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| 1 | High concentration of antimitochondrial antibodies predicts progressive primary biliary cirrhosis显示文摘AIM: To evaluate the serum concentration of antimitochondrial antibodies (AMAs) as a prognostic indicator of progressive primary biliary cirrhosis (pPBC).METHODS: Serum concentrations of AMA subtypes (anti-M2, anti-M4, and anti-M9), biochemical indices of liver function and Mayo risk factor (MRF) were determined in 30 women with diagnosed primary biliary cirrhosis (PBC) selected among 348 females with elevated alkaline phosphatase but without signs of hepatic decompensation.They were followed up for 5 years for possible development of hepatic decompensation.RESULTS: Anti-M2 concentration was significantly correlated with bilirubin and albumin levels as well as MRF, whereas anti-M4 was significantly correlated with albumin level, prothrombin time and MRF. During the 5-year follow-up, progressive PBC (pPBC) was diagnosed in 3 among 23 patients available for evaluation. These 3patients were positive for both anti-M2 and anti-M4.Anti-M2 serum concentration exceeded 1 300 RU/mL in patients with pPBC and only in 1 among 20 non-progressive PBC persons (5%). Anti-M4 serum concentration exceeded 400 RU/mL in 2 of the progressive patients and none in the non-progressive group. In contrast, anti-M9 serum concentration was below 100 RU/mL in all patients with pPBC, and higher than 100 RU/mL in 11 women (55%)among the non-progressive group.CONCLUSION: Females with elevated alkaline phosphatase and high anti-M2 and anti-M4 concentrations are at a high risk for developing pPBC. Quantitative AMA detection should be considered as a method for early diagnosis of pPBC. | Robert Flisiak Maria Pelszynska Danuta Prokopowicz Magdalena Rogalska Urszula Grygoruk | 2005 | World Journal of Gastroenterology2005，11，36： | 16 |
| 2 | Successful antiviral therapy is associated with a decrease of serum prohepcidin in chronic hepatitis C显示文摘AIM: To assess serum concentrations of prohepcidin in chronic hepatitis C individuals and evaluate their associations with disease activity and efficacy of pegylated interferon (PEG-IFN)/ribavirin (RBV) therapy. METHODS: Prohepcidin was measured in sera of 53 chronic hepatitis C patients. Concentrations of prohepcidin and other iron metabolism markers were analyzed at 9 time points before, during and after the end of antiviral therapy. RESULTS: In hepatitis C virus (HCV) genotype 1-infected individuals, a gradual decrease of prohepcidin during antiviral therapy was observed in responders (88.8 ± 14.7 ng/mL before therapy vs 60.6 ± 0.3 ng/mL in the 48th wk, P = 0.04). In contrast, no decrease was observed in non-responders. A similar association was observed in HCV genotype 3a individuals, with a statistically significant decline in serum prohepcidin only in the responder group (99.5 ± 5.2 ng/mL at baseline vs 72.7 ± 6.1 ng/mL in the 24th wk, P = 0.01). Moreover, HCVRNA at week 12 of therapy was positively correlated with baseline (R = 0.63, P < 0.005) and week 12 (R = 0.60, P = 0.01) serum prohepcidin concentrations in HCV genotype 1 infection. CONCLUSION: Successful PEG-IFN/RBV therapy results in a decline of serum prohepcidin concentration in chronic hepatitis C, which may suggest a direct effect of HCV on iron metabolism at the prohormonal level of hepcidin. | Jerzy Jaroszewicz Magdalena Rogalska Iwona Flisiak Robert Flisiak | 2010 | World Journal of Gastroenterology2010，16，14： | 2 |
