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| 1 | Splenectomy with chemotherapy vs surgery alone as initial treatment for splenic marginal zone lymphoma显示文摘AIM:To evaluate the clinical characteristics of splenic marginal-zone lymphoma (SMZL) following antigen expression and the influence of therapeutic approaches on clinical outcome and overall survival (OS).METHODS: A total of 30 patients with typical histological and immunohistochemical SMZL patterns were examined. Splenectomy plus chemotherapy was applied in 20 patients, while splenectomy as a single treatment-option was performed in 10 patients. Prognostic factor and overall survival rate were analyzed.RESULTS: Complete remission (CR) was achieved in 20 (66.7%), partial remission (PR) in seven (23.3%), and lethal outcome due to disease progression occurred in three (10.0%) patients. Median survival of patients with a splenectomy was 93.0 mo and for patients with splenectomy plus chemotherapy it was 107.5 mo (Log rank=0.056, P>0.05). Time from onset of first symptoms to the beginning of the treatment (mean 9.4 mo) was influenced by spleen dimensions, as measured by computerized tomography and ultra-sound (t=2.558, P=0.018). Strong positivity (+++) of CD20 antigen expression in splenic tissue had a positive influence on OS (Log rank=5.244, P<0.05). The analysis of factors interfering with survival (by the Kaplan-Meier method) revealed that gender, general symptoms, clinical stage, and spleen infiltration type (nodular vs diffuse) had no significant (P>0.05) effects on the OS. The expression of other antigens (immunohistochemistry) also had no effect on survival-rate, as measured by a χ2 test (P>0.05).CONCLUSION: Initial splenectomy combined with chemotherapy has been shown to be beneficial due to its advanced remission rate/duration; however, a larger controlled clinical study is required to conf irm our findings. | Rajko Milosevic Milena Todorovic Bela Balint Miodrag Jevtic Miodrag Krstic Elizabeta Ristanovic Nebojsa Antonijevic Mirjana Pavlovic Maja Perunicic Milan Petrovic Biljana Mihaljevic | 2009 | World Journal of Gastroenterology2009，15，32： | 2 |
| 2 | Fractal and nonfractal properties of triadic Koch curve 显示文摘 | Milosevic Nebojsa T Ristanovic Dusan | 2007 | Chaos Solitons and Fractals2007，34，4： | 1 |
| 3 | A comparative study of treatments for positional sleep apnea 显示文摘 | Cartwright R Ristanovic R Diaz F | 1991 | Sleep1991，14，： | 1 |
| 4 | Polysomnographic sleep measures in Parkinson's disease patients with treatment-induced hal- lucinations显示文摘 | Comella CL Tanner CM Ristanovic RK | 1993 | Ann Neurol1993，34，： | 1 |
| 5 | Seizures and Renal Failures显示文摘 | Bergen D C Ristanovic R Gorelick P B | 1994 | Int J Artif Organs1994，17，： | 1 |
| 6 | Vagus nerver stimulation for treatment of partial seizures显示文摘 | Ben-Menachem E Manon-Espaillat R Ristanovic R | 1994 | Epilepsia1994，35，： | 1 |
| 7 | A comparative study of treatments for positional sleep apnea显示文摘 | Ristanovic R Diaz F | 1991 | Sleep1991，14，： | 1 |
| 8 | Application of Newton's optimal power flow in voltage/reactive power control显示文摘 | Bjelogrlic M Calovic M S Ristanovic P | 1990 | IEEE Trans on Power Systems1990，5，4： | 1 |
| 9 | Polysomnographic sleep measures in Parkinson' s disease patients with treatment-induced hallucinations显示文摘 | Cornelia CL Tanner CM Ristanovic RK | 1993 | Ann Neurol1993，34，5： | 1 |
| 10 | Complex sleep apnea unmasked by the use of a mandibular advancement device显示文摘 | Kutniar TJ Kovacevic' -Ristanovic' R Freedom T | 2011 | Sleep Breath2011，15，： | 1 |
| 11 | Weight loss in narcolepsy patients treated with sodium oxybate显示文摘 | Husain AM Ristanovic RK Bogan RK | 2009 | Sleep Meal2009，10，6： | 1 |
| 12 | Intelligent control of DC motor driven eleetromeehanical fin actuator显示文摘 | Milan Ristanovic Zarko Cojbasicb Dragan Lazica | 2012 | Con- trol Engineering Practice2012，20，： | 1 |
| 13 | Seizures and renal failures显示文摘 | Bergen DC Ristanovic R Gorelick PB | 1994 | Int J Artif Organs1994，17，： | 1 |
| 14 | Modeling, Simulation, and Control of an Electromechanieal Aerofin Control System with a PWM-Controlled DC Motor 显示文摘 | Ristanovic M R Lazic D V Indjin I | 2008 | Automatic Control and Comput- er Sciences2008，42，4： | 1 |
| 15 | Effects of spatially structured stimulus field on pattern reversal visual evoked potential显示文摘 | Ristanovic C Hajdukovic R | 1981 | Electroenceph Clin Neurophysiol1981，51，： | 1 |
| 16 | A new species of Embellisia isolated from sea water 显示文摘 | Muntanjola-Cvetkovic M Ristanovic B | 1976 | Mycologia1976，68，1： | 1 |
| 17 | Genetic alterations inSMAD4 and K - ras in Serbian patients with endometrial carcinoma 显示文摘 | Nikolic A Ristanovic M Perovic V | 2012 | Int J Gynecol Cancer2012，22，3： | 1 |
| 18 | Vagus nerve stimulation for treatment of partial seizures:A controlled study of effect on seizures显示文摘 | Ben-Menachem E Ma on-Espaillat R Ristanovic R | 1994 | Epilepsia1994，35，3： | 1 |
| 19 | Effects of spatially structured stimulus fields on pattern reversal visual evoked potentials显示文摘 | Ristanovic D Hajdukovic R | 1981 | Electroencephalogr Clin Neurophysiol1981，51，6： | 1 |
| 20 | Surgical treatment of lung sequestration显示文摘 | Cvijanovic V Stanic V Ristanovic A | 2008 | Vojnosanit Pregl2008，65，1： | 1 |
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