|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Morphological study on colonic pathology in ulcerative colitis treated by moxibustion显示文摘AIM To observe the therapeutic effect ofmoxibustion on ulcerative colitis and itsinfluence on the colonic mucosal morphology.METHODS Forty-six patients with ulcerativecolitis were randomly divided into themoxibustion with herbal medicine underneathgroup and the western medicine group.Thirtypatients were treated with the abovemoxibustion and 16 patients with Salicylayefapyridine(SASP).The colonic mucosa of 13patients in the moxibustion group was observedby colonoscopy before and after the treatment.Mucin was also analyzed by H.E and AB-PASstaining.RESULTS Seventeen patients were clinicallycured,12 were improved and 1 unchanged in themoxibustion group.In the control group,5patients were clinically cured,7 improved and 4unchanged.Thirteen patients with active UCwere taken as the subjects for histopathologicanalysis in this study.The colonic mucosallesions were remarkably improved and thecharacteristic of the mucin also changed.Inmost sections,the chronic inflammation ofmucosa was geatly ameliorated(P<0.01).Theinflammatory cell infiltratation much decreased and neutrophils,disapeared in most sections(P<0.001).The goblet cells significantlyincreased(P<0.001);crypt paracrypt abscessor mucosal ulceration was seen(P<0.001).CONCLUSION The rate of cure of ulcerative colitis by moxibustion with herbal medicine beneath is superior to that by SASP. This sort of moxibustion can effectively improve the colonic mucosal lesions and restore the proportion of mucoprotein to near normal. | Huan Gan Wu Li Bin Zhou Da Ren Shi Shi Min Liu Hui Rong Liu Bi Meng Zhang Han Ping Chen Lin Shan Zhang | 2000 | World Journal of Gastroenterology2000，6，6： | 28 |
| 2 | Three-dimensional morphometric analysis for hepatectomy of centrally located hepatocellular carcinoma:A pilot study显示文摘AIM: To describe a three-dimensional model(3DM) to accurately reconstruct anatomic relationships of centrally located hepatocellular carcinomas(HCCs).METHODS: From March 2013 to July 2014, reconstructions and visual simulations of centrally located HCCs were performed in 39 patients using a 3D subject-based computed tomography(CT) model with customdeveloped software. CT images were used for the 3D reconstruction of Couinaud's pedicles and hepatic veins, and the calculation of corresponding tumor territories and hepatic segments was performed using Yorktal DMIT software. The respective volume, surgical margin, and simulated virtual resection of tumors were also estimated by this model preoperatively. All patients were treated surgically and the results were retrospectively assessed. Clinical characteristics, imaging data, procedure variables, pathologic features, and postoperative data were recorded and compared to determine the reliability of the model.RESULTS: 3D reconstruction allowed stereoscopic identification of the spatial relationships between physiologic and pathologic structures, and offered quantifiable liver resection proposals based on individualized liver anatomy. The predicted values were consistent with the actual values for tumor mass volume(82.4 ± 109.1 m L vs 84.1 ± 108.9 m L, P = 0.910), surgical margin(10.1 ± 6.2 mm vs 9.1 ± 5.9 mm, P = 0.488), and maximum tumor diameter(4.61 ± 2.16 cm vs 4.53 ± 2.14 cm, P = 0.871). In addition,the number and extent of portal venous ramifications, as well as their relation to hepatic veins, were visualized. Preoperative planning based on simulated resection facilitated complete resection of large tumors located in the confluence of major vessels. And most of the predicted data were correlated with intraoperative findings.CONCLUSION: This 3DM provides quantitative morphometry of tumor masses and a stereo-relationship with adjacent structures, thus providing a promising technique for the management of centrally located HCCs. | Fei Tian Jian-Xiong Wu Wei-Qi Rong Li-Ming Wang Fan Wu Wei-Bo Yu Song-Lin An Fa-Qiang Liu Li Feng Chao Bi Yun-He Liu | 2015 | World Journal of Gastroenterology2015，21，15： | 21 |
