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| 1 | Radioembolization for the treatment of unresectable hepatocellular carcinoma:A clinical review显示文摘Hepatocellular carcinoma(HCC)is the sixth most common cancer in the world.The majority of patients with HCC present with unresectable disease.These patients have historically had limited treatment options secondary to HCC demonstrating chemoresistance to the currently available systemic therapies.Additionally, normal liver parenchyma has shown intolerance to tumoricidal radiation doses,limiting the use of external beam radiation.Because of these limitations,novel percutaneous liver-directed therapies have emerged. The targeted infusion of radioactive microspheres (radioembolization)represents one such therapy. Radioembolization is a minimally invasive transcatheter therapy through which radioactive microspheres are infused into the hepatic arteries that supply tumor. Once infused,these microspheres traverse the hepatic vascular plexus and selectively implant within the tumor arterioles.Embedded within the arterioles, the 90Y impregnated microspheres emit high energy and low penetrating radiation doses selectively to the tumor.Radioembolization has recently shown promise for the treatment of patients with unresectable HCC. The objective of this review article is to highlight twocurrently available radioembolic devices(90Y,188Rh)and provide the reader with a recent review of the literature. | Saad M Ibrahim Robert J Lewandowski Kent T Sato Vanessa L Gates Laura Kulik Mary F Mulcahy Robert K Ryu Reed A Omary Riad Salem | 2008 | World Journal of Gastroenterology2008，14，11： | 14 |
| 2 | High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes显示文摘Screening gene function in vivo is a powerful approach to discover novel drug targets. We present high-throughput screening(HTS) data for 3 762 distinct global gene knockout(KO) mouse lines with viable adult homozygous mice generated using either gene-trap or homologous recombination technologies. Bone mass was determined from DEXA scans of male and female mice at 14 weeks of age and by microCT analyses of bones from male mice at 16 weeks of age. Wild-type(WT) cagemates/littermates were examined for each gene KO. Lethality was observed in an additional 850 KO lines. Since primary HTS are susceptible to false positive findings, additional cohorts of mice from KO lines with intriguing HTS bone data were examined. Aging,ovariectomy, histomorphometry and bone strength studies were performed and possible non-skeletal phenotypes were explored. Together, these screens identified multiple genes affecting bone mass: 23 previously reported genes(Calcr, Cebpb, Crtap, Dcstamp, Dkk1, Duoxa2, Enpp1, Fgf23, Kiss1/Kiss1 r, Kl(Klotho),Lrp5, Mstn, Neo1, Npr2, Ostm1, Postn, Sfrp4, Slc30a5, Slc39a13, Sost, Sumf1, Src, Wnt10b), five novel genes extensively characterized(Cldn18, Fam20 c, Lrrk1, Sgpl1, Wnt16), five novel genes with preliminary characterization(Agpat2, Rassf5, Slc10a7, Slc26a7, Slc30a10) and three novel undisclosed genes coding for potential osteoporosis drug targets. | Robert Brommage Jeff Liu Gwenn M Hansen Laura L Kirkpatrick David G Potter Arthur T Ss Brian Zambrowicz David R Powell Peter Vogel | 2014 | Bone Research2014，2，3： | 7 |
| 3 | Heart Disease and Stroke Statistics—2009 Update: A Report From the American Heart Association Statistics Committee and Stroke Statistics Subcommittee显示文摘 | Donald Lloyd-Jones Robert Adams Mercedes Carnethon Giovanni De Simone T Bruce Ferguson Katherine Flegal Earl Ford Karen Furie Alan Go Kurt Greenlund Nancy Haase Susan Hailpern Michael Ho Virginia Howard Brett Kissela Steven Kittner Daniel Lackland Lynda L | 2009 | Circulation2009，，3： | 4 |
| 4 | Twenty-five years of research on the effects of exercise training in breast cancer survivors:A systematic review of the literature显示文摘AIM:To investigate the role of exercise training the past 25 years on major physiological-psychological outcomes studied thus far in this patient population.METHODS:Pub Med, Medline Plus, the Cochrane Library, Web of Science, SportD iscus, Embase, Scorpus, and Google Scholar were searched from September to November 2013 to identify exercise training studies that used objective measurements of fitness and/or patient reported outcomes assessed pre and post-exercise training with statistical analyses performed in at least one of the following outcome measurements:Cardiorespiratory function, body composition, muscular strength, fatigue, depression, and overall quality of life. Five reviewers independently identified the