|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Development of hepatorenal syndrome in bile duct ligated rats显示文摘AIM: To evaluate in bile duct ligated rats whether there were progressive alterations of renal function without changes in histopathology. METHODS: Male Wistar rats were submitted to sham-surgery or bile duct ligation (BDL) and divided according to the post-procedure time (2, 4 and 6-wk). To determine renal function parameters, rats wereplaced in metabolic cages and, at the end of the experiment, blood and urine samples were obtained. Histology and hydroxyproline content were analyzed in liver and renal tissue. RESULTS: Rats with 2 wk of BDL increased free water clearance (P = 0.02), reduced urinary osmolality (P = 0.03) and serum creatinine (P = 0.01) in comparison to the sham group. In contrast, rats at 6 wk of BDL showed features of HRS, including signif icant increase in serum creatinine and reductions in creatinine clearance, water excretion and urinary sodium concentration. Rats with 4 wk of BDL exhibited an intermediate stage of renal dysfunction. Progressive hepatic f ibrosis according to post-procedure time was confirmed by histology. The increased levels of liver hydroxyproline contrasted with the absence of structural changes in the kidney, as assessed by histology and unchanged hydroxyproline content in renal tissue. CONCLUSION: Our data show that BDL produced progressive renal dysfunction without structural changes in the kidney, characterizing HRS. The present model will be useful to understand the pathophysiology of HRS. | Regina M Pereira Robson AS dos Santos Eduardo A Oliveira Virgínia HR Leite Filipi LC Dias Alysson S Rezende Lincoln P Costa Lucíola S Barcelos Mauro M Teixeira Ana Cristina Sim■es e Silva | 2008 | World Journal of Gastroenterology2008，14，28： | 2 |
| 2 | Root hair length determines beneficial effect of a Glomus species on shoot growth of some pasture species 显示文摘 | Schweiger P F Robson A D Barrow N J | 1995 | New Phytologist1995，131，： | 1 |
| 3 | Isolation and partial characterization of the Streptococcus mutans type AⅡ lantibiotic mutacin K8 显示文摘 | ROBSON C L WESCOMBE P A KLESSE N A | 2007 | Microbiology2007，153，5： | 1 |
| 4 | Natural products:potential for developing PheUodendron amurense Bark ex-tract for prostate cancer management显示文摘 | Kumar A P Graham H Robson C | 2010 | Mini Reviews inMedicinal Chemistry2010，10，5： | 1 |
| 5 | Characterization of copper bioreduction and biosorption by a highly copper resistant bacterium isolated from copper-contaminated vineyard soil 显示文摘 | Robson A Simone P Lorraine W Lee MK Flavio AO Camargo BC | 2010 | Sci Total Environ2010，40，8： | 1 |
| 6 | Eone morphogenetic protein 6 in skeletal metastases from prostate cancer and other common human malignancies显示文摘 | Autzen P Robson CN Bjartell A | 1998 | BrJ Cancer1998，78，9： | 1 |
| 7 | The appearance ofproopiomelanocortin early in vertebrate evolution: cloningand sequencing of POMC from a Lamprey pituitary cDNAlibrary 显示文摘 | Heinig J A Keeley F W Robson P | 1995 | General and Comparative Endocrinology1995，99，2： | 1 |
| 8 | Relative toxicities of inorganic, aluminum complexes to barley 显示文摘 | Cameron R S Ritchie G S P Robson A D | 1986 | Soil Sci Soc Am J1986，50，： | 1 |
| 9 | Ionisation Coefficients Measured in Abrupt InP Junctions显示文摘 | UMEBU I CHOUDHURY A N M M ROBSON P N | 1980 | Appl Phys Lett1980，36，： | 1 |
| 10 | Application of land use regression to identify sources and assess spatial variation in urban SVOC concentrations 显示文摘 | MELYMUK L ROBSON M HELM P A | 2013 | Environ Sci Technol2013，47，4： | 1 |
| 11 | Effects of exercise intensity, duration and recovery on in vitro neutrophil function in male athletes显示文摘 | Robson P J Blannin A K Walsh N P | 1999 | Int J Sports Med1999，20，： | 1 |
| 12 | Antici- patory pacing strategies during supramaximal exercise last- ing longer than 30s 显示文摘 | Ansley L Robson P J St Clair Gibson A | 2004 | Med Sci Sports Exerc2004，36，2： | 1 |
| 13 | Spatial variations in throughfall chemistry at the small plot scale显示文摘 | Robson A J Neal C Ryland G P | 1994 | Journal of Hydrology1994，158，： | 1 |
| 14 | PCBs, PBDEs, and PAHs in Toronto air: Spatial and seasonal trends and implications for contaminant transport显示文摘 | Melymuk L Robson M Helm P A | 2012 | Science of the Total Environment2012，429，： | 1 |
| 15 | The effect of intermittent high intensity exercise on blood Zinc status and urinary Zinc exertion显示文摘 | ROBSON P J BLANNIN A K GLEESON M | 1998 | Sports Sci1998，，16： | 1 |
| 16 | Outcome of fetal cerebral posteri- or fossa anomalies显示文摘 | Long A Moran P Robson S | 2006 | Prenat Diagn2006，26，： | 1 |
| 17 | Flavonoids of wyethia section agnorhiza显示文摘 | McCormick S P Robson K A | 1987 | Phytochemistry1987，26，8： | 1 |
| 18 | The Effect of Small Scandium Additions to AA7050 on the As-Cast and Homogenized Microstructure 显示文摘 | Costello F A Robson J D Prangnell P B | 2002 | Materials Science Forum2002，，： | 1 |
| 19 | SME growth: the relationship with business advice and external collaboration 显示文摘 | Robson P J A Bennett R J | 2000 | Small Business Economics2000，15，3： | 1 |
| 20 | On the viability of cyclometalated Ru(11) complexes for lightharvesting applications显示文摘 | Bomben P G Robson K C D Sedach P A | 2009 | Inorganic Chemistry2009，48，20： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员