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| 1 | Role of HSP-90 for increased nNOS-mediated vasodilation in mesenteric arteries in portal hypertension显示文摘AIM:To explore the role of heat shock protein-90 (HSP-90) for nitrergic vasorelaxation in the splanchnic circulation in rats with and without portal hypertension. METHODS: Neuronal nitric oxide synthase (nNOS) and HSP-90 were analyzed by immunofluorescence, western blotting and co-immunoprecipitation in the mesenteric vasculature and isolated nerves of portal-vein-ligated (PVL) rats and sham operated rats. In vitro perfused de-endothelialized mesenteric arterial vasculature was preconstricted with norepinephrine (EC80) and tested for nNOS-mediated vasorelaxation by periarterial nerve stimulation (PNS, 2-12 Hz, 45V) before and after incubation with geldanamycin (specific inhibitor of HSP-90 signalling, 3 μg/mL) or L-NAME (non-specific NOSblocker, 10-4 mol/L). RESULTS: nNOS and HSP-90 expression was significantly increased in mesenteric nerves from PVL as compared to sham rats. Moreover, nNOS and HSP-90 were visualized in mesenteric nerves by immunofluorescence and immunoprecipitation of nNOS co-immunoprecitated HSP-90 in sham and PVL rats. PNS induced a frequencydependent vasorelaxation which was more pronounced in PVL as compared to sham rats. L-NAME and geldanamycin markedly reduced nNOS-mediated vasorelaxation abrogating differences between the study groups. The effect of L-NAME and geldanamycin on nNOS-mediated vasorelaxation was significantly greater in PVL than in sham animals. However, no difference in magnitude of effect between L-NAME and geldanamycin was noted. CONCLUSION: HSP-90 acts as a signalling mediator of nNOS-dependent nerve mediated vascular responses in mesenteric arteries, and the increased nitrergic vasorelaxation observed in portal hypertension is mediated largely by HSP-90. | Lukas Moleda Lars Jurzik Matthias Froh Erwin Gbele Claus Hellerbrand Rainer H Straub Jürgen Schlmerich Reiner Wiest | 2010 | World Journal of Gastroenterology2010，16，15： | 4 |
| 2 | Prevalence of thyroid disorders in the working population of Germany: ultrasonography screen- ing in 96,278 unselected employees显示文摘 | Reiners C Wegscheider K Schicha H | 2004 | Thyroid2004，14，11： | 1 |
| 3 | Ultrasonography screening in 96, 278 unselected employees 显示文摘 | Reiners C Wegscheider K Schicha H Prevalence of thyroid disorders in the working population of Germany | 2004 | Thyroid2004，14，11： | 1 |
| 4 | Biota and the world carbon budget 显示文摘 | Woodwell G M Whitaker R H Reiners W A | 1978 | Science1978，199，4325： | 1 |
| 5 | Decorative optical coatings 显示文摘 | Reiners G Beck U Jehn H A | 1994 | Thin Solid Films1994，253，： | 1 |
| 6 | The biota and the world carbon budget 显示文摘 | Woodwell G M Whittaker R H Reiners W A | 1978 | Science1978，199，： | 1 |
| 7 | The biota and the world carbon budget显示文摘 | Woodwel G M Whittacker R H Reiners W A etal | 1978 | Science1978，199，： | 1 |
| 8 | FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex显示文摘 | Marta Muzio Arul M Chinnaiyan Frank C Kischkel Karen O’Rourke Andrej Shevchenko Jian Ni Carsten Scaffidi James D Bretz Mei Zhang Reiner Gentz Matthias Mann Peter H Krammer Marcus E Peter Vishva M Dixit | 1996 | Cell1996，，： | 1 |
| 9 | The critical group of a threshold graph显示文摘 | CHRISTIANSON H REINER V | 2002 | Linear Algebra Appl2002，349，： | 1 |
| 10 | Prevalence of thyroid disorders in the working population of Germany: uhrasonography screening in 96 278 unselected employees 显示文摘 | Reiners C Wegscheider K Sehieha H | 2004 | Thyroid2004，14，： | 1 |
| 11 | Histone H3lysine 27methylation asymmetry on developmentallyregulated promoters distinguish the first two lineages in mouse preimplantation embryos显示文摘 | Dahl J A Reiner A H Klungland A | 2010 | PloS one2010，5，2： | 1 |
| 12 | Polychlorinated Biphenyls and Organochlorine Pesticides in Vegetation Samples Collected in Croatia显示文摘 | KRAUTHACKER B ROMANICS H REINER E | 2001 | Bulletin of Environmental Contamination and Toxicology2001，66，3： | 1 |
| 13 | The biota and the world carbon budget显示文摘 | WOODWELL G M WHITAKER R H REINERS W A | 1978 | Science1978，199，： | 1 |
| 14 | Laminar distribution of the cells of origin of the descending tectofugal pathways in the pigeon (Columba livia)显示文摘 | Reiner A Karten H J | 1982 | J Comp Neurol1982，204，： | 1 |
| 15 | A role for the transcriptional repressor Blimp-] in CD8+ T cell exhaustion during chronic viral infection 显示文摘 | Shin H Blackburn SD Intlekofer AM Kao C Angelosan- to JM Reiner SL Wherry El | 2009 | Immunity2009，31，2： | 1 |
| 16 | 9-cis retinoic Ac- id protects against methamphetamine-induced neurotoxic- ity in nigrostriatal dopamine neurons 显示文摘 | REINER D J YU S J SHEN H | 2014 | Neurotox Res2014，25，3： | 1 |
| 17 | Rehabilitation of micturition by transurethral electrostimulation of the bladder in patients with incomplete spinal cord lesions显示文摘 | Madersbacber H Pauer W Reiner E | 1982 | Paraplegia1982，20，4： | 1 |
| 18 | SNPs in the porcine INHA gene and linkage mapping to SSC15显示文摘 | Hiendleder S Reiner G Geldermann H | 2002 | Anita Genet2002，33，3： | 1 |
| 19 | Shakedown and ratcheting under tension-torsion loadings: analysis and experiments 显示文摘 | Heitzer M Staat M Reiners H | 2003 | Nuclear Engineering and Design2003，225，： | 1 |
| 20 | He diffusion and ( U- Th)/He thermochronometry of zircon: Initial results from Fish Canyon Tuff and Gold Butte 显示文摘 | Reiners P W Farley K A Hickes H J I | 2002 | Tectonophysics2002，349，： | 1 |
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