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| 1 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 2 | Aminoguanidine impedes human pancreatic tumor growth and metastasis development in nude mice显示文摘AIM:To study the action of aminoguanidine on pancreatic cancer xenografts in relation to cell proliferation,apoptosis,redox status and vascularization.METHODS:Xenografts of PANC-1 cells were developed in nude mice. The animals were separated into two groups:control and aminoguanidine treated. Tumor growth,survival and appearance of metastases were determined in vivo in both groups. Tumors were excised and ex vivo histochemical studies were performed. Cell growth was assessed by Ki-67 expression. Apoptosis was studied by intratumoral expression of B cell lymphoma-2 protein (Bcl-2) family proteins and Terminal deoxynucleotidyl transferase biotin-dUTP Nick End Labeling (Tunel). Redox status was evaluated by the expression of endothelial nitric oxide synthase (eNOS),catalase,copper-zinc superoxide dismutase (CuZnSOD),manganese superoxide dismutase (MnSOD) and glutathione peroxidase (GPx). Finally,vascularization was determined by Massons trichromic staining,and by VEGF and CD34 expression.RESULTS:Tumor volumes after 32 d of treatment by aminoguanidine (AG) were significantly lower than in control mice (P < 0.01). Median survival of AG mice was significantly greater than control animals (P < 0.01). The appearance of both homolateral and contralateral palpable metastases was significantly delayed in AG group. Apoptotic cells,intratumoral vascularization (trichromic stain) and the expression of Ki-67,Bax,eNOS,CD34,VEGF,catalase,CuZnSOD and MnSOD were diminished in AG treated mice (P < 0.01),while the expression of Bcl-2 and GPx did not change.CONCLUSION:The antitumoral action of aminoguanidine is associated with decreased cell proliferation,reduced angiogenesis,and reduced expression of antioxidant enzymes. | Nora A Mohamad Graciela P Cricco Lorena A Sambuco Máximo Croci Vanina A Medina Alicia S Gutiérrez Rosa M Bergoc Elena S Rivera Gabriela A Martín | 2009 | World Journal of Gastroenterology2009，15，9： | 3 |
| 3 | Ag-Zn粉末的机械合金化和随后的热处理(英文)显示文摘研究了在机械合金化过程中Ag和Zn以及随后的热处理中的显微组织演变。机械合金化在SPEX8000D铣床中进行。采用X射线衍射(XRD)﹑透射电子显微镜(TEM)和扫描电子显微镜(SEM)观察样品的显微组织。使用差示扫描量热计(DSC)研究样品的热性能。结果表明,在合金化初期的碾磨过程中能观察到ε,β,β′,α固溶体和剩余的Zn。随后,ε,β,β′和Zn相消失,α固溶体中的Zn浓度剧烈升高。在碾磨7.2ks后,机械合金化过程达到稳定状态。在此期间,α固溶体的组分和晶粒尺寸保持不变。后续热处理表明α固溶体也能够通过机械合金化结合热处理得到。最后,为了得到α固溶体,根据碾磨和热处理过程中样品的微观组织演变,提出一个最佳的工艺路线。 | Danny GUZMN Oscar RIVERA Claudio AGUILAR Stella ORDOEZ Carola MARTíNEZ Daniel SERAFINI Paula ROJAS | 2013 | Transactions of Nonferrous Metals Society of China2013，23，7： | 2 |
| 4 | Age at Onset Should Be a Major Criterion for Subclassification of Colorectal Cancer显示文摘 | José Perea Daniel Rueda Alicia Canal Yolanda Rodríguez Edurne álvaro Irene Osorio Cristina Alegre Bárbara Rivera Joaquín Martínez Javier Benítez Miguel Urioste | 2014 | The Journal of Molecular Diagnostics2014，，1： | 2 |
| 5 | Long-term resveratrol administration reduces metabolic disturbances and lowers blood pressure in obese Zucker rats显示文摘 | Leonor Rivera Rocío Morón Antonio Zarzuelo Milagros Galisteo | 2008 | Biochemical Pharmacology2008，，6： | 2 |
| 6 | PhaseⅡtrial of preoperative irinotecancisplatin followed by concurrent irinotecancisplatin and radio-therapy for respectable locally advanced gastric and esophagogastric junction adenocarcinoma显示文摘 | Rivera F Galán M Tabernero J | 2009 | Int J Radiat Oncol Biol Phys2009，75，5： | 1 |
| 7 | T-bet-dependent S1 P5 expression in NK cells promotes egress from lymph nodes and bone marrow显示文摘 | Jenne C N Enders A Rivera R | 2009 | The Journal of experimental medicine2009，206，11： | 1 |
| 8 | A choline-rich diet improves survival in a rat model of endotoxin Mock显示文摘 | Rivera CA Wheeler MD Enomoto N | 1998 | Am J Physiol Gastrointest Liver Physiol1998，275，4： | 1 |
| 9 | Method of DNA extraction and application of multiplex polymerase chain reaction to detect toxigenic Vibrio cholerae O1 and O139 from aquatic ecosystems 显示文摘 | Rivera I N Lipp E K Gil A | 2003 | Environ Microbiol2003，5，7： | 1 |
| 10 | Detection of large-scale variation in the human genome 显示文摘 | Iafrate A J Feuk L Rivera M N | 2004 | Nature Genetics2004，36，9： | 1 |
| 11 | Laparoscopic splenectomy:outcome and efficacy in 103 consecutive patients显示文摘 | Katkhouda N Hurtwitz MB Rivera RT | 1998 | Ann Surg1998，228，3： | 1 |
| 12 | Toll-like recep- tor-4 signaling and Kupffer cells play pivotal roles in the patho- genesis of non-alcoholic steatohepatitis 显示文摘 | Rivera CA Adegboyega P van Rooijen N | 2007 | J Hepatol2007，47，4： | 1 |
| 13 | On the time polynomial decay in elastic solids with voids显示文摘 | Mu(n)oz Rivera J E Quintanilla R | | 0，，： | 1 |
| 14 | Understanding retinopathy of prematurity:update on pathogenesis显示文摘 | RIVERA JC SAPIEHA P J0YAL JS DUHAMEL F SHAO Z SITARAS N | 2011 | Neonatology2011，100，4： | 1 |
| 15 | Method of DNA extraction and application of multiplex polymerase chain reaction to detect toxigenic Vibrio cholerae O1 and O139 from aquatic ecosystems显示文摘 | Rivera I N G Lipp E K GiL AI | 2003 | Environ Microbiol2003，5，7： | 1 |
| 16 | Intracerebral streptozotocin model of type 3 diabetes:relevance to sporadic Alzheimer' s disease显示文摘 | Lester-coll N Rivera EJ Soscia SJ | 2006 | Alzheimers Dis2006，9，1： | 1 |
| 17 | Stabilization in elastic solids with voids显示文摘 | Pamplona P X Mu(n)oz Rivera J E Quintanilla R | | 0，，： | 1 |
| 18 | Highly efficient synthesis of β-amino acid derivatives via asymmetric hydrogenation of unprotected enamines显示文摘 | Hsiao Y Rivera N R Rosner T | 2004 | J Am Chem Soc2004，126，： | 1 |
| 19 | Treatment of depression in type 2 diabetic patients:effects on depressive symptoms, quality of life and metabolic control 显示文摘 | N icolau J Rivera R Frances C | 2013 | Diabetes Res Clin Pract2013，101，2： | 1 |
| 20 | On the decay of solutions for porous-elastic system with history显示文摘 | Pamplona P X Mu(n)oz Rivera J E Quintanilla R | | 0，，： | 1 |
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