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| 1 | 冲刷作用下砂土地层中桩的侧向力学性质分析显示文摘[目的]冲刷是在水流以及波浪作用下土体流失的一个过程,它通常发生在桥梁、港口码头、以及海岸平台等结构的基础周围,造成基础的承载力下降,危及上部结构的安全。目前在分析桩的侧向力学行为时,只考虑了冲刷深度对桩的侧向承载力的影响,而忽略了冲刷形成的冲刷孔的影响。事实上,冲刷孔的几何形状不仅包括冲刷深度、还包括了冲刷孔的宽度以及冲刷孔的坡度。目前,工程设计中广泛采用的侧向桩分析方法,即p-y曲线方法无法考虑冲刷孔三维几何形状对桩的侧向力学性质的影响。[方法]针对这个问题,文章提出了一种修正的p-y曲线方法以用于分析砂土地层中桩在冲刷作用下的侧向力学响应。[结果]该方法改进了基于锲形体破坏模型的Reese p-y曲线法,从而能考虑冲刷孔三维几何形状的影响。将计算得到的结果与三维有限差分数值分析的结果进行了比较,验证该修正方法的可靠性。[结论]计算结果表明:在冲刷孔的几何形状参数里,冲刷深度对桩的侧向力学性质的影响最大,其次是冲刷孔的宽度与坡度。忽略冲刷孔几何形状的影响,桩在地面位置的侧向位移会增加49%~68%。 | 林城 韩杰 Caroline BENNETT Robert PARSONS | 2018 | 南方能源建设2018，5，2： | 5 |
| 2 | miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting显示文摘 | Christine Esau Scott Davis Susan F. Murray Xing Xian Yu Sanjay K. Pandey Michael Pear Lynnetta Watts Sheri L. Booten Mark Graham Robert McKay Amuthakannan Subramaniam Stephanie Propp Bridget A. Lollo Susan Freier C. Frank Bennett Sanjay Bhanot Brett P. Mo | 2006 | Cell Metabolism2006，，2： | 4 |
| 3 | Lack of hepcidin expression attenuates steatosis and causesfibrosis in the liver显示文摘AIM: To investigate the role of key iron-regulatory protein, hepcidin in non-alcoholic fatty liver disease(NAFLD). METHODS: Hepcidin(Hamp1) knockout and floxed control mice were administered a high fat and high sucrose(HFS) or a regular control diet for 3 or 7 mo. Steatosis, triglycerides, fibrosis, protein and gene expression in mice livers were determined by histological and biochemical techniques, western blotting and realtime polymerase chain reaction. RESULTS: Knockout mice exhibited hepatic iron accumulation. Despite similar weight gains, HFS feeding induced hepatomegaly in floxed, but not knockout, mice. The livers of floxed mice exhibited higher levels of steatosis, triglycerides and c-Jun N-terminal kinase(JNK) phosphorylation than knockout mice. In contrast, a significant increase in fibrosis was observed in knockout mice livers within 3 mo of HFS administration. The hepatic gene expression levels of sterol regulatoryelement-binding protein-1c and fat-specific protein-27, but not peroxisome proliferator-activated receptoralpha or microsomal triglyceride transfer protein, were attenuated in HFS-fed knockout mice. Knockout mice fed with regular diet displayed increased carnitine palmitoyltransferase-1a and phosphoenolpyruvate carboxykinase-1 but decreased glucose-6-phosphatase expression in the liver. In summary, attenuated steatosis correlated with decreased expression of lipogenic and lipid storage genes, and JNK phosphorylation. Deletion of Hamp1 alleles per se modulated hepatic expression of beta-oxidation and gluconeogenic genes. CONCLUSION: Lack of hepcidin expression inhibits hepatic lipid accumulation and induces early development of fibrosis following high fat intake. Hepcidin and iron may play a role in the regulation of metabolic pathways in the liver, which has implications for NAFLD pathogenesis. | Sizhao Lu Robert G Bennett Kusum K Kharbanda Duygu Dee Harrison-Findik | 2016 | World Journal of Hepatology2016，8，4： | 3 |
| 4 | Outcomes and patients' perspectives of transition from paediatric to adult care in inflammatory bowel disease显示文摘AIM: To describe the disease and psychosocialoutcomes of an inflammatory bowel disease(IBD) transition cohort and their perspectives.METHODS: Patients with IBD, aged > 18 years, who had moved from paediatric to adult care within 10 years were identified through IBD databases at three tertiary hospitals. Participants were surveyed regarding demographic and disease specific data and their perspectives on the transition process. Survey response data were compared to contemporaneously recorded information in paediatric service case notes. Data were