| 3 | Methylation status of c-fms oncogene in HCC and its relationship with clinical pathology显示文摘INTRODUCTIONThe mechanism that DNA hypomethylation leads toactivation of oncogene and occurrence of malignantneoplasm is being increasingly recognized byresearchers. Normal DNA methylation playsimportant role in stabilizing the phenotype of cell.DNA methylation status reduction and/or patternalteration are related to activation and abnormallyhigh expression of some oncogenes and cellularmalignancy[1-6]. c-fms oncogene encodes for colonystimulating factor 1 receptor (CSF-1R)[7], c-fms/CSF-1R was highly expressed in hepatocellularcarcinoma (HCC) tissue, but the mechanismremained obscure[8,9]. | Jun Cui Dong Hua Yang Xiang Jun Bi Zi Rong Fan Department of Gastroenterology, Zhujiang Hospital, The First Military Medical University, Guangzhou 510282, Guangdong Province, China | 2001 | World Journal of Gastroenterology2001，7，1： | 16 |
| 4 | Nearfield acoustic holography based on the equivalent source method显示文摘On the basis of the nearfield acoustic holography (NAH) based on the distributed source boundary point method (DSBPM), a novel NAH based on the equivalent source method (ESM) is proposed. The theoretical model of the proposed method is established at first. And then, the error sensitivity and the reconstruction problems of a multi-source acoustic field and a semi-free acoustic field are analyzed, and the corresponding treatment methods are proposed. Subsequently, an experiment on a speaker is investigated to validate the feasibility and correctness of the method. In the method, no discretization is needed on the boundary of the vibrating body. The acoustic field is predicted directly by a set of weighted equivalent sources located inside the vibrating body. Therefore, the variable interpolation, the treatments of singular integrals and non-uniqueness of solutions in the characteristic wave number are avoided. Additionally, the method is adapted to arbitrary-shaped source, so it is really a meshless method. Furthermore, there are such merits as the simple principle, the high calculation efficiency and precision. It is valuabe for the NAH to be applied in the practical engineering field. | BI Chuanxing CHEN Xinzhao CHEN Jian ZHOU Rong | 2005 | Science China(Technological Sciences)2005，48，3： | 11 |
| 5 | Blood Pressure Associated with Arsenic Methylation and Arsenic Metabolism Caused by Chronic Exposure to Arsenic in Tube Well Water显示文摘Objective The effects of arsenic exposure from drinking water, arsenic metabolism, and arsenic methylation on blood pressure(BP) were observed in this study. Methods The BP and arsenic species of 560 participants were determined. Logistic regression analysis was applied to estimate the odds ratios of BP associated with arsenic metabolites and arsenic methylation capability. Results BP was positively associated with cumulative arsenic exposure(CAE). Subjects with abnormal diastolic blood pressure(DBP), systolic blood pressure(SBP), and pulse pressure(PP) usually had higher urinary i As(inorganic arsenic), MMA(monomethylated arsenic), DMA(dimethylated arsenic), and TAs(total arsenic) than subjects with normal DBP, SBP, and PP. The i As%, MMA%, and DMA% differed slightly between subjects with abnormal BP and those with normal BP. The PMI and SMI were slightly higher in subjects with abnormal PP than in those with normal PP. Conclusion Our findings suggest that higher CAE may elevate BP. Males may have a higher risk of abnormal DBP, whereas females have a higher risk of abnormal SBP and PP. Higher urinary i As may increase the risk of abnormal BP. Lower PMI may elevate the BP. However, higher SMI may increase the DBP and SBP, and lower SMI may elevate the PP. | WEI Bing Gan YE Bi Xiong YU Jiang Ping YANG Lin Sheng LI Hai Rong XIA Ya Juan WU Ke Gong | 2017 | Biomedical and Environmental Sciences2017，30，5： | 9 |
