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| 1 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 2 | Viscoelasticdamping technologies, part I: Modeling and finite elementimplementation 显示文摘 | Vasques C M A * Moreira R A S Rodrigues J D | 2010 | Journal of Advanced Research inMechanical Engineering2010，1，2： | 1 |
| 3 | Spatial and temporal variation of phytoplankton in two subtropical Brazilian reservoirs 显示文摘 | BORGES P A F TRAIN S RODRIGUES L C | 2008 | Hydrobiologia2008，607，： | 1 |
| 4 | Novel core (polyester)-shell (polysaccharide) nanoparticles :protein loading and surface modification with leetins显示文摘 | Rodrigues J S Santos-Magalhaes N S Coelho L C B B | 2003 | Journal of Controlled Release2003，92，： | 1 |
| 5 | Novel core (polyester) -shell (polysaccharide) nanoparticles:protein loading and surface modification with lectins显示文摘 | Rodrigues J S Santos-Magalhes N S Coelho L C B B | 2003 | J Controlled Release2003，92，12： | 1 |
| 6 | Perturbation of membrane dynamics in nerve cells as an early event during bilirubin-induced apoptosis 显示文摘 | RODRIGUES C M SOLA S CASTRO R E | 2002 | J Lipid Res2002，43，6： | 1 |
| 7 | Thermal stress responses in antarctic yeast, glaciozyma antarctica PI12, characterized by real-time quantitative PCR显示文摘 | Boo S Y Wong C M Rodrigues K F | 2013 | Polar Biology2013，36，3： | 1 |
| 8 | Physiological effects of copper in the euryhaline copepod Acartia tonso:Waterborne versus watarborne plus dietborne exposure显示文摘 | Pinho G L Pedroso M S Rodrigues S C | | 0，，01： | 1 |
| 9 | Antioxidant principles and volatile constituents from the north-western iberian mint 'erva-peixeira',mentha cervina显示文摘 | Politi M Rodrigues C L Giao M S | | 0，，12： | 1 |
| 10 | Hierarchical high-silica zeolites as superior base catalysts 显示文摘 | KELLERT C ISABETTINI S VERBOEKEND D RODRIGUES E G PIREA-RAMIREZ J | 2014 | Chemical Science2014，5，2： | 1 |
| 11 | Dynamic behavior and stability of transmission line towers under wind forces显示文摘 | Battista R C Rodrigues R S Pfeil M S | 2003 | Jour nal of Wind Engineering and Industrial Aerodynamics2003，91，8： | 1 |
| 12 | Comparison of two probes for testing susceptibilities of pathogenic yeasts to voriconazole, itraconazole, and caspofungin by flow eytometry显示文摘 | Pina-Vaz C Costa-de-Oliveira S Rodrigues AG | 2005 | J Clin Microbiol2005，43，9： | 1 |
| 13 | Separation by fixed-bed adsorption of hexane isomers in zeolite BETA pellets显示文摘 | PATRICK S B SILVA J A C RODRIGUES A E | 2006 | Ind Eng Chem Res2006，45，12： | 1 |
| 14 | Death receptors and mitochondria: Two prime triggers of neural apoptosis and dif- ferentiation显示文摘 | Sold S Morgado A L Rodrigues C M P | 2013 | Biochimicaet Biophysica Aeta (BBA) GeneralSubjects2013，1830，1： | 1 |
| 15 | Implication of STAT3 signaling in human colonic cancer eells during intestinal trefoil factor 3 (TFF3) -and vascular endothelial growth factor-mediated cellular invasion and tumor growth 显示文摘 | Rivat C Christine R Rodrigues S | 2005 | Cancer Research2005，65，1： | 1 |
| 16 | Mechanism of charged pollutant removal in an ion exchange membrane bioreac- tot: Drinking water dentrification 显示文摘 | Velizarov S Rodrigues C M Reis A M | 2001 | Biotechnol Bioeng2001，71，4： | 1 |
| 17 | Application of the element free Galerkin method to the simulation of plane strain rolling显示文摘 | Xiong S W Rodrigues J M C Martins P A F | 2004 | European Journal of Mechanic A/Solids2004，23，： | 1 |
| 18 | Implication of STAT3 signaling in human colonic cancer cells during intestinal trefoil factor 3 (TFF3)--and vascular endothelial growth factor-mediated cellular invasion and tumor growth显示文摘 | Rivat C Rodrigues S Bruyneel E | 2005 | Cancer Res2005，65，1： | 1 |
| 19 | Dilute-acid hydrolysis for optimization of xylose recovery from rice straw in a semi-pilot reactor显示文摘 | Inês C Roberto Solange I Mussatto Rita C.L.B Rodrigues | 2002 | Industrial Crops & Products2002，，3： | 1 |
| 20 | Evalu- ation of the knowledge of health professionals at a pediatric hospital regarding the use of metered - dose inhalers 显示文摘 | Muchao F P Perin S L R R Rodrigues J C | 2008 | Jornal Brasileiro de Pneumologia2008，34，1： | 1 |
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