compared to a similar age cohort who had never received paediatric IBD care and therefore who had not undergone a transition process. RESULTS: There were 81 returned surveys from 46 transition and 35 non-transition patients. No statistically significant differences were found in disease burden, disease outcomes or adult roles and responsibilities between cohorts. Despite a high prevalence of mood disturbance(35%), there was a very low usage(5%) of psychological services in both cohorts. In the transition cohort, knowledge of their transition plan was reported by only 25/46 patients and the majority(54%) felt they were not strongly prepared. A high rate(78%) of discussion about work/study plans was recorded prior to transition, but a near complete absence of discussion regarding sex(8%), and other adult issues was recorded. Both cohorts agreed that their preferred method of future transition practices(of the options offered) was a shared clinic appointment with all key stakeholders. CONCLUSION: Transition did not appear to adversely affect disease or psychosocial outcomes. Current transition care processes could be optimised, with better psychosocial preparation and agreed transition plans. | Alice L Bennett David Moore Peter A Bampton Robert V Bryant Jane M Andrews | 2016 | World Journal of Gastroenterology2016，22，8： | 3 |
| 5 | Consensus Statements for Management of Barrett’s Dysplasia and Early-Stage Esophageal Adenocarcinoma, Based on a Delphi Process显示文摘 | Cathy Bennett Nimish Vakil Jacques Bergman Rebecca Harrison Robert Odze Michael Vieth Scott Sanders Laura Gay Oliver Pech Gaius Longcroft–Wheaton Yvonne Romero John Inadomi Jan Tack Douglas A. Corley Hendrik Manner Susi Green David Al Dulaimi Haythem Ali | 2012 | Gastroenterology2012，，2： | 2 |
| 6 | Serelaxin increases the antifibrotic action of rosiglitazone in a model of hepatic fibrosis显示文摘AIM To determine the effect of combined serelaxin and rosiglitazone treatment on established hepatic fibrosis.METHODS Hepatic fibrosis was induced in mice by carbon tetrachloride administration for 6 wk, or vehicle alone(nonfibrotic mice). For the final 2 wk, mice were treated with rosiglitazone, serelaxin, or both rosiglitazone and serelaxin. Serum liver enzymes and relaxin levels were determined by standard methods. The degree of liver collagen content was determined by histology and immunohistochemistry. Expression of type?Ⅰ?collagen was determined by quantitative PCR. Activation of hepatic stellate cells was assessed by alpha-smoothmuscle actin(SMA) levels. Liver peroxisome proliferator activated receptor-gamma coactivator 1 alpha(PGC1α) was determined by Western blotting.RESULTS Treatment of mice with CCl4 resulted in hepatic fibrosis as evidenced by increased liver enzyme levels(ALT and AST), and increased liver collagen and SMA. Monotherapy with either serelaxin or rosiglitazone for 2 wk was generally without effect. In contrast, the combination of serelaxin and rosiglitazone resulted in significantly improved ALT levels(P < 0.05). Total liver collagen content as determined by Sirius red staining revealed that only combination treatment was effective in reducing total liver collagen(P < 0.05). These results were supported by immunohistochemistry for type?Ⅰ?collagen, in which only combination treatment reduced fibrillar collagen levels(P < 0.05). The level of hepatic stellate cell activation was modestly, but significantly, reduced by serelaxin treatment alone, but combination treatment resulted in significantly lower SMA levels. Finally, while hepatic fibrosis reduced liver PGC1α levels, the combination of serelaxin and rosiglitazone resulted in restoration of PGC1α protein levels.CONCLUSION The combination of serelaxin and rosiglitazone treatment for 2 wk was effective in significantly reducing established hepatic fibrosis, providing a potential new treatment strategy. | Robert G Bennett Ronda L Simpson Frederick G Hamel | 2017 | World Journal of Gastroenterology2017，23，22： | 2 |
