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| 1 | Gastric emptying evaluation by ultrasound prior colonoscopy:An easy tool following bowel preparation显示文摘AIM: To investigate the gastric emptying after bowel preparation to allow general anaesthesia. METHODS: A prospective, non-comparative, and nonrandomized trial was performed and registered on Eudra CT database(2011-002953-80) and on www.trial.gov(NCT01398098). All patients had a validated indication for colonoscopy and a preparation using sodium phosphate(NaP) tablets. The day of the procedure, patients took 4 tablets with 250 mL of water every 15 min, three times. The gastric volume wasestimated every 15 min from computed antral surfaces and weight according to the formula of Perlas et al(Anesthesiology, 2009). Colonoscopy was performed within the 6 h following the last intake.RESULTS: Thirty patients were prospectively included in the study from November 2011 to May 2012. The maximum volume of the antrum was 212 mL, achieved 15 min after the last intake. 24%, 67% and 92% of subjects had an antral volume below 20 mL at 60, 120 and 150 min, respectively. 81% of patients had a Boston score equal to 2 or 3 in each colonic segment. No adverse events leading to treatment discontinuation were reported.CONCLUSION: Gastric volume evaluation appeared to be a simple and reliable method for the assessment of gastric emptying. Data allow considering the NaP tablets bowel preparation in the morning of the procedure and confirming that gastric emptying is achieved after two hours, allowing general anaesthesia. | Romain Coriat Vanessa Polin Ammar Oudjit Franck Henri Marion Dhooge Sarah Leblanc Chantal Delchambre Anouk Esch Tessa Tabouret Maximilien Barret Frédéric Prat Stanislas Chaussade | 2014 | World Journal of Gastroenterology2014，20，37： | 6 |
| 2 | Dimensions of hepatocellular carcinoma phenotypic diversity显示文摘Hepatocellular carcinoma(HCC) is the 3^(rd) leading cause of cancer-related death worldwide. More than 80% of HCCs arise within chronic liver disease resulting from viral hepatitis, alcohol, hemochromatosis, obesity and metabolic syndrome or genotoxins. Projections based on Western lifestyle and its metabolic consequences anticipate a further increase in incidence, despite recent breakthroughs in the management of viral hepatitis. HCCs display high heterogeneity of molecular phenotypes, which challenges clinical management. However, emerging molecular classifications of HCCs have not yet formed a unified corpus translatable to the clinical practice. Thus, patient management is currently based upon tumor number, size, vascular invasion, performance status and functional liver reserve. Nonetheless, an impressive body of molecular evidence emerged within the last 20 years and is becoming increasingly available to medical practitioners and researchers in the form of repositories. Therefore, the aim this work is to review molecular data underlying HCC classifications and to organize this corpus into the major dimensions explaining HCC phenotypic diversity. Major efforts have been recently made worldwide toward a unifying 'clinically-friendly' molecular landscape. As a result, a consensus emerges on three major dimensions explaining the HCC heterogeneity. In the first dimension, tumor cell proliferation and differentiation enabled allocation of HCCs to two major classes presenting profoundly different clinical aggressiveness. In the second dimension, HCC microenvironment and tumor immunity underlie recent therapeutic breakthroughs prolonging patients' survival. In the third dimension,metabolic reprogramming, with the recent emergence of subclass-specific metabolic profiles, may lead to adaptive and combined therapeutic approaches. Therefore, here we review recent molecular evidence, their impact on tumor histopathological features and clinical behavior and highlight the remaining challenges to translate our cognitive corpus into patient diagnosis and allocation to therapeutic options. | Romain Désert Natalia Nieto Orlando Musso | 2018 | World Journal of Gastroenterology2018，24，40： | 3 |
