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| 1 | Anti-tumour necrosis factor agent and liver injury:literature review,recommendations for management显示文摘Abnormalities in liver function tests,including transient and self-limiting hypertransaminasemia,cholestatic disease and hepatitis,can develop during treatment with anti-tumour-necrosis-factor(TNF)therapy.The optimal management of liver injury related to antiTNF therapy is still a matter of debate.Although some authors recommend discontinuing treatment in case of both a rise of alanine aminotransferase more than5 times the upper limit of normal,or the occurrence of jaundice,there are no standard guidelines for the management of anti-TNF-related liver injury.Bibliographical searches were performed in Pub Med,using the following key words:inflammatory bowel disease(IBD);TNF inhibitors;hypertransaminasemia;drugrelated liver injury;infliximab.According to published data,elevation of transaminases in patients with IBD treated with anti-TNF is a common finding,but resolution appears to be the usual outcome.Anti-TNF agents seem to be safe with a low risk of causing severe drugrelated liver injury.According to our centre experience,we found that hypertransaminasemia was a common,mainly self-limiting finding in our IBD cohort and was not correlated to infliximab treatment on both univariate and multivariate analyses.An algorithm for the management of liver impairment occurring during antiTNF treatment is also proposed and this highlights the need of a multidisciplinary approach and suggests liver biopsy as a key-point in the management decision in case of severe rise of transaminases.However,hepatic injury is generally self-limiting and drug withdrawal seems to be an exception. | Roberta Elisa Rossi Ioanna Parisi Edward John Despott Andrew Kenneth Burroughs James O'Beirne Dario Conte Mark Ian Hamilton Charles Daniel Murray | 2014 | World Journal of Gastroenterology2014，20，46： | 7 |
| 2 | Low temperature induced changes in activity and protein levels of the enzymes associated to conversion of starch to sucrose in banana fruit显示文摘 | Roberta Ghedini Der Agopian Fernanda Helena Gon?alves Peroni-Okita Claudinéia Aparecida Soares Janaína Aparecida Mainardi Jo?o Roberto Oliveira do Nascimento Beatriz Rosana Cordenunsi Franco Maria Lajolo Eduardo Purgatto | 2011 | Postharvest Biology and Technology2011，，2： | 2 |
| 3 | Cryptosporidiosis in patients with HIV/AIDS显示文摘 | Roberta M O?Connor Rehaan Shaffie Gagandeep Kang Honorine D Ward | 2011 | AIDS2011，，5： | 1 |
| 4 | Classi- fication of Brazilian honeys by physical and chemical analyti- cal methods and low field nuclear magnetic resonance (LFIH NMR) 显示文摘 | Roberta de O R R Eliane T M Carla da S C | 2014 | LWT- Food Science and Technology2014，55，： | 1 |
| 5 | Impact of the selective estrogen receptor modulator,raloxifene,on neuronal survival and outgrowth following toxic insults associated with aging and Alzheimer's disease显示文摘 | Kathleen O'Neill Shuhua Chen Roberta Diaz Brinton | 2004 | Exp Neurol2004，185，1： | 1 |
| 6 | Prospective Randomized Comparison of Conventional Stress Echocardiography and Real-Time Perfusion Stress Echocardiography in Detecting Significant Coronary Artery Disease显示文摘 | Deepak Thomas Feng Xie Lynette M. Smith Edward O’Leary Kara Smith Joan Olson Kevin Nalty Roberta Hess Michelle Graham Stacey Therrien Thomas R. Porter | 2012 | Journal of the American Society of Echocardiography2012，，： | 1 |
