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181篇 您的检索式：作者名="Roncarolo"

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	题名	作者	年代	出处	被引量
1	Coexpression of CD163 and CD141 identifies human circulating IL-10-producing dendritic cells (DC-10)显示文摘Tolerogenic dendritic cells(DCs)are key players in maintaining immunological homeostasis,dampening immune responses,and promoting tolerance.DC-10,a tolerogenic population of human IL-10-producing DCs characterized by the expression of HLA-G and ILT4,play a pivotal role in promoting tolerance via T regulatory type 1(Tr1)cells.Thus far,the absence of markers that uniquely identify DC-10 has limited in vivo studies.By in vitro gene expression profiling of differentiated human DCs,we identified CD141 and CD163 as surface markers for DC-10.The coexpression of CD141 and CD163 in combination with CD14 and CD16 enables the ex vivo isolation of DC-10 from the peripheral blood.CD14+CD16+CD141+CD163+cells isolated from the peripheral blood of healthy subjects(ex vivo DC-10)produced spontaneously and upon activation of IL-10 and limited levels of IL-12.Moreover,in vitro stimulation of allogeneic naive CD4+T cells with ex vivo DC-10 induced the differentiation of alloantigen-specific CD49b+LAG-3+Tr1 cells.Finally,ex vivo DC-10 and in vitro generated DC-10 exhibited a similar transcriptional profile,which are characterized by an anti-inflammatory and pro-tolerogenic signature.These results provide new insights into the phenotype and molecular signature of DC-10 and highlight the tolerogenic properties of circulating DC-10.These findings open the opportunity to track DC-10 in vivo and to define their role in physiological and pathological settings.	Michela Comi Daniele Avancini Francesca Santoni de Sio Matteo Villa Molly Javier Uyeda Matteo Floris Daniela Tomasoni Alessandro Bulfone Maria Grazia Roncarolo Silvia Gregori	2020	Cellular & Molecular Immunology2020，17，1：	4
2	Differentiation of T regulatory cells by immature dendritic cells.显示文摘	Roncarolo MG Bacchetta RC Bordignon S		0，，：	2
3	Human cd25(+)cd4(+)t regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function显示文摘	Levings MK Sangregorio R Roncarolo MG	2001	J Exp Med2001，193，11：	1
4	Human CD25+CD4+T regulatory cells suppress naive and memory T cellproliferation and can be expanded in vitro without loss of function 显示文摘	Levings MK Sangregorio R Roncarolo MG	2001	J Exp Med2001，193，11：	1
5	Human CD25^+ CD4^+ T regulatory cells suppress naive and memory T cell Proliferation and can be expanded in vitro without loss of function 显示文摘	LEVINGS M K SANGREGORIO R RONCAROLO M G	2001	J Exp Med2001，193，11：	1
6	High spontaneous IL-10 production in unrelated bone marrow transplant recipients is associated the fewer transplant - related complications and early deaths显示文摘	Baker KS Roncarolo MG Peters C	1999	J Bone Marrow Transplant1999，23，5：	1
7	Differentiation of T regulatory cells by immature dendritic cells 显示文摘	RONCAROLO M G LEVINGS M K TRAVERSARI C	2001	J Exp Med2001，193，2：	1
8	Human CD25 ( + ) CD4 ( + ) T regulatory cells suppress naive and memory T cell pro- hferation and can be expanded in vitro without loss of function 显示文摘	Levings MK Sangregorio R Roncarolo MG	2001	J Exp Med2001，193，11：	1
9	The role of different subsets of T regulatory cells in controlling autoimmunity显示文摘	Roncarolo MG Levings MK	2000	Curr Opinion Immunol2000，12，6：	1
10	Rapamycin selectively expands CD4^+ CD25^+ FoxP3^+ regulatory T cells 显示文摘	Battaglia M Stabilini A Roncarolo MG	2005	Blood2005，105，：	1
11	Type 1 T regulatory cells and their relationship with CD4^+ CD25^+ T regulatory cells显示文摘	Roncarolo MG Gregori S Levings M	2003	Novartis Found Syrup2003，252，：	1
12	The role of different subsets of T regulatory cells in controlling autoimmunity显示文摘	Roncarolo MG Levings MK	2000	Curr Opinion Immunol2000，12，6：	1
13	Interleukin-lO-sem'e- ting type 1 regulatory T cells in rodents and humans 显示文摘	Roncarolo MG Gregori S Battaglia M	2006	Immunol Rev2006，212，：	1
14	Type 1 T regulatory cells and their relationship with CD4+CD2s+ T regulatory ceils 显示文摘	Roncarolo MG Gregori S Levings M	2003	Novartis Found Symp2003，，252：	1
15	T-regulatory 1 cells:a novel subset of CD4 T cells with immunoregulatory properties显示文摘	Levings MK Roncarolo MG	2000	J Allergy Clin Immunol2000，，：	1
16	CID4^+ regulatory T cells : mecha-nisms of induction and effector function 显示文摘	Bacchetta R Gregori S Roncarolo MG	2005	Autoimmun Rev2005，4，8：	1
17	Interleukin-10-secreting type 1 regulatory T cells in rodents and humans显示文摘	Roncarolo MG Gregori S Battaglia M	2006	Immunol Rev2006，212，：	1
18	Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans显示文摘	Roncarolo MG Battaglia M	2007	Nat Rev Immunol2007，7，8：	1
19	Human CD25^+ CD4^+ T regulatory cells suppress naive and memory T cell proliferation and can be expanded in vitro without loss of function显示文摘	Levings M Sangregorio R Roncarolo MG	2001	J Exp Med2001，193，11：	1
20	T-regulatory 1 cells: a novel subset of CD4 T cells with immunoregulatory properties显示文摘	Roncarolo MG	2000	J Allergy Clin Immunol2000，106，12：	1

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