| 6 | RECONSTRUCTION STABILITY OF NEARFIELD ACOUSTIC HOLOGRAPHY显示文摘The distributed source boundary point method (DSBPM) is used as the spatial transform algorithm for realizing nearfield acoustic holography (NAH), the sensitivity of the reconstructed solution to the measurement errors is analyzed, and the regularization method is proposed to stabilize the reconstruction process, control the influence of the measurement errors and get a better approximate solution. An oscillating sphere is investigated as a numerical example, the influence of the measurement errors on the reconstruction solution is demonstrated, and the feasibility and validity of the regularization method are validated. | Bi Chuanxing Chen Xinzhao Zhou Rong Chen Jian | 2005 | Chinese Journal of Mechanical Engineering2005，18，4： | 7 |
| 7 | Correlation of karst agricultural geo-environment with non-karst agricultural geo-environment with respect to nutritive elements in Guizhou显示文摘The karst area accounts for 61.9% of the total area in Guizhou Province, which gives rise to a fragile environment and backward economy. Comparative studies on the element contents of rock and soil and agriculture production in both carbonate area and non-carbonate area have been made to establish factors leading to low output and poor quality of agricultural products in the karst area. The result shows that there is an apparent lack of nutrient elements in carbonate rocks. The trace element contents of carbonate rocks are only 3532.27×10-6, but those of non-carbonate rocks are 10894.21×10-6. The available element contents in culti-vated soil delivered from carbonate rocks are merely 101.4×10-6, but those from non-carbonate rocks are 326.05×10-6. The available element contents and total element contents in cultivated soil delivered from non-carbonate rocks are 3 times higher than those from carbonate rocks. Besides, high-quality agricultural products such as rice, potato and tea are mainly produced in the non-carbonate area. It is indicated that the low output and quality of agricultural products are caused by the above-mentioned low trace element contents and poor agricultural environment. Therefore, a new method of mineral nutrients compensation has been put forward, which is very effective to raise the load-bearing capacity of agricultural environment, agricultural output and quality of agricultural products. | CHEN Rong BI Kun | 2011 | Chinese Journal Of Geochemistry2011，30，4： | 7 |
| 8 | A Novel Adaptive Cooperative Location Algorithm for Wireless Sensor Networks显示文摘To overcome the disadvantages of the location algorithm based on received signal strength indication(RSSI) in the existing wireless sensor networks(WSNs),a novel adaptive cooperative location algorithm is proposed.To tolerate some minor errors in the information of node position,a reference anchor node is employed.On the other hand,Dixon method is used to remove the outliers of RSSI,the standard deviation threshold of RSSI and the learning model are put forward to reduce the ranging error of RSSI and improve the positioning precision effectively.Simulations are run to evaluate the performance of the algorithm.The results show that the proposed algorithm offers more precise location and better stability and robustness. | Wen-Jiang Feng Xiao-Wei Bi Rong Jiang College of Communication Engineering,Chongqing University,Chongqing 400044,China | 2012 | International Journal of Automation and computing2012，9，5： | 4 |