studies that met the criteria for the review and discrepancies were resolved by consensus among all authors.RESULTS:Fifty-one studies were included in this review with 5 from the period between 1989-1999, 11 from 2000-2006, and 35 from 2007-2013. The evolution of study designs changed from aerobic only exercise training interventions(1989-1999), to a combination of aerobic and resistance training(2000-2006), to studies including an arm of resistance training or examining the effects of resistance training as the main mode of exercise(2007-2013). Overall, the benefits of exercise showed improvements in cardiorespiratory function, body composition, strength, and patient reported outcomes including fatigue, depression, and quality of life.CONCLUSION:Exercise training appears to be safe for most breast cancer patients and improvements in physiological, psychological, and functional parameters can be attained with regular participation in moderate intensity exercise. | Claudio L Battaglini Robert C Mills Brett L Phillips Jordan T Lee Christina E Story Marcelo GB Nascimento Anthony Carl Hackney | 2014 | World Journal of Clinical Oncology2014，5，2： | 3 |
| 5 | ENETS Consensus Guidelines for the Management of Patients with Digestive Neuroendocrine Neoplasms: Functional Pancreatic Endocrine Tumor Syndromes显示文摘 | Jensen Robert T Cadiot Guillaume Brandi Maria L De Herder Wouter W Kaltsas Gregory Komminoth Paul Scoazec Jean-yves Salazar Ramon Sauvanet Alain Kianmanesh Reza | 2012 | Neuroendocrinology2012，，2： | 3 |
| 6 | Positive Management of Differences for Risk Reduction in BOT Projects显示文摘 | ROBERT L K | 2000 | International Journal of Project Management2000，18，4： | 1 |
| 7 | On the theory of flashover development显示文摘 | Graham T L Makhviladze G Roberts J P | 1995 | Fire Safety Journal1995，25，： | 1 |
| 8 | Online selection of discriminative tracking features 显示文摘 | ROBERT T C LIU Y MARIUS L | 2005 | IEEE Transactions on Pattern Analysis and Machine Intelligence2005，27，10： | 1 |
| 9 | Typing of dengue vi- ruses in clinical specimens and mosquitoes by single-tube multiplex reverse transcriptase PCR显示文摘 | Harris E Roberts T G Smith L | 1998 | J Clin Microbiol1998，36，： | 1 |
| 10 | Enteric coated HPMC capsules designed to achieve intestinal targeting显示文摘 | Ewart T Cole Robert A Scott Alyson L Connor Ian R Wilding Hans-U Petereit Carsten Schminke Thomas Beckert Dominique Cadé | 2002 | International Journal of Pharmaceutics2002，，1： | 1 |
| 11 | Bacterial RNA chaperones confer abiotic stress tolerance in plants and improved grain yield in maize under water-limited condition 显示文摘 | Paolo C Dave W Robert J B Don C A Jay H Martin S Mark A Ganesh K Sara S Robert D Santiago N Stephanie B Mary F Jayaprakash T Santanu D Christopher B Michael H L Jacqueline E H | 2008 | Plant Physiology2008，147，2： | 1 |
| 12 | An improved model of potential and current distribution within a flow-through porous electrode 显示文摘 | DOHERTY T SUNDERLAND J G ROBERTS E P L | 1996 | Electrochimica Acta1996，41，4： | 1 |
| 13 | Comparisons andcontrasts of shale gas and tight gas developments, NorthAmerica experience and trends 显示文摘 | Robert L K William N K Daniel T G | 2012 | SPE 1608552012，，： | 1 |
| 14 | Plasma uric acid remains a marker of poor outcome in hypertensive pregnancy: a retrospective cohort study 显示文摘 | HAWKINS T L ROBERTS J M MANGOS G J | 2012 | B JOG- An International Journal of Obstetrics and Gynaecology2012，119，4： | 1 |
| 15 | Improving nutrient use efficiency显示文摘 | Roberts T L | 2008 | Turkish Journal of Agriculture and Forestry2008，32，3： | 1 |
| 16 | Further genetic studies ofresistance to Helminthosporium turcicum Psaa:in maizeby means of chromosomal translocation显示文摘 | JENKINS M T ROBERT A L | 1961 | Crop Scien-ce1961，1，： | 1 |
| 17 | The Control of Single-Celled Cotton Fiber Elongation by Developmentally Reversible Gating of Plasmodesmata and Coordinated Expression of Sucrose and K Transporters and Expansin显示文摘 | RUAN Y L Danny J L Robert T F | 2001 | The Plant Cell2001，13，： | 1 |
| 18 | Reductive elimination of chlorinated ethylenes by zero-valent metals显示文摘 | ROBERTS A L LISA A T WILLIAM A A | 1996 | Environmental Science and Technol-ogy1996，30，8： | 1 |
| 19 | Assessing Dependence : Some Experimental Results 显示文摘 | Robert T Clemen Gregory W Fischer Robert L Winkler | 2000 | Management Science2000，46，8： | 1 |
| 20 | Estimation of sucrose esters(E473) in foods using gas chromatography-mass spectrometry 显示文摘 | Scottera M J Castlea L Roberts D P T | 2006 | Food Additives and Contaminants2006，23，6： | 1 |
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