| 7 | Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study显示文摘 | Pierre Fenaux Ghulam J Mufti Eva Hellstrom-Lindberg Valeria Santini Carlo Finelli Aristoteles Giagounidis Robert Schoch Norbert Gattermann Guillermo Sanz Alan List Steven D Gore John F Seymour John M Bennett John Byrd Jay Backstrom Linda Zimmerman David M | 2009 | Lancet Oncology2009，，： | 2 |
| 8 | A New Definition of Genetic Counseling: National Society of Genetic Counselors’ Task Force Report显示文摘 | Robert Resta Barbara Bowles Biesecker Robin L. Bennett Sandra Blum Susan Estabrooks Hahn Michelle N. Strecker Janet L. Williams | 2006 | Journal of Genetic Counseling2006，，： | 1 |
| 9 | Mean Platelet Volume as a Risk Factor for Deep Vein Thrombosis ~In An Ethnically Diverse Population显示文摘 | Bennett SA Roberts LN Rogers R | 2010 | Blood ( ASH Annual Meeting Abstracts )2010，116，： | 1 |
| 10 | miR-122 regulation of lipid metabolism revealed by in vivo antisense targeting显示文摘 | Christine Esau Scott Davis Susan F. Murray Xing Xian Yu Sanjay K. Pandey Michael Pear Lynnetta Watts Sheri L. Booten Mark Graham Robert McKay Amuthakannan Subramaniam Stephanie Propp Bridget A. Lollo Susan Freier C. Frank Bennett Sanjay Bhanot Brett P. Mo | 2006 | Cell Metabolism2006，，2： | 1 |
| 11 | Generating requirements for complex embedded systems using state analysis显示文摘 | Miehel D nIhgma Robert D Rasmussen Mahttew B Bennett | 2006 | Acta Astronautica2006，58，12： | 1 |
| 12 | Privacy Amplification by Public Discussion显示文摘 | Bennett C H Brassard G Robert J M | 1988 | SIAM Journal on Computing1988，17，02： | 1 |
| 13 | Privacy Amplification by Public Discussion显示文摘 | Bennett C H Brassard G Robert J M | 1988 | SIAN Journal on Computing1988，17，2： | 1 |
| 14 | Laid off, But Still Loyal: The Influence of Perceived Justice And Organizational Support显示文摘 | STEFANIE E NAUMANN NATHAN BENNETT ROBERT BIES J | 1998 | International Journal of Conflict Management1998，9，4： | 1 |
| 15 | Privacy amplification by public discussion显示文摘 | Bennett C H Brassard G Robert J M | 1988 | SIAM Journal on Computing1988，17，2： | 1 |
| 16 | Privacy amplification by public discussion显示文摘 | Bennett C H Brassard G Robert J M | 1988 | SIAM J on Computing1988，17，2： | 1 |
| 17 | A method to detect and characterize ellipses using the hough transform显示文摘 | BENNETT Nick BURRIDGE Robert SAITO Naoki | 1999 | IEEE Trans on PAMI1999，21，7： | 1 |
| 18 | Critical factors for implementing IS014001 standard in Unit- ed States industrial companies 显示文摘 | Khalid A Babakri robert A Bennett Matthew Franchetti | 2003 | Journal of Cleaner Pro- duction2003，，7： | 1 |
| 19 | The long-term effect of lifestyle interventions to prevent diabetes in the China Da Qing Diabetes Prevention Study: a 20-year follow-up study显示文摘 | Guangwei Li Ping Zhang Jinping Wang Edward W Gregg Wenying Yang Qiuhong Gong Hui Li Hongliang Li Yayun Jiang Yali An Ying Shuai Bo Zhang Jingling Zhang Theodore J Thompson Robert B Gerzoff Gojka Roglic Yinghua Hu Peter H Bennett | 2008 | 2008 (9626)2008，，9626： | 1 |
| 20 | AJC Editor’s Consensus: Selective and Nonselective Nonsteroidal Anti-Inflammatory Drugs and Cardiovascular Risk显示文摘 | Vincent E. Friedewald Joel S. Bennett J. Paul Christo James L. Pool James M. Scheiman Lee S. Simon Vibeke Strand William B. White Gary W. Williams William C. Roberts | 2010 | The American Journal of Cardiology2010，，： | 1 |
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