| 3 | Molecular phylogenetic analyses of Verticillium fungicola and related species causing dry bubble disease of the cultivated button mushroom,Agaricus bisporus显示文摘 | COLLOPY P D LARGETEAU-MAMOUN M L ROMAINE C P | 2001 | Phytopathology2001，91，： | 1 |
| 4 | Agrobacterium-mediated transformation of Fusarium oxysporum:An efficient tool for insertional mutagenesis and gene transfer显示文摘 | Chen P X Romaine P | 2001 | Phytopathology2001，91，： | 1 |
| 5 | In vitro evidence for the ionoregulatory role of rainbow trout mucus in acid, acid/ aluminiuman and zinc toxicity 显示文摘 | Handy R D Eddy F B Romain G | 1989 | J Fish Bio1989，35，： | 1 |
| 6 | Agrobacterium tumefaciens-mediated transformation of Fusarium oxysprum:an efficient tool for insertional mutagenic and gene transfer显示文摘 | Mullins E D Chen X Romaine P | | 0，，： | 1 |
| 7 | Agrobacterium-Mediated transformation of Fusarium oxysporum: an efficient tool for insertional mutagenesis and gene transfer 显示文摘 | Mullins E D Chen X Romaine P | 2001 | Phytopathology2001，91，2： | 1 |
| 8 | Agrobacteriuzn- mediated transformation of Fusarium oxysporuzn :an effi- cient tool for insertional mutagenesis and genetransfer 显示文摘 | Mullins E D Chen X Romaine P | 2001 | Phytopathology2001，91，： | 1 |
| 9 | Long-term cycling behavior of asymmetric activated carbon/MnO 2 aqueous electrochemical supercapacitor显示文摘 | Thierry Brousse Pierre-Louis Taberna Olivier Crosnier Romain Dugas Philippe Guillemet Yves Scudeller Yingke Zhou Frédéric Favier Daniel Bélanger Patrice Simon | 2007 | Journal of Power Sources2007，，1： | 1 |
| 10 | Molecular phylogenetic analyses of Verticillium fungicola and related species causing dry bubble disease of the cultivated button mushroom, Agadcus bisporus显示文摘 | COLLOPY P D LARGETEAU-MAMOUN M L ROMAINE C P | 2001 | Phytopathology2001，91，： | 1 |
| 11 | A grobacterium tumef aciens-mediated transformation of Fusarium oxy- porum:an efficient tool for insertional mutagenesis and gene transfer 显示文摘 | Mullins E D Chen X Romaine P | 2001 | Phytopathology2001，91，： | 1 |
| 12 | Effect of late percutaneous angioplastic recanalization of total coronary artery occlusion on left ventricular remodeling,EF and RWM显示文摘 | Nicolas D Michael A Romain C | 1996 | Am J Cardiol1996，78，： | 1 |
| 13 | Agrobacterium-mediated transformation of Fusarium oxysporum:Anefficient tool for insertional mutagenesis and genetransfer显示文摘 | Mullins E D Chen X Romaine P | 2001 | Phytopathology2001，91，： | 1 |
| 14 | Review of the liposuc-tion,abdominoplasty,and face-lift mortality and morbidity risk literature显示文摘 | Yoho RA Romaine JJ O'Neil D | | Dermatol Surg0，31，7： | 1 |
| 15 | Agrobactefium-mediated transformation of Fusafiium oxysporum: an efficient tool for inserlional mutagenesis and gene transfer显示文摘 | Mullins E D Chert X Romaine P | 2001 | Phytopathology2001，91，2： | 1 |
| 16 | A grobacteri-um-mediated transformation of Fusarium oxysporum:An efficient tool for insertional mutagenesis and gene transfer显示文摘 | Mullins E D Chen X Romaine P | | 0，，： | 1 |
| 17 | Agrobacte- rium tumefaciens-mediated transformation of Fusarium oxyporum: an efficient tool for insertional mutagenesis and gene transfer 显示文摘 | MULLINS E D CHEN X ROMAINE P | 2001 | Phytopathology2001，91，： | 1 |
| 18 | Agrobacterium-mediatedtransformation of Fusarium oxysporum:An efficient tool for insertional mutagenesis and gene transfer显示文摘 | Mullins E D Chen P X Romaine P | 2001 | Phytopathology2001，91，： | 1 |
| 19 | Long-term cycling behavior of asymmetric activated carbon/MnO 2 aqueous electrochemical supercapacitor显示文摘 | Thierry Brousse Pierre-Louis Taberna Olivier Crosnier Romain Dugas Philippe Guillemet Yves Scudeller Yingke Zhou Frédéric Favier Daniel Bélanger Patrice Simon | 2007 | Journal of Power Sources2007，，1： | 1 |
| 20 | Agrobaeterium 'mediated transformation of Fusarium oxysporum:an effi- cient tool for insertional mutagenesis and gene transfer 显示文摘 | Mullins E D Chen X Romaine P | 2001 | Phytopathology2001，91，2： | 1 |
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