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| 1 | Variability of cell proliferation in the proximal and distal colon of normal rats and rats with dimethylhydrazine induced carcinogenesis显示文摘AIM:To investigate the patterns of cell proliferation in proximal and distal colons in normal rats and rats with1,2-dimethylhydrazine(DMH)induced carcinogenesis using the thymidine analogue bromodeoxyuridine.METHODS:Colonic crypt cell proliferation was immunohistochemically detected using the anti-bromodeoxyuridine Bu20a monoclonal antibody.RESULTS:Marked regional differences were found in both groups.Total labelling index(LI)and proliferative zone size in both normal(8.65±0.34vs7.2±0.45,27.74±1.07vs16.75±1.45)andDMH groups(13.13±0.46vs11.55±0.45,39.60±1.32vs35.52±1.58)were significantly higher in distal than in proximal colon(P<0.05).although the number of cells per proxmal crypt was greater(31.45±0.20vs34.45±0.39,42.68±0.53vs49.09±0.65,P<0.001).Crypt length,total LT and proliferative zone size all increased in both proximal and distal regions of DMH rats compared to normal controls(P<0.0001).In DMH-treated rat colon a shift of labelled cells to higher crypt cell positions was demonstrated distally whist a bi-directional shift was evident proximally(P<0.05).CONCLUSION:Our results show that changes in cell proliferation patterns,as assessed by bromodeoxyuridine uptake,can act as a reliable intermediate marker of colonic cancer formation.Observed differences between proliferation patterns in distal and proximal colon may be associated with the higher incidence of tumors in t he distal colon. | Kate E Williamson Brian J Rowlands | 2002 | World Journal of Gastroenterology2002，8，5： | 12 |
| 2 | In Vivo analysis of growth hormone receptor signaling domains and their associated transcripts显示文摘 | Jennifer E Rowland Aginieszka M | 2005 | Molecullar and Cellular Biology2005，，2： | 1 |
| 3 | Wolff-Parkinson- White syndrome: atrial fibrillation as the presenting ar- rhythmia显示文摘 | Robinson K Rowland E Krikler DM | 1988 | Br Heart J1988，59，5： | 1 |
| 4 | Continuous full field representation and differentiation of three:dimensional experimental vector data显示文摘 | Feng Z Rowlands R E | 1987 | Computers and Structures1987，26，6： | 1 |
| 5 | Solid-phase extraction fractionation to extend the characterization of naphthenic acids in crude oil by electro spray ionization fourier transform ion cyclotron resonance mass spectrometry显示文摘 | Rowland Steven M Robbins Winston K Corilo Yuri E | 2014 | Energy and Fuels2014，28，8： | 1 |
| 6 | Australia's search for petroleum: patterns of discovery显示文摘 | Bradshaw M T Foster C B Fellows M E & Rowland D C | 1999 | Oil & Gas Journal1999，97，23： | 1 |
| 7 | The structure of foot - and -mouth disease virus显示文摘 | FRY E E STUART D I ROWLANDS D J | 2005 | Curt Top Microbiol Immuno2005，288，： | 1 |
| 8 | cDNA - AFLP reveals a striking overlap in race - specific resistance and wound response gene expression profiles 显示文摘 | Durrant W E Rowland O Piedras P | 2000 | Plant Cell2000，12，： | 1 |
| 9 | Vege- tation diversity in an interconnected ephemeral ripari- an system of north central Arizona,USA显示文摘 | Zimmerman J C de Wald L E Rowlands P G | 1999 | Biolog- ical Conservation1999，90，： | 1 |
| 10 | Neutralizing epitopes of type O foot-and-mouth disease virus: 1 Identification and charaterization of three functionally independent conformational sites 显示文摘 | Barnett P V Ouldridge E J Rowlands D J | 1989 | J Gen Virol1989，70，： | 1 |
| 11 | Tissue rupture and bubble formation during radiofrequency catheter ablation : 'Echoes of a Pop' 显示文摘 | Juneja R O'Callaghan P Rowland E | 2001 | Circulation2001，103，9： | 1 |
| 12 | Wolff-Parkinson-White syndrome:atrialfibrillation as the presenting arrhythmia 显示文摘 | 3,Robinson K Rowland E Krikler DM | 1988 | Br Heart J1988，59，： | 1 |
| 13 | Antibody to capsular polysaccharides of streptococcus pneumoniae:prevalence,persistence,and response to revaccination显示文摘 | MUSHER D M GROOVER J E ROWLAND J M | 1993 | Clin Infect Dis1993，17，： | 1 |
| 14 | Origin of the threshing character in hexaploid wheat显示文摘 | Kerber R E Rowland G G | 1974 | Can J Genet Cytol1974，16，： | 1 |
| 15 | New A- nalysis of Lunar Prospector Radio Tracking Data Brings the Nearside Gravity Field of the Moon with an Unprecedented Resolution显示文摘 | Han S C Mazarico E Rowlands D | 2011 | Icarus2011，215，2： | 1 |
| 16 | Skeletal and ten- don lesions ofmale broiler -breeders reared on ele- vated slats显示文摘 | Hill J E Rowland C N Glisson J R | 1988 | Avian Diseases1988，32，3： | 1 |
| 17 | Metabolism of isoflavones and lignans by the gut microflora:a study in germ-free and human flora associated rats显示文摘 | BOWEY E ADLERCREUTZ H ROWLAND I | 2003 | Food Chem Toxicol2003，41，5： | 1 |
| 18 | Beta2 adrenergic receptors mediate important electrophysiological effects in human ventricular myocardium显示文摘 | Lowe MD Rowland E Brown M J | 2001 | Heart2001，86，1： | 1 |
| 19 | Use of Blueberry to Study Genetic Control of Chilling Requirement and Cold Hardiness in Woody Perennials显示文摘 | Rowland L J Ogden E L Arora R | 1999 | Hort Sci1999，34，7： | 1 |
| 20 | Evaluation of Midwinter Cold Hardiness among 25 Rabbiteye blueberry c ultivar显示文摘 | Ehlenfeldt M K Ogden E L Rowland L J | 2006 | Hort Sci2006，41，3： | 1 |
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