| 9 | Biodistribution and Toxicity Assessment of Superparamagnetic Iron Oxide Nanoparticles In Vitro and In Vivo显示文摘Biodistribution and toxicity assessment are critical for safe clinical use of newly developed medicines.Superparamagnetic iron oxide nanoparticles (SPION)are effective carriers for targeted drug delivery.This study aimed to examine the toxicity and biodistribution of SPION coated with polyethylenimine (PEI)(SPION-PEI)designed for small interfering RNA (siRNA) delivery both in vitro and in vivo.SPION-PEI/siRNA complexes were prepared at different weight ratios.Cytotoxic effects of SPION-PEI/siRNA on HSC-T6 cell viability were determined by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT).Rats were divided into three groups:a control group,a normal-saline group and a SPION-PEI/siRNA group.After a single intravenous injection,in vivo nanoparticle biodistribution and accumulation were evaluated by Prussian blue staining in the heart,liver,spleen,lung and kidney 8 h,24 h,and 7 days after the injection.Their distribution was histologically studied at the three time points by measuring ironpositive areas (μm2)in organ sections stained with Prussian blue.The same organs were analyzed by H&E staining for any possible histopathological changes.Furthermore,biochemical indexes such as alanine amino transaminase (ALT),aspartate transaminase (AST),blood urea nitrogen (BUN)and creatinine (CREA)were also assessed at all experimental time points.Electrophoresis exhibited that the SPION-PEI could retard siRNA altogether at weight ratios above 4.MTT assay showed that SPION-PEI loaded with siRNA had low cytotoxicity.In vivo study revealed that the liver and spleen were the major sites of SPION-PEI/siRNA deposition.The iron content was significantly increased in the liver and spleen,peaking 24 h after intravenous injection and then declining gradually.No evidence was found of irreversible histopathological damage to any of the organs tested.These results suggested that most SPION-PEI/siRNA complexes were distributed in the liver and spleen,which might be the target organs of SPION-PEI/siRNA complexes.SPION- PEI/siRNA may serve as in vivo carrier for biomedical medicines. | Qin YU Xiao-qin XIONG Lei ZHAO Ting-ting XU Hao BI Rong FU Qian-hua WANG | 2018 | Current Medical Science2018，38，6： | 3 |
| 10 | Landweber iterative regularization for nearfield acoustic holography显示文摘On the basis of the distributed source boundary point method (DSBPM)-based nearfield acoustic holography (NAH), Landweber iterative regularization method is proposed to stabilize the NAH reconstruction process, control the influence of measurement errors on the reconstructed results and ensure the validity of the reconstructed results. And a new method, the auxiliary surface method, is pro- posed to determine the optimal iterative number for optimizing the regularization effect. Here, the optimal number is determined by minimizing the relative error between the calculated pressure on the auxiliary surface corresponding to each iterative number and the measured pressure. An experiment on a speaker is investigated to demonstrate the high sensitivity of the reconstructed results to measurement errors and to validate the chosen method of the optimal iterative number and the Landweber iterative regularization method for controlling the influence of measurement errors on the reconstructed results. | BI Chuanxing CHEN Xinzhao ZHOU Rong CHEN Jian | 2006 | Chinese Science Bulletin2006，51，11： | 3 |
