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| 1 | Cytokine production in patients with cirrhosis and TLR4 polymorphisms显示文摘AIM:To analyze the cytokine production by peripheral blood cells from cirrhotic patients with and without TLR4 D299G and/or T399I polymorphisms.METHODS:The study included nine patients with cirrhosis and TLR4 D299G and/or T399I polymorphisms,and 10 wild-type patients matched for age,sex and degree of liver failure.TLR4 polymorphisms were determined by sequence-based genotyping.Cytokine production by peripheral blood cells was assessed spontaneously and also after lipopolysaccharide(LPS)and lipoteichoic acid(LTA)stimulation.RESULTS:Patients with TLR4 polymorphisms had a higher incidence of previous hepatic encephalopathy than wild-type patients(78%vs 20%,P=0.02).Spontaneous production of interleukin(IL)-6 and IL-10 was lower in patients with TLR4 polymorphisms than in wild-type patients[IL-6:888.7(172.0-2119.3)pg/m L vs 5540.4(1159.2-26053.9)pg/m L,P<0.001;IL-10:28.7(6.5-177.1)pg/m L vs 117.8(6.5-318.1)pg/m L,P=0.02].However,the production of tumor necrosis factor-α,IL-6 and IL-10 after LPS and LTA stimulation was similar in the two groups.CONCLUSION:TLR4 polymorphisms were associated with a distinctive pattern of cytokine production in cirrhotic patients,suggesting that they play a role in the development of cirrhosis complications. | Juan Camilo Nieto Elisabet Sánchez Eva Román Silvia Vidal Laia Oliva Carlos Guarner-Argente Maria Poca Xavier Torras Cándido Juárez Carlos Guarner German Soriano | 2014 | World Journal of Gastroenterology2014，20，46： | 5 |
| 2 | Nutritional therapy for hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is the most frequent primary liver cancer and presents together with cirrhosis in most cases.In addition to commonly recognized risk factors for HCC development,such as hepatitis B virus/hepatitis C virus infection,age and alcohol/tobacco consumption,there are nutritional risk factors also related to HCC development including high intake of saturated fats derived from red meat,type of cooking(generation of heterocyclic amines)and contamination of foods with aflatoxins.On the contrary,protective nutritional factors include diets rich in fiber,fruits and vegetables,n-3 polyunsaturated fatty acids and coffee.While the patient is being evaluated for staging and treatment of HCC,special attention should be paid to nutritional support,including proper nutritional assessment and therapy by a multidisciplinary team.It must be considered that these patients usually develop HCC on top of long-lasting cirrhosis,and therefore they could present with severe malnutrition.Cirrhosisrelated complications should be properly addressed and considered for nutritional care.In addition to traditional methods,functional testing,phase angle and computed tomography scan derived skeletal muscle index-L3 are among the most useful tools for nutritional assessment.Nutritional therapy should be centered on providing enough energy and protein to manage the increased requirements of both cirrhosis and cancer.Supplementation with branched-chain amino acids is also recommended as it improves response to treatment,nutritional status and survival,and finally physical exercise must be encouraged and adapted to individual needs. | Astrid Ruiz-Margáin Berenice M Román-Calleja Paulina Moreno-Guillén JoséA González-Regueiro DeyaniraKúsulas-Delint Alejandro Campos-Murguía Nayelli C Flores-García Ricardo Ulises Macías-Rodríguez | 2021 | World Journal of Gastrointestinal Oncology2021，13，10： | 4 |
| 3 | Toll-like receptor 4 polymorphisms and bacterial infections in patients with cirrhosis and ascites显示文摘AIM To assess the relationship between the presence of toll-like receptor 4(TLR4) polymorphisms and bacterial infections in cirrhotic patients with ascites. METHODS We prospectively included consecutive patients with cirrhosis and ascites hospitalized during a 6-year period. Patients with human immunodeficiency virus(HIV) infection or any other immunodeficiency, patients with advanced hepatocellular carcinoma(beyond Milan's criteria) or any other condition determining poor short-term prognosis, and patients with a permanent urinary catheter were excluded. The presence of D299 G and/or T399 I TLR4 polymorphisms was determined by sequencing and related to the incidence and probability of bacterial infections, other complications of cirrhosis, hepatocellular carcinoma, and mortality during follow-up. A multivariate analysis to identify predictive variables of mortality in