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| 1 | 大别山、苏鲁地区榴辉岩中新发现的微粒金刚石显示文摘以往只在大别山东段安徽省境内新店一带大理岩中榴辉岩内发现过微粒金刚石. 近两年来, 相继在苏鲁地区的毛北、大别山东段新店、老油坊以及北部百丈崖榴辉岩的岩石薄片中和黄尾河榴辉岩的重砂样中发现了微粒金刚石. 薄片中金刚石以包体形式产在石榴子石中, 或产出在石榴子石的颗粒之间. 苏鲁地区的3颗微粒金刚石晶体直径分别为30, 60和120 ?m; 晶形似为八面体以及和立方八面体. 安徽省潜山县新店一颗微粒金刚石的直径180 ?m, 环带结构, 中心为八面体, 环带似为立方八面体的六边形. 新店附近的老油坊榴辉岩中的退变微粒金刚石, 为晶形不明显的集合体, 大部分退变为石墨. 超镁铁岩带内百丈崖榴辉岩中微粒金刚石由2 ~ 3个单颗粒组成直径70 ?m×90 ?m 的集合体, 黄尾河榴辉岩重砂样中发现有直径50 ?m不完整四面体的微粒金刚石. 所有上述各地的微粒金刚石都由Raman光谱证实. 微粒金刚石和其他证据都证明超镁铁岩带与其南部已经证实的超高压变质带一样, 也经历过超高压变质作用, 从而为所建立的大别山几何结构提供了更为确切的证据. | 徐树桐 刘贻灿 陈冠宝 R. Compagnoni F. Rolfo 何谋春 刘惠芳 | 2003 | 科学通报2003，48，10： | 31 |
| 2 | Multisciplinary management of patients with liver metastasis from colorectal cancer显示文摘Colorectal cancer(CRC) is one of the leading causes of cancer-related death. Surgery, radiotherapy and chemotherapy have been till now the main therapeutic strategies for disease control and improvement of the overall survival. Twenty-five per cent(25%) of CRC patients have clinically detectable liver metastases at the initial diagnosis and approximately 50% develop liver metastases during their disease course. Twentythirty per cent(20%-30%) are CRC patients with metastases confined to the liver. Some years ago various studies showed a curative potential for liver metastases resection. For this reason some authors proposed the conversion of unresectable liver metastases to resectable to achieve cure. Since those results were published, a lot of regimens have been studied for resectability potential. Better results could be obtained by the combination of chemotherapy with targeted drugs, such as anti-VEGF and antiEGFR monoclonal antibodies. However an accurate selection for patients to treat with these regimens and to operate for liver metastases is mandatory to reduce the risk of complications. A multidisciplinary team approach represents the best way for a proper patient management. The team needs to include surgeons, oncologists, diagnostic and interventional radiologists with expertise in hepatobiliary disease, molecular pathologists, and clinical nurse specialists. This review summarizes the most important findings on surgery and systemic treatment of CRC-related liver metastases. | Kathleen De Greef Christian Rolfo Antonio Russo Thiery Chapelle Giuseppe Bronte Francesco Passiglia Andreia Coelho Konstantinos Papadimitriou Marc Peeters | 2016 | World Journal of Gastroenterology2016，22，32： | 22 |
| 3 | Helicobacter pylori and pregnancy-related disorders显示文摘Helicobacter pylori(H.pylori)infection is investigated in gastric diseases even during pregnancy.In particular,this Gram-negative bacterium seems to be associated with hyperemesis gravidarum,a severe form of nausea and vomiting during pregnancy.During the last decade,the relationship among H.pylori and several extra-gastric diseases strongly emerged in literature.The correlation among H.pylori infection and pregnancy-related disorders was mainly focused on iron deficiency anemia,thrombocytopenia,fetal malformations,miscarriage,pre-eclampsia and fetal growth restriction.H.pylori infection may have a role in the pathogenesis of various pregnancy-related disorders through different mechanisms:depletion of micronutrients(iron and vitamin B12)in maternal anemia and fetal neural tube defects;local or systemic induction of pro-inflammatory cytokines release and oxidative stress in gastrointestinal disorders and pre-eclampsia;cross-reaction between specific anti-H.pylori antibodies