| 11 | Bioactivity, pharmacokinetics, and immunogenicity assays in preclinical and clinical trials for recombinant human endostatin显示文摘瞄准:决定在里面 vitro 并且在 recombinant 人 endostatin (rhEndostatin ) 并且到的 vivo 简历活动在恒河猴和病人分析它的 pharmacokinetics 和 immunogenicity。方法:rhEndostatin 的物理化学特征根据中华人民共和国的药典被检测(2005 编辑,部分 III ) 。它的在里面 vitro 并且在 vivo,简历活动是经由人的脐的静脉 endothelial 房间上的增长抑制的 assayed,他们忍受肿瘤的老鼠上的禁止的效果当模特儿。在猴子和病人的 rhEndostatin 的浆液集中被一个酶免疫分析方法决定。结果:相应在从数方法的房间获得的 rhEndostatin 的 vitro 活动特定,3-( 4,5-dimethylthiazol-2-yl ) -2,5-diphenyltetrazolium 溴化物( MTT )试金,并且喂奶分别地,脱氢酶试金是 6.4 ×1 0 7, 6.7 ×1 0 7,和 3.8 ×1 0 8 U/mg ,并且在里面 vivo antitumoral 力量是 4.04 ×1 0 7 U/mg 。在恒河猴,在所有 pharmacokinetic 参数没有性差别。浆液 anti-rhEndostatin 免疫球蛋白(Ig ) G 抗体快速被产生在以后静脉内(iv ) 管理并且当治疗被停止时,很快减少了。在阶段我临床的试用,在 rhEndostatin 的 pharmacokinetics 的线性被区域的剂量相称的增加在曲线和最大的浆液集中下面显示。浆液 rhEndostatin 以 272.44 ± 9 的一个稳定的状态与平均集中在连续管理的 7 d 以后到达了不变的水平 1.98 ng/mL。对 rhEndostatin 的既不 IgG 也不 IgM 抗体在病人被观察。结论:RhEndostatin 在老鼠在 HUVEC,和重要 antitumoral 活动上展出了明确的增长抑制效果。到 rhEndostatin 的恒河猴的免疫反应是普通的,并且 rhEndostatin 不在这试用在病人显示出 immunogenicity。结果为进一步临床的试用提供一个基础。 | Bi HU Hao-wen ZHU Li-ping ZHU Chen LI Zhi-gang RONG Jia-ming XU Zhi-wei WU Jian-jun WANG Gen-xing XU | 2008 | Acta Pharmacologica Sinica2008，29，11： | 3 |
| 12 | Dog-transmitted Rabies in Beijing, China显示文摘Rabies remains a continuous threat to public health in Beijing.In this study,a total of 224 brain tissues were collected from suspected infected stray dogs within Beijing between January 2015 and December 2016.Among them,total of 67 samples were diagnosed positive for rabies.In the phylogenetic analysis,rabies in Beijing is currently a relatively independent public health issue originating from local rabid dogs apart from the imported cases from elsewhere in the country.Because vaccination of unregistered dogs against rabies is still neglected in Beijing and other regions of China,national and local authorities should play central roles in all related aspects,such as development of policies,engagement of stakeholders for public and professional education,entire vaccination process,and animal management. | ZHANG Jing Yuan ZHANG Bi ZHANG Shou Feng ZHANG Fei LI Nan LIU Ye HU Rong Liang | 2017 | Biomedical and Environmental Sciences2017，30，7： | 3 |
| 13 | A novel microRNA targeting HDAC5 regulates osteoblast differentiation in mice and contributes to primary osteoporosis in humans显示文摘 | Li Hui Xie Hui Liu Wei Hu Rong Huang Bi Tan Yan-Fei Liao Er-Yuan Xu Kang Sheng Zhi-Feng Zhou Hou-De Wu Xian-Ping Luo Xiang-Hang | 2009 | Journal of Clinical Investigation2009，，12： | 3 |
| 14 | A New Pyrone Derivative from Fungus Cephalosporium sp. AL031显示文摘A novel pyrone derivative was isolated from the ethyl acetate extract of a culture broth of a strain of the fungus Cephalosporium sp. AL031. Its structure was characterized as 7-hydroxy-9-methoxyl-10-methyl-2H, 4aH, 6H, 10bH-pyrano[5, 6-c][2]benzopyran-2, 6-dione by spectroscopic analysis including IR, MS, 1D and 2D NMR spectra. | Yun Mei BI Xu Bin BI Qian Rong ZHAO Fang A Ye Gao CHEN | 2006 | Chinese Chemical Letters2006，17，3： | 2 |
| 15 | Cancer-testis Antigen OY-TES-1 Expression and Immunogenicity in Hepatocellular Carcinoma显示文摘Summary:Cancer testis(CT)antigens have received particular attention in cancer immunotherapy.OY-TES-1 is a member of CT antigens.This study was to evaluate OY-TES-1 expression and immunogenicity in hepatocelluar carcinoma(HCC).OY-TES-1 mRNA expression was detected in 56 HCC tissues and 5 normal liver tissues by reverse transcriptase PCR(RT-PCR).Of the 56 cases of HCC tissues tested,37 cases had tumor and matched adjacent non-cancer tissues and were subjected to both RT-PCR and quantitative real-time PCR.OY-TES-1 protein was subsequently observed on a panel of tissue microarrays.Sera from patients were tested for OY-TES-1 antibody by ELISA.To identify OY-TES-1 capable of inducing cellular immune response,OY-TES-1 protein was used to sensitize dentritic cells and the cytotoxicity effect was measured in vitro.The results showed that OY-TES-1 mRNA was highly expressed in 41 of the 56(73.21%)HCC tissues,whereas none in 5 normal liver tissues.OY-TES-1 mRNA was frequently expressed not only in HCC tissues(72.97%,27/37),but also in paired adjacent