals of Botany2005，96，6： | 1 |
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