and antigens localized in placental tissue and endothelial cells(preeclampsia,fetal growth restriction,miscarriage).Since H.pylori infection is most likely acquired before pregnancy,it is widely believed that hormonal and immunological changes occurring during pregnancy could activate latent H.pylori with a negative impact not only on maternal health(nutritional deficiency,organ injury,death),but also on the fetus(insufficient growth,malformation,death)and sometime consequences can be observed later in life.Another important issue addressed by investigators was to determine whether it is possible to transmit H.pylori infection from mother to child and whether maternal anti-H.pylori antibodies could prevent infant’s infection.Studies on novel diagnostic and therapeutic methods for H.pylori are no less important,since these are particularly sensitive topics in pregnancy conditions.It could be interesting to study the possible correlation between H.pylori infection and other pregnancy-related diseases of unknown etiology,such as gestational diabetes mellitus,obstetric cholestasis and spontaneous preterm delivery.Since H.pylori infection is treatable,the demonstration of its causative role in pregnancy-related disorders will have important social-economic implications. | Simona Cardaropoli Alessandro Rolfo Tullia Todros | 2014 | World Journal of Gastroenterology2014，20，3： | 12 |
| 4 | Helicobacter pylori's virulence and infection persistence define pre-eclampsia complicated by fetal growth retardation显示文摘AIM: To better understand the pathogenic role of Helicobacter pylori (H. pylori) in pre-eclampsia (PE), and whether it is associated or not with fetal growth retardation (FGR). METHODS: Maternal blood samples were collected from 62 consecutive pregnant women with a diagnosis of PE and/or FGR, and from 49 women with uneventful pregnancies (controls). Serum samples were evaluated by immunoblot assay for presence of specific antibodies against H. pylori antigens [virulence: cytotoxin-associated antigen A (CagA); ureases; heat shock protein B; flagellin A; persistence: vacuolating cytotoxin A (VacA)]. Maternal complete blood count and liver enzymes levels were assessed at delivery by an automated analyzer. RESULTS: A significantly higher percentage of H. pyloriseropositive women were found among PE cases (85.7%) compared to controls (42.9%, P < 0.001). There were no differences between pregnancies complicated by FGR without maternal hypertension (46.2%) and controls. Importantly, persistent and virulent infections (VacA/ CagA seropositive patients, intermediate leukocyte blood count and aspartate aminotransferase levels) were exclusively associated with pre-eclampsia complicated by FGR, while virulent but acute infections (CagA positive/ VacA negative patients, highest leukocyte blood count and aspartate aminotransferase levels) specifically correlated with PE without FGR. CONCLUSION: Our data strongly indicate that persistent and virulent H. pylori infections cause or contribute to PE complicated by FGR, but not to PE without feto-placental compromise. | Simona Cardaropoli Alessandro Rolfo Annalisa Piazzese Antonio Ponzetto Tullia Todros | 2011 | World Journal of Gastroenterology2011，17，47： | 9 |