non-cancer tissues(64.86%,24/37).But the mean expression level of OY-TES-1 mRNA in HCC tissues was significantly higher than that in adjacent non-cancer tissues(0.76854 vs.0.09834,P=0.021).Immunohistochemistry showed that OY-TES-1 protein expression was detected in 6 of the 49 cases of HCC tissues,and absent in 9 cases of normal liver and 6 cases of cirrhosis tissues.Seropositivity was detected in 10 of the 45 HCC patients,but not detected in 17 cirrhosis patients and 76 healthy donors.The specific cytotoxic T cells elicited by OY-TES-1 could kill HLA-A2^+HCC cell line which expressed OY-TES-1.The target lysis was mainly HLA class I-dependent and could be blocked by antibodies against monomorphic HLA class I but not HLA class II molecule.In summary,OY-TES-1 expression is upregulated in HCC tissues and can be recognized by humoral and cellular responses,which suggests that OY-TES-1 is an attractive target for tumor immunotherapy in HCC. | Bin LUO Xiang YUN Jing LI Rong FAN Wen-wen GUO Chang LIU Yong-da LIN Ying-ying GE Xia ZENG Shui-qing BI Wei-xia NONG Qing-mei ZHANG Xiao-xun XIE | 2020 | Current Medical Science2020，40，4： | 2 |
| 16 | Phase Evolution and Thermal Expansion Behavior of aγ′Precipitated Ni-Based Superalloy by Synchrotron X-Ray Diffraction显示文摘The phase evolution and thermal expansion behavior in superalloy during heating play an essential role in controlling the size and distribution of precipitates,as well as optimizing thermomechanical properties.Synchrotron X-ray diffraction is able to go through the interior of sample and can be carried out with in situ environment,and thus,it can obtain more statistics information in real time comparing with traditional methods,such as electron and optical microscopies.In this study,in situ heating synchrotron X-ray diffraction was carried out to study the phase evolution in a typicalγ′phase precipitation strengthened Ni-based superalloy,Waspaloy,from 29 to 1050°C.Theγ′,γ,M_(23)C_(6)and M C phases,including their lattice parameters,misfits,dissolution behavior and thermal expansion coefficients,were mainly investigated.Theγ′phase and M_(23)C_(6)carbides appeared obvious dissolution during heating and re-precipitated when the temperature dropped to room temperature.Combining with the microscopy results,we can indicate that the dissolution of M_(23)C_(6)leads to the growth of grain andγ′phase cannot be completely dissolved for the short holding time above the solution temperature.Besides,the coefficients of thermal expansions of all the phases are calculated and fitted as polynomials. | Zhiran Yan Qing Tan Hua Huang Hailong Qin Yi Rong Zhongnan Bi Runguang Li Yang Ren Yandong Wang | 2022 | Acta Metallurgica Sinica(English Letters)2022，35，1： | 2 |
| 17 | Long-term effects of high lipid and high energy diet on serum lipid, brain fatty acid composition, and memory and learning ability in mice显示文摘 | Huanling Yu Yanxia Bi Weiwei Ma Lingling He Linhong Yuan Jinfang Feng Rong Xiao | 2009 | International Journal of Developmental Neuroscience2009，，3： | 1 |
| 18 | In situ detection of EpsteinBarr virus in gastric carcinoma tissuein China highrisk area显示文摘 | WAN Rong, GAO Mei Qin, GAO Ling Yun, CHEN Bi Feng and CAI Qian Kun | 1999 | World Journal of Gastroenterology1999，5，6： | 1 |
| 19 | A novel indirect wollastonite carbonation route for CO2 sequestration 显示文摘 | Zhang Jianshu Zhang Rong Hans G Bi Jicheng | 2010 | Chemical Engineering & Technology2010，33，7： | 1 |
| 20 | Tranexamic acid reduces postoperative blood loss of degenerative lumbar instability with stenosis in posterior approach lumbar surgery: a randomized controlled trial显示文摘 | Qi Wang Jun Liu Rong Fan Yu Chen Hailong Yu Yan Bi Zhengzhe Hua Meihui Piao Mingming Guo Weijian Ren Liangbi Xiang | 2013 | European Spine Journal2013，，9： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员