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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | Toxoplasmosis among pregnant women:High seroprevalence and risk factors in Kinshasa,Democratic Republic of Congo显示文摘Objective:To determine the seroprevalence of toxoplasmosis in pregnant women,as well as the proportion of acutely infected and risk factors in the Democratic Republic of Congo.Methods:Thirty maternities in Kinshasa were randomly selected and women attending antenatal consultation were invited to participate.They were interviewed with a structured questionnaire about known risk factors(age,meat consumption,contact with soil,and presence of cat)and a venous blood sample was taken.Sera were analysed for total immunoglobulins(Ig)by VIDAS Toxo Competition using Enzyme Linked Fluorescent Assay.IgM was determined by VIDIA Toxo IgM and IgG avidity by VIDAS Toxo IgG avidity.Results:A total of 781 women were included.Median age was 28 years old(IQR:8.S).And 627women(80.3%;95%CI:77.5-83.1)were found to be positive to total Ig and 17 out of 387(4.4%;95%CI:2.3-6.4)were positive to IgM.IgC avidity was low for 2(11.8%)women,intermediate for 2(11.8%)and high for 13 women(76.4%).There was no statistically significant association between Toxoplasma gondii infection and any risk factors assessed.Conclusion:In Kinshasa,toxoplasmosis endemicity is highly prevalent.One woman out of twenty five had a recent toxoplasmosis infection and 20%were not protected against primoinfection,indicating a need for measures to prevent and control toxoplasmosis during pregnancy. | Doudou Yobi Renaud Piarroux Coralie L'Ollivier Jacqueline Franck Hypolite Situakibanza Hypolite Muhindo Patrick Mitashi Raquel Andreia Inocencio da Luz Marc Van Sprundel Marleen Boelaert Jean-Pierre Van Geertruyden Pascal Lutumba | 2014 | Asian Pacific Journal of Tropical Biomedicine2014，4，1： | 2 |
| 3 | Evaluation of recently isolated Australian tropical microalgae for the enrichment of the dietary value of brine shrimp, Artemia nauplii显示文摘 | Thinh Luong-Van Renaud S M Parry D L | 1999 | Aquaculture1999，170，： | 2 |
| 4 | Approximation algorithms for scheduling malleable tasks under precedence constraints显示文摘 | RENAUD L DENIS T GERHARD J W | 2002 | International Journal of Foundations of Computer Science2002，13，4： | 1 |
| 5 | On neuro-wavelet modeling显示文摘 | MURTAGH F STARCK J L RENAUD O | 2004 | Decision Support Systems2004，37，4： | 1 |
| 6 | Implicit uncertainty propagation for robust collaborative optimization显示文摘 | GU X Y RENAUD J E PENNINGER C L | 2006 | Journal of Mechanical Design2006，128，4： | 1 |
| 7 | The pleiotropic functions of peroxisome proliferator-activated receptor gamma显示文摘 | Debril MB Renaud JP Fajas L | 2001 | J Mol Med2001，79，1： | 1 |
| 8 | Effect of temperature on growth, chemical composition and fatty acid composition of tropical Australian microalgae grown in batch cultures 显示文摘 | RENAUD S M THINH L V LAMBRINIDIS G | 2002 | Aquaculture2002，2，： | 1 |
| 9 | Alpha 1-adrenergic receptor activation depolarizes rat supraoptic neurosecretory neurons in vitro 显示文摘 | Randle J C Bourque C W Renaud L P | 1986 | Physiology1986，251，3： | 1 |
| 10 | Comparison of two multicriteria decision aid methods: Net flow and rough set methods in a high yield pulping process显示文摘 | Renaud J Thibault J Lanouette R l | 2007 | European Journal of Operational Research2007，177，3： | 1 |
| 11 | Design and evaluation of a robotic system for transcranial magnetic stimulation显示文摘 | Zorn L Renaud P Bayle B | | 0，，03： | 1 |
| 12 | Detecting and avoiding oxygen deficient sea water by brown shrimp, Penaeus aztecus, and white shrimp Penaeus setiferus (Lirmaeus)显示文摘 | Renaud M L | 1986 | J Exp Mar Biol Ecol1986，98，3： | 1 |
| 13 | Adaptive experimental design for construction of response surface approximations 显示文摘 | Perez V M Renaud J E Watson L W | 2002 | AIAA Journal2002，40，12： | 1 |
| 14 | Chiral relay effect: 4-substituted 1,3-benzoxazol-2(3H)-ones as achiral templates for enantioselective Diels-Alder reactions 显示文摘 | Quaranta L Corminboeuf O Renaud P | 2002 | Org Lett2002，4，1： | 1 |
| 15 | Activated macrophages inhibit human cytotrophoblast invasiveness in vitro显示文摘 | RENAUD S J POSTOVIT L M MAcDONALDGOODFELLOW S K | 2005 | Biol Reprod2005，73，2： | 1 |
| 16 | BORIS/CTCFL-mediated transcriptional regulation of the hTERT telomerasegene in testicular and ovarian tumor cells显示文摘 | Renaud S Loukinov D Alberti L | 2011 | Nucleic AcidsRes2011，39，3： | 1 |
| 17 | Response to immunotherapy in a 20-month-old boy with anti-NMDA receptor encephalitis 显示文摘 | Wong-Kisiel L C Ji T Renaud D L | 2010 | Neurology2010，74，19： | 1 |
| 18 | Topology Synthesis of Extrusion-based Nonlinear Transient Designs显示文摘 | Patel N M Penninger C L Renaud J E | 2009 | Journal of Mechanical Design2009，131，06： | 1 |
| 19 | Low voltage-activated Ca2+channels are coupled to Ca2+-induced Ca2+release in ratthalamic midline neurons显示文摘 | Richter T A Kolaj M Renaud L P | 2005 | J Neurosci2005，25，36： | 1 |
| 20 | Stereo selective for mation of the varietal aroma compound roseoxide during alcohollic fermentation显示文摘 | KOSLITZ S RENAUD L KOHLER M | 2008 | J Agric Food Chem2008，55，： | 1 |
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