| 5 | 华北板块东南缘五河杂岩的麻粒岩相变质、部分熔融与交代作用显示文摘华北板块东南缘五河杂岩属于前寒武纪变质基底,出露于蚌埠及相邻地区,主要由变质的镁铁质和长英质火成岩以及表壳岩系组成,并伴生有古元古代片麻状花岗岩和中生代花岗岩类,构成了'蚌埠隆起'。五河杂岩中主要有石榴斜长角闪岩/榴闪岩、石榴麻粒岩、异剥钙榴岩、石榴斜长角闪片麻岩、花岗片麻岩、云母片岩、大理岩和变质砂岩等岩石类型。这些不同类型的变质岩具有类似的峰期变质矿物,如石榴子石、单斜辉石、斜长石、金红石和石英等;结合其锆石U-Pb年龄,表明它们共同经历了古元古代高压麻粒岩相变质作用。石榴斜长角闪岩的石榴子石包体中存在钾长石+斜长石+石英+黑云母等矿物交生体,指示早期花岗质熔体的存在,证明五河杂岩在古元代变质过程中发生了部分熔融作用。此外,部分变基性岩中存在方解石、绿帘石和绿泥石等蚀变矿物,沿石榴子石的裂隙中分布有钾长石+斜长石+石英+黑云母+角闪石等矿物,表明它们经历了含碳酸盐的熔/流体交代作用以及绿帘石化和绿泥石化作用等。遭受过古元古代含碳酸盐的熔/流体交代作用的变基性岩表现为高放射成因Pb同位素组成,而未遭受含碳酸盐的熔/流体交代作用的变基性岩则表现为典型华北板块前寒武纪麻粒岩地体和下地壳包体岩石的低放射成因Pb同位素组成。 | 刘贻灿 王程程 张品刚 GROPPO Chiara ROLFO Franco 王安东 | 2015 | 地球科学与环境学报2015，37，1： | 7 |
| 6 | Partial melting of ultrahigh-pressure metamorphic rocks at convergent continental margins: Evidences, melt compositions and physical effects显示文摘Ultrahigh-pressure(UHP) metamorphic rocks are distinctive products of crustal deep subduction,and are mainly exposed in continental subduction-collision terranes. UHP slices of continental crust are usually involved in multistage exhumation and partial melting, which has obvious influence on the rheological features of the rocks, and thus significantly affect the dynamic behavior of subducted slices. Moreover,partial melting of UHP rocks have significant influence on element mobility and related isotope behavior within continental subduction zones, which is in turn crucial to chemical differentiation of the continental crust and to crust-mantle interaction.Partial melting can occur before, during or after the peak metamorphism of UHP rocks. Post-peak decompression melting has been better constrained by remelting experiments; however, because of multiple stages of decompression, retrogression and deformation, evidence of former melts in UHP rocks is often erased. Field evidence is among the most reliable criteria to infer partial melting. Glass and nanogranitoid inclusions are generally considered conclusive petrographic evidence. The residual assemblages after melt extraction are also significant to indicate partial melting in some cases. Besides field and petrographic evidence, bulk-rock and zircon trace-element geochemical features are also effective tools for recognizing partial melting of UHP rocks. Phase equilibrium modeling is an important petrological tool that is becoming more and more popular in P-T estimation of the evolution of metamorphic rocks; by taking into account the activity model of silicate melt, it can predict when partial melting occurred if the P-T path of a given rock is provided.UHP silicate melt is commonly leucogranitic and peraluminous in composition with high SiO_2,low MgO, FeO, MnO, TiO_2 and CaO, and variable K_2 O and Na_2 O contents. Mineralogy of nanogranites found in UHP rocks mainly consists of plagioclase + K-feldspar + quartz, plagioclase being commonly albite-rich.Trace element pattern of the melt is characterized by significant enrichment of large ion lithophile elements(LILE), depletion of heavy rare earth elements(HREE) and high field strength elements(HFSE),indicating garnet and rutile stability in the residual assemblage. In eclogites, significant Mg-isotope fractionation occurs between garnet and phengite; therefore, Mg isotopes may become an effective indicator for partial melting of eclogites. | Liang-Peng Deng Yi-Can Liu Xiao-Feng Gu Chiara Groppo Franco Rolfo | 2018 | Geoscience Frontiers2018，9，4： | 6 |
| 7 | 北大别的多阶段高温变质作用与部分熔融及其地球动力学过程和大地构造意义显示文摘北大别经历了三叠纪高温超高压变质作用和多阶段折返历史,因而榴辉岩中广泛发育多期减压结构,极少保留早期的超高压变质记录,这为它们不同变质阶段的温度条件估算带来了巨大困难。然而,目前流行的微量元素温度计为北大别榴辉岩的峰期及之后的退变质阶段温度的确定提供了可能性。根据锆石中Ti和金红石中Zr温度计,结合传统矿物对温度计的计算数据,获得了北大别榴辉岩中多阶段高温(>900℃)条件的数据,证明研究区经历了从超高压榴辉岩相→石英榴辉岩相→高压麻粒岩相阶段的高温变质过程。并且,北大别经历了折返初期(207±4Ma)的减压熔融和碰撞后燕山期(约130Ma)的加热熔融作用。长时间的高温变质作用与多期部分熔融也许正是北大别长期难以发现柯石英和有关超高压变质证据等的重要原因。因此,这些成果有助于甄别北大别的岩石成因和演化过程以及大别山多岩片差异折返模型的建立和完善。 | 刘贻灿 邓亮鹏 古晓锋 Groppo C Rolfo F | 2014 | 地质科学2014，49，2： | 5 |