| 3 | Limit load analysis of perforated disks with square penetration pattern显示文摘 | Rogalska E Kakol W Guerlement G Lambin D | 1997 | Journal of Pressure Vessel Technology-Transactions of the ASME1997，199，1： | 1 |
| 4 | Effect of pso- riasis activity on VEGF and its soluble receptors concen- trations in serum and plaque scales 显示文摘 | Flisiak I Zaniewski P Rogalska M | 2013 | Cytokine2013，61，2： | 1 |
| 5 | Multifocal cutaneous and systemic plasmablastic lymphoma in an infant with combined living donor small bowel and liver transplant 显示文摘 | Apichai S Rogalska A Tzvetanov I | 2009 | Pediatr Transplant2009，13，5： | 1 |
| 6 | Induction of apoptosis in human ovarian cancer cells by new anticancer compounds,epothilone A and B显示文摘 | Rogalska A Marczak A Gajek A | 2013 | Toxicol In Vitro2013，27，1： | 1 |
| 7 | Epothilone B induces human ovarian cancer OV-90 cell apoptosis via external pathway 显示文摘 | Rogalska A Marczak A | 2015 | J Environ Toxicol Pharmacol2015，39，2： | 1 |
| 8 | Gliclazide may have an an- tiapoptotic effect related to its antioxidant properties in human normal and cancer cells显示文摘 | Sliwinska A Rogalska A Szwed M | 2012 | Mol Biol Rep2012，39，5： | 1 |
| 9 | Stereoselective hydrolysis of triglycerides by animal and microbial lipases 显示文摘 | Rogalska E Cudrey C Ferrato F | 1993 | Chirality1993，5，1： | 1 |
| 10 | Incidence of tuberculosis and mycobacteriosis among HIV-infected patients-clinical and epidemiological analysis of patients from north-eastern Poland 显示文摘 | Lucejko M Grzeszczuk A Rogalska M | 2013 | Pneumonol Alergol Pol2013，81，6： | 1 |
| 11 | Limit load analysis of perforated disks with square penetration pattern显示文摘 | Rogalska E Kakoi W Guerlement G | 1997 | Journal of Pressure Vessel Technology1997，1，： | 1 |
| 12 | Activation of apoptotic pathway in normal, cancer ovarian cells by epothi- lone B original research article 显示文摘 | ROGALSKA A SZULA E GAJEK A | 2013 | Environmental Toxicology and Pharmacology2013，36，2： | 1 |
| 13 | Stereoselective hydrolysis of triglycerides by animal and microbial lipases显示文摘 | ROGALSKA E CUDREY C FERRATO F | 1993 | Chirality1993，5，1： | 1 |
| 14 | The mechanism of the osteoprotective action of a polyphenol-rich aronia melanocarpa extract during chronic exposure to cadmium is mediated by the oxidative defense system显示文摘 | BRZóSKA M M ROGALSKA J ROSZCZENKO A | 2016 | Planta Med2016，82，7： | 1 |
| 15 | Effect of neonatal body temperature on postanoxic, potentially neurotoxic iron accumulation in the rat brain 显示文摘 | Rogalska J Danielisova V Caputa M | 2006 | Neurosci Lett2006，393，23： | 1 |
| 16 | Epothilone B induces extrinsic pathway of apoptosis in human SKOV-3 o- varian cancer cells 显示文摘 | ROGALSKA A GAJEK A MARCZAK A | 2014 | Toxicology in Vitro2014，28，4： | 1 |
| 17 | Serum prohepcidin reflects the degree of liver function impairment in liver cirrhosis显示文摘 | Jaroszewicz J Rogalska M Flisiak R | 2008 | Biomarkers2008，13，5： | 1 |
| 18 | Metformin,but not sitagliptin, enhances WP 631-induced apoptotic HepG2 cell death显示文摘 | Sliwinska A Rogalska A Marczak A | 2015 | Toxicol In Vitro2015，29，5： | 1 |
| 19 | Ef- fect of neonatal body temperature on postanoxic, potentially neurotoxic iron ac- cumulation in the rat brain 显示文摘 | Rogalska J Danielisova V Caputa M | 2006 | Neurosci Lett2006，393，23： | 1 |
| 20 | Stereoselective hydrolysis of triglycerides by animal and microbial lipases显示文摘 | Rogalska E Cudrey C Ferrato F | 1993 | Chirality1993，5，1： | 1 |
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