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| 1 | Colorectal cancer and dysplasia in inflammatory bowel disease显示文摘Both ulcerative colitis and Crohn’s disease carry an increased risk of developing colorectal cancer. Established risk factors for cancer among patients with inflammatory bowel disease (IBD) include the younger age at diagnosis, greater extent and duration of disease, increased severity of inflammation, family history of colorectal cancer and coexisting primary sclerosing cholangitis. Recent evidence suggests that current medical therapies and surgical techniques for inflammatory bowel disease may be reducing the incidence of this complication. Nonetheless heightened vigilance and a careful, comprehensive approach to prevent or minimize the complications of invasive cancer are warranted in this unique cohort of patients. Current guidelines for the prevention and early detection of cancer in this high risk population are grounded in the concept of an inflammation-dysplasia- carcinoma sequence. A thorough understanding of the definition and natural history of dysplasia in IBD, as well as the challenges associated with detection and interpretation of dysplasia are fundamental to developing an effective strategy for surveillance and prevention, and understanding the limitations of the current approach to prevention. This article reviews the current consensus guidelines for screening and surveillance of cancer in IBD, as well as presenting the evidence and rationale for chemoprevention of cancer and a discussion of emerging technologies for the detection of dysplasia. | Timothy L Zisman David T Rubin | 2008 | World Journal of Gastroenterology2008，14，17： | 13 |
| 2 | Risk of post-operative complications associated with anti-TNF therapy in inflammatory bowel disease显示文摘There have been increasing concerns regarding the safety of perioperative anti-tumour necrosis factor (anti-TNF) α agents. We performed a literature review to evaluate the post-operative complications associated with perioperative anti-TNF use in patients with inflammatory bowel disease. A comprehensive review was performed with a literature search utilizing Pub Med, Cochrane, OVID and EMBASE databases according to published guidelines. To date, there are only data for infliximab. There are three published studies which have assessed post-operative complications with perioperative infliximab use in patients with Crohn' s disease (CD), four studies in ulcerative colitis (UC) patients, and one study on both CD and UC patients. Two out of the three studies in CD patients showed no increased post-operative complications associated with perioperative infliximab. Two out of four studies in UC patients also did not show an increase in post-operative complications, and the combined study with CD and UC patients did not show an increased risk as well. Studyresults could not be combined secondary to significant differences in study designs, patient population and definition of their endpoints. There appears to be a risk of post-operative complications associated with TNF therapy in some patients. Based on these data, careful patient selection and prospective data collection should be performed. | Tauseef Ali Laura Yun David T Rubin | 2012 | World Journal of Gastroenterology2012，18，3： | 2 |
| 3 | Sensitivity of Phytophthora infestans to Mandipropamid and the Effect of Enforeed Selection Pressure in the Field显示文摘 | COHEN Y RUBIN E HADAD T | 2007 | Plant Pathology2007，56，5： | 1 |
| 4 | Human KGF is FGF - related with properties of a paracrine effector of epithelial cell growth显示文摘 | Finch PW Rubin JS Mild T | 1998 | Science1998，245，： | 1 |
| 5 | Organo-clay Formulations of the Hydrophobic Herbicide Norflurazon Yield Reduced Leaching 显示文摘 | UNDABEYTIA T NIR S RUBIN B | 2000 | J Agric Food Chem2000，48，： | 1 |
| 6 | Elasto-plastic coupled temperature-displacement f'mite element analysis of two-dimensional rolling-sliding contact with a translating heat source 显示文摘 | Kulkami S M Rubin C A Hahn G T | 1991 | Journal of Tribology1991，113，1： | 1 |
| 7 | Theory of the Three-photon Entangled State显示文摘 | KELLER T E RUBIN M H SHIH Y | 1998 | Phys Rev A1998，57，： | 1 |
| 8 | Fracture Risk Prediction Using Phalangeal Bone Mineral Density or FRAX-A Danish Cohort Study on Men and Women 显示文摘 | Friis-Holmberg T Rubin KH Brixen K | 2014 | Clin Densitom2014，17，1： | 1 |
| 9 | An engineering-economic mod- el of pipeline transport of COs with application to carbon capture and storage显示文摘 | MCCOY S T RUBIN E S | 2008 | International Journal of Greenhouse Gas Control2008，2，2： | 1 |
| 10 | Kit extracellular and kinase domain mutation in gastrointestinal stromal tumors显示文摘 | Lux M L Rubin B P Biase T L | 2000 | Am J Pathol2000，156，3： | 1 |
| 11 | Formation of an effective opening within the fullerene core of C60 by an unusual reaction sequence 显示文摘 | Schick G Jarrosson T Rubin Y | 1999 | Angew Chem Int Ed1999，38，16： | 1 |
| 12 | Successful resuscitation after ropivacaine-induced ventricular fibrillation显示文摘 | Klein SM Pierce T Rubin Y | 2003 | Anesth Analg2003，97，： | 1 |
| 13 | Members of the LBD family of transcription factors repress anthocyanin synthesis and affect additional nitrogen responses in Arabidopsis显示文摘 | RUBIN G TOHGE T MATSUDA F | 2009 | The Plant Cell2009，21，11： | 1 |
| 14 | Antimicrobial residues in animal waste and water resources proximal to large-scale swine and poultry feeding operations显示文摘 | Campagnolo E R Johnson K R Karpati A Rubin C S Kolpin D W Meyer M T Esteban J E Currier R W Smith K Thu K M McGeehin M | | 0，，： | 1 |
| 15 | Elastoplastic finite element analysis of repeated three-di- mensional elliptical rolling contact with rail wheel prop- erties 显示文摘 | KULKARMI S M HAHN G T RUBIN C A | 1991 | ASME Journal of Tribology1991，113，3： | 1 |
| 16 | Chronic thromboembolic pulmonary hypertension显示文摘 | Williamson T L Kim N H Rubin L J | 2002 | Prog Cardiovasc Dis2002，45，： | 1 |
| 17 | Breakups before marriage: The end of 103 affairs 显示文摘 | Hill C T Rubin Z Peplau L A | 1976 | Journal of Social Issues1976，32，1： | 1 |
| 18 | Longterm complications of congenital es ophageal atresia and/or tracheoesophageal fistula显示文摘 | Rubin S | 2004 | Chest2004，126，3： | 1 |
| 19 | Twinkling artifact on color Doppler sonography: Dependence on machine parameters and underlying cause显示文摘 | Kamaya A Tuthill T Rubin J M | 2003 | AJR2003，180，1： | 1 |
| 20 | Long-term complications of congenital esophageal atresia and/or tracheoesophageal fistula显示文摘 | Kovesi T Rubin S | 2004 | Chest2004，126，3： | 1 |
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