the whole series was performed. RESULTS We included 258 patients: 28(10.8%) were carriers of D299G and/or T399I TLR4 polymorphisms(polymorphism group) and 230 patients were not(wildtype group). The probability of developing any bacterial infection at one-year follow-up was 78% in the polymorphism group and 69% in the wild-type group(P = 0.54). The one-year probability of presenting infections caused by gram-negative bacilli(51% vs 44%, P = 0.68), infections caused by gram-positive cocci(49% vs 40%, P = 0.53), and spontaneous bacterial peritonitis(29% vs 34%, respectively, P = 0.99) did not differ between the two groups. The oneyear probability of transplant-free survival was 55% in the polymorphism group and 66% in the wild-type group(P = 0.15). Multivariate analysis confirmed that age, Child-Pugh score, active alcohol intake, previous hepatic encephalopathy, hepatocellular carcinoma and serum creatinine were associated with a higher risk of death during follow-up. CONCLUSION Genetic polymorphisms D299 G and/or T399 I of TLR4 do not seem to play a relevant role in the predisposition of cirrhotic patients with ascites to bacterial infections. | Edilmar Alvarado-Tapias Carlos Guarner-Argente Elida Oblitas Elisabet Sánchez Silvia Vidal Eva Román Mar Concepción Maria Poca Cristina Gely Oana Pavel Juan Camilo Nieto Cándido Juárez Carlos Guarner Germán Soriano | 2018 | World Journal of Hepatology2018，10，1： | 3 |
| 4 | Vascular dementia may be the most common form of dementia in the elderly显示文摘 | Román G C | 2002 | J Neurol Sci2002，，1： | 2 |
| 5 | Heparanase: a new metastasis-associated antigen recognized in breast cancer patients by spontaneously induced memory T lymphocytes显示文摘 | Sommerfeldt N Beckhove P Ge Y Sehutz F Choi C Bucur M Domsehke C Sohn C Sehneeweis A Rom J Poll- mann D Leneht D Vlodavsky I Sehirrmaeher V | 2006 | Cancer Res2006，66，15： | 1 |
| 6 | Parkinson' s disease i n China:Prevalen ce in Beijin g, Xi'an, and Shanghai显示文摘 | Zhang Z X Rom an G C Hong Z | 2005 | Lancet2005，365，9459： | 1 |
| 7 | Power system static-state estimation:Part I,II&III显示文摘 | Schweppe F C Wildes J Rom D B | 1970 | IEEE Transactions on Power Apparatus and Systems1970，89，1： | 1 |
| 8 | The influence of summer pruning current season shoots on growth, floral bud development and winter injury of mature peach trees显示文摘 | ROM C M FERREE D C | 1984 | HortSci1984，19，： | 1 |
| 9 | M anagem ent of m enom etrurrhagia in wom an with and without pregnancy intention:hierarchy of therapies显示文摘 | ROM AN H LOISEL C PUSCASIU L | 2008 | Gynecol Obstet Biol Reprod(Paris)2008，37，8： | 1 |
| 10 | Power system static-state estimation, part Ⅰ~Ⅲ显示文摘 | Schweppe F C Wildes J Rom D B | 1970 | IEEE Transactions on Power Apparatus and Systems1970，89，1： | 1 |
| 11 | ‘Bing’sweet cherry显示文摘 | Roper T R Rom C R | 1990 | Fruit Varieties Journal1990，44，3： | 1 |
| 12 | Power system stat- ic state estimation, parts 1, 2, 3显示文摘 | Schweppe F C Wildes J Rom D B | 1970 | IEEE Transactions on Power Apparatus and Systems1970，89，1： | 1 |
| 13 | Power system static-state estimation, part Ⅰ~Ⅲ显示文摘 | Schweppe F C Wildes J Rom D B | 1970 | IEEE Transactions on Power Apparatus and Systems1970，89，1： | 1 |
| 14 | The role of MAPK signal transduction pathways in the response to oxidative stress in the fungal pathogen Candida albicans: implications in virulence 显示文摘 | de Dios C H Rom(m E Monge R A | 2010 | Curr Protein Pept Sci2010，11，8： | 1 |
| 15 | Causes and possible controls of sun- burn on apples显示文摘 | Simpson J Rom C R Patterson M | 1988 | Good Fruit Grower1988，39，2： | 1 |
| 16 | Comparison of phenolic content of ‘Liberty' apple(Malus×domestica) on various root stocks显示文摘 | Garcia E Rom C R Murphy J B | 2004 | Acta Horticulturae2004，，1： | 1 |
| 17 | Comparison of phenolic content ofLiberty'apple (Malus~domestica) on various root stocks显示文摘 | Garcia E Rom C R Murphy J B | 2004 | Acta Horticulturae2004，658，1： | 1 |
| 18 | From biomarkers to population responses in Nereis diversicolor:Assessment of stress in estuarine ecosystems显示文摘 | DUROU C SMITH B D ROMO M | 2007 | Ecotoxicology and Environmental Safety2007，66，： | 1 |
| 19 | Effect of potassium content in the activity of K-promoted Ni/Al2O3 catalysts for the dry reforming of methane显示文摘 | JUAN-JUAN J ROMN-MARTNEZ M C ILLN-GMEZ M J | 2006 | Appl Catal A:General2006，301，1： | 1 |
| 20 | Fuzzy differential equations and the extension principle显示文摘 | Misukoshi M Chalco-Cano Y Rom'an-Flores H and Bassanezi 1% C | 2007 | Information Sciences2007，177，： | 1 |
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