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| 1 | Aerobic bacteria associated with chronic suppurative otitis media in Angola显示文摘Background:Chronic suppurative otitis media(CSOM)is an important cause of hearing loss in children and constitutes a serious health problem globally with a strong association to resource-limited living conditions.Topical antibiotics combined with aural toilet is the first-hand treatment for CSOM but antimicrobial resistance and limited availability to antibiotics are obstacles in some areas.The goal of this study was to define aerobic pathogens associated with CSOM in Angola with the overall aim to provide a background for local treatment recommendations.Methods:Samples from ear discharge and the nasopharynx were collected and cultured from 152 patients with ear discharge and perforation of the tympanic membrane.Identification of bacterial species was performed with matrix-assisted laser desorption/ionization-time of flight mass spectrometry and pneumococci were serotyped using multiplex polymerase chain reactions.Antimicrobial susceptibility testing was done according to EUCAST.Results:One hundred eighty-four samples from ear discharge and 151 nasopharyngeal swabs were collected and yielded 534 and 289 individual isolates,respectively.In all patients,correspondence rate of isolates from 2 ears in patients with bilateral disease was 27.3%and 9.3%comparing isolates from the nasopharynx and ear discharge,respectively.Proteus spp.(14.7%),Pseudomonas aeruginosa(13.2%)and Enterococcus spp.(8.8%)were dominating pathogens isolated from ear discharge.A large part of the remaining species belonged to Enterobacteriaceae(23.5%).Pneumococci and Staphylococcus aureus were detected in approximately 10%of nasopharyngeal samples.Resistance rates to quinolones exceeded 10%among Enterobacteriaceae and was 30.8%in S.aureus,whereas 6.3%of P.aeruginosa were resistant.Conclusions:The infection of the middle ear in CSOM is highly polymicrobial,and isolates found in nasopharynx do not correspond well with those found in ear discharge.Pathogens associated with CSOM in Angola are dominated by gram-negatives including Enterobacteriaceae and P.aeruginosa,while gram-positive enterococci also are common.Based on the results of antimicrobial susceptibility testing topical quinolones would be the preferred antibiotic therapy of CSOM in Angola.Topical antiseptics such as aluminium acetate,acetic acid or boric acid,however,may be more feasible options due to a possibly emerging antimicrobial resistance. | Fabian Udden Matuba Filipe Ake Reimer Maria Paul Erika Matuschek John Thegerstrom Sven Hammerschmidt Tuula Pelkonen Kristian Riesbeck | 2018 | Infectious Diseases of Poverty2018，7，1： | 6 |
| 2 | Successful treatment of fulminant hepatitis B and fulminant hepatitis B and D coinfection explained by inhibitory effect on the immune response?Prog Clin Biol Res显示文摘 | Hansson BG Riesbeck K Nordenfelt E Weiland O | 1991 | 364:421-71991，364，： | 1 |
| 3 | Relapse prevention in first-episode schizophrenia-maintenance vs intermittent drug treatment with prodrome-based early intervention: results of a random- ized controlled trial within the German Research Network on Schizophrenia 显示文摘 | Gaebel W Riesbeck M Wolwer W | 2011 | J Clin Psychiatry2011，72，2： | 1 |
| 4 | Heamophilus influenczeae Uses the Surface Protein E To Acquire Human Plasminogen and To Evade Innate Immunity 显示文摘 | Diana Barthel Birendra Singh Kristian Riesbeck | 2012 | J Immunol2012，188，： | 1 |
| 5 | Regulated endothelial cell expression of novel anticoagulants: a strategy for the prevention and therapy of intravascular thrombosis显示文摘 | Dorling A Chen D Riesbeck K | 2000 | Transplant Proc2000，32，5： | 1 |
| 6 | Clinical xenotrans-plantation of solid organs显示文摘 | Dorling A Riesbeck k Warrens A | 1997 | Lancet1997，349，9055： | 1 |
| 7 | Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization显示文摘 | Popovic R Riesbeck LE Velu CS | 2009 | Blood2009，113，14： | 1 |
| 8 | Glass fibers for stimulated Brillouin scattering and phase conjugation显示文摘 | Meister S Riesbeck T Eichler H J | 2007 | Laser and Particle Beams2007，25，1： | 1 |
| 9 | The hepatitis delta virus显示文摘 | HASSON BG RIESBECK K NORDENFELT E | 1991 | Prog Clin Bio Res1991，364，： | 1 |
| 10 | 联合型钢铁厂废料循环利用的系统性研究显示文摘1前言
本文介绍一个为北欧某联合型钢铁厂开发的系统模型,以及用该模型对一组特定的高炉内部循环利用可行性的评估结果。本项目旨在改善钢铁生产过程中产生的次生材料(如炉渣、粉尘和污泥等)的再利用效果。为此开展了案例分析和研究,包括回收碱性吹氧转炉(BOF)细粒级污泥和精炼炉渣并用之于高炉以及向高炉内喷吹高炉粉尘等。 | Riesbeck J 刘友存 桂满城 | 2016 | 钢铁译文集2016，0，2： | 1 |
| 11 | CP- 115,953 stimulates cytokine production by lymphocytes 显示文摘 | Riesbeck K Forsgren A | 1995 | Antimicrob Agents Chemother1995，39，2： | 1 |
| 12 | Ciprofloxacin upregulate interleukin- 2 at the protein and mRNA levels in murine lymphocytes, but dose not shorten graft survival in a rat cardisc allograft transplantation model 显示文摘 | Riesbeck K Schatz H Ostraat O | 1992 | Transplant Proc1992，24，6： | 1 |
| 13 | Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization显示文摘 | Popovic R Riesbeck LE Velu CS | 2009 | Blood2009，113，： | 1 |
| 14 | Dicloxacillin and erythromycin at high concentrations increase ICAM-1 expression by endothelial cells:a possible factor in the pathogenesis of infusion phlebitis显示文摘 | Lanbeck P Odenholt I Riesbeck K | 2004 | J Antimicrob Chemother2004，53，2： | 1 |
| 15 | Regulation of mir-196b by MLL and its overexpression by MLL fusions contributes to immortalization显示文摘 | Popovic R Riesbeck LE Velu CS | 2009 | Blood2009，113，14： | 1 |
| 16 | Regulation of miR-196b by MLL and its overexpression by MLL fusions contributes to immortalization显示文摘 | Popovic R Riesbeck L E Velu C S | 2009 | Blood2009，113，14： | 1 |
| 17 | Clinical xenotransplantation of solid organs显示文摘 | Dorling A Riesbeck K Warrens A | 1997 | Lancet1997，349，9055： | 1 |
| 18 | Human thrombin and FXa mediate porcine endothelial cell activation;modulation by expression of TFPI-CD4 and hirudin-CD4 fusion proteins 显示文摘 | Riesbeck K McVey J H Geoff K C Edward G D T Robert I L Anthony D | 2001 | Xenotransplantation2001，8，4： | 1 |
| 19 | Regulation of mir- 196b by MLL and its overexpression by MLL fusions contributes to immortalization 显示文摘 | Popovic R Riesbeck LE Velu CS | 2009 | Blood2009，113，14： | 1 |
| 20 | Single dose anti-CD4 monoclonal antibody for induction of tolerance to cardiac allograft in high-and low-responder rat strain combinations显示文摘 | Qi z Riesbeck K Ostraat O | 1997 | Transpl Immunol1997，5，3： | 1 |
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