| 7 | Reperfusion induces apoptosis in rabbit cardiomyocytes显示文摘 | Roberta A Gottlie B Katharine O | 1996 | J Clin Invest1996，112，： | 1 |
| 8 | Self-propagating combustion synthesis and plasma spraying deposition of TiC/Fe powders 显示文摘 | ROBERTA L ROBERTO O GIACOMO C | 2003 | Ceramics International2003，29，5： | 1 |
| 9 | Cre-ative Economies,Creative Cities,Asian European Per-spectives显示文摘 | ROBERTA C.Kong L O’Connor J | | 0，，02： | 1 |
| 10 | A REAL-TIME QUANTITATIVE ASSAY FOR HEPATITIS B DNA VIRUS (HBV) DEVELOPED TO DETECT ALL HBV GENOTYPES显示文摘 | Sitnik Roberta Paes ?ngela Mangueira Cristov?o Pitangueira Pinho Jo?o Renato Rebello | 2010 | Revista do Instituto de Medicina Tropical de S茫o Paulo2010，，3： | 1 |
| 11 | Classification of Brazilian honeys by physical and chemical analytical methods and low field nuclear magnetic resonance(LF 1 H NMR)显示文摘 | RIBEIRO ROBERTA D O R ELIANE T C | 2014 | LWT-Food Science and Technology2014，55，： | 1 |
| 12 | The effect of furazolidone on the physico-chemical properties of dimyristoylphosphatidylcholine bilayers: Relevance to anti-leishmanial therapy显示文摘 | Victor Hugo Giendruczak Martins Marisa Raquel Rodrigues Layoan Dantas Mascarenhas Carla Roberta Lopes de Azambuja Julian Londo?o Londo?o Vania Rodrigues de Lima | 2014 | Journal of Molecular Structure2014，，： | 1 |
| 13 | Self-propagating combustion synthesis and plasma spraying deposition of TiC/Fe powders显示文摘 | Roberta L Roberto O Giacomo C | 2003 | Ceramics International2003，29，5： | 1 |
| 14 | Self-propagating com- bustion synthesis and plasma spraying deposition of TiC/Fe powders 显示文摘 | Roberta L Roberto O Giacomo C | 2003 | Ceramics International2003，29，5： | 1 |
| 15 | Recent ad- vances in cardiac hypertrophy 显示文摘 | GIORGIO O t-:I ENA C ROBERTA M | 2000 | Cardiovascular Research2000，，： | 1 |
| 16 | Toll-like receptor 3: implications for proinflammatory microenvironment in human breast cancer显示文摘 | Marla Karine Amarante Karen Braj?o Oliveira Roberta Losi Guembarovski Ana Cristina Silva do Amaral Herrera Alda Losi Guembarovski Walter Jorge Sobrinho Julio Cesar Voltarelli Maria Angelica Ehara Watanabe | 2012 | Molecular Biology Reports2012，，12： | 1 |
| 17 | Recent advances in cardiac hypertrophy显示文摘 | Giorgio O Elena C Roberta M | 2000 | Cardiovasc Res2000，45，： | 1 |
| 18 | A study of polymorphism in milk proteins from local and imported dairy sheep in Australia by capillary electrophoresis显示文摘 | Patrick C Samson O A Roberta B | | 0，，： | 1 |
| 19 | Action of sisal (Agave sisalana, Perrine) extract in the in vitro development of sheep and goat gastrointestinal nematodes显示文摘 | ROBERTA X S CAROLINA S C MARIANA B B MARIA J M LUCIANA M K CAMILA 0 C CLAUDIA M L ALEXSANDRO B ELANE A A SIMONE L B MARIA A O | 2012 | Experimental Parasitology2012，13，： | 1 |
| 20 | Added Value of ^sup 99m^Tc-HMPAO-Labeled Leukocyte SPECT/ CT in the Characterization and Management of Patients with Infectious Endocarditis显示文摘 | Erba Paola A Conti Umberto Lazzeri Elena Sollini Martina Doria Roberta De Tommasi Salvatore M Bandera Francesco Tascini Carlo Menichetti Francesco Dierckx Rudi A J O Signore Alberto Mariani Giuliano | 2012 | EN2012，，8： | 1 |
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