| 8 | Better to be alone than in bad company:The antagonistic effect of cisplatin and crizotinib combination therapy in non-small cell lung cancer显示文摘AIM To investigate the potential benefit of combining the cMET inhibitor crizotinib and cisplatin we performed in vitro combination studies.METHODS We tested three different treatment schemes in four non-small cell lung cancer(NSCLC) cell lines with a different cMET/epidermal growth factor receptor genetic background by means of the sulforhodamine B assay and performed analysis with Calcusyn.RESULTS All treatment schemes showed an antagonistic effect in all cell lines,independent of the cMET status.Despite their different genetic backgrounds,all cell lines(EBC-1,HCC827,H1975 and LUDLU-1) showed antagonistic combination indexes ranging from 1.3-2.7.These results were independent of the treatment schedule.CONCLUSION These results discourage further efforts to combine cMET inhibition with cisplatin chemotherapy in NSCLC. | Nele Van Der Steen Christophe Deben Vanessa Deschoolmeester An Wouters Filip Lardon Christian Rolfo Paul Germonpré Elisa Giovannetti Godefridus J Peters Patrick Pauwels | 2016 | World Journal of Clinical Oncology2016，7，6： | 2 |
| 9 | Chronic kidney disease may be differentially diagnosed from preeclampsia by serum biomarkers显示文摘 | Rolfo A Attini K Nuzzo AM | 2013 | Kidney Int2013，83，1： | 1 |
| 10 | Patients'perception of cancer- re- lated fatigue : results of a survey to assess the impact on their every- day life 显示文摘 | Diaz N Menj6n S Rolfo C | 2008 | Clin Transl Oncol2008，10，11： | 1 |
| 11 | The role of tar- geted therapy for gastrointestinal tumors显示文摘 | Rolfo C Bronte G Sortino G | 2014 | Expert Rev Gastroenterol Hepatol2014，8，8： | 1 |
| 12 | Atorvastatin improves myocardial perfusion in a patient with hyper-cholesterolemia and single-vessel coronary disease显示文摘 | FEOLA M BIGGI A ROLFO F | 2006 | Clin Nucl Med2006，31，： | 1 |
| 13 | M oxygen delivery to hypoxic tissues as a new therapeutic device 显示文摘 | Bisazza A Giustetto P Rolfo A | 2008 | Conf Proc IEEE Eng Med Biol Soc2008，2008，： | 1 |
| 14 | Ultrasound-mediated oxygen de- livery from chitosan nanobubbles显示文摘 | Cavalli R Bisazza A Rolfo A | 2009 | Int J Pharm2009，378，12： | 1 |
| 15 | TNF-αgene promoter polymorphisms and risk of venous thromboembolism in gastrointestinal cancer patients undergoing chemotherapy显示文摘 | Roselli M Ferroni P Rolfo C | 2013 | Ann Oncol2013，24，10： | 1 |
| 16 | Patients' perception of cancer- related fatigue:Results of a survey to assess the impact on their everyday life显示文摘 | Diaz N Menjon-S Rolfo C | 2008 | Clin Transl Onco12008，10，11： | 1 |
| 17 | Novel therapeu-tic strategies for patients with NSCLC that do not respondto treatment with EGFR inhibitors 显示文摘 | Rolfo C Giovannetti E Hong DS | 2014 | Cancer Treat Rev2014，40，8： | 1 |
| 18 | Nucleated red blood cells in term fetuses: reference values using an automated analyzer显示文摘 | Rolfo A Maconi M Cardaropoli S | 2007 | Neonatology2007，92，3： | 1 |
| 19 | Two contrasting eclogite types in the Himalaya: Implications for the Himalayan orogeny显示文摘 | Lombardo B Rolfo F | 2000 | Journal of Geodynamics2000，30，： | 1 |
| 20 | Metamrophic veins with kyanite and quartz in the Zhu-Jia-Chong, Dabie Shan, China显示文摘 | Castelli D Rolfo F Compagnoni R | 1998 | The Island Arc1998，7，： | 1 |
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