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| 1 | The multiplayer perceptron as an approximation to a Bayes optimal discriminat function显示文摘 | Ruck D W Rogers S K Kabrisky M | 1990 | IEEE Transactions on Neural Networks1990，1，4： | 1 |
| 2 | Parturition at term:parallel increases in interleukin-8 and proteinase concentrations and neutrophil count in the lower uterine segment显示文摘 | Winkler M Fischer D C Ruck P | 1999 | Hum Reprod1999，14，： | 1 |
| 3 | Evidence from the surface morphology for nonlinear growth of epitaxial GaAs films显示文摘 | Ballestad A Ruck B J Adamcyk M | 2001 | Phys Rev Lett2001，86，： | 1 |
| 4 | Immune status,psychoancial distress and reduced quality of life in infertile patients with endometriosis显示文摘 | Siedcntopf F Tariverdian N Rucke M | 2008 | Am J Reprod Immunol2008，60，5： | 1 |
| 5 | Compara- tive analysis of backpropagation and the extended Kal- man filter for training multilayer perceptrons 显示文摘 | Ruck D W Rogers S K Kabrisky M | 1992 | IEEE Transactions on Pattern Analysis and Machine In- telligence1992，14，6： | 1 |
| 6 | Localization and quanti- fication of adhesion molecule expression in the lower uterine segment during premature labor显示文摘 | Fischer DC Winkler M Ruck P | 2001 | J Perinat Med2001，29，6： | 1 |
| 7 | Early risk factors for miscarriage: A prospective cohort study in pregnant women 显示文摘 | Arck P C Rucke M Rose M | 2008 | Reprod Biomed Online2008，17，1： | 1 |
| 8 | Functional T lymphocytes infiltrate implanted polyvinyl alcohol foams during surgical wound closure therapy 显示文摘 | Gouttefangeas C Eberle M Ruck P | 2001 | Cli Exp Immunol2001，124，3： | 1 |
| 9 | Ultra-rapid detection of Chlamydia trachomatis by real-time PCR in the Light Cycler using SYBR green technology or 5'-nuclease probes显示文摘 | Eickhoff M Laue T Ruckes T | 2003 | Clin Lab2003，49，56： | 1 |
| 10 | Functional T lymphocytes infiltrate implanted polyvinyl alcohol foams during surgical wound closure therapy显示文摘 | Gouttefangeas C Eberle M Ruck P | 2001 | Clin Exp Immu-nol2001，124，3： | 1 |
| 11 | Green iodination of pyrazoles with iodine/hydrogen peroxide in water显示文摘 | Kim M N Ruck R T Zhao D | 2008 | Tetrahedron Letters2008，49，： | 1 |
| 12 | Functional T lymphocytes infiltrate implanted polyvinyl alcohol foams during surgical wound closure therapy显示文摘 | Gouttefangeas C Eberle M Ruck P | | 0，，03： | 1 |
| 13 | The next-generation sphingosine-1 receptor modulator BAF312(siponimod) improves cortical network functionality in focal autoimmune encephalomyelitis显示文摘Autoimmune diseases of the central nervous system(CNS) like multiple sclerosis(MS) are characterized by inflammation and demyelinated lesions in white and grey matter regions. While inflammation is present at all stages of MS, it is more pronounced in the relapsing forms of the disease, whereas progressive MS(PMS) shows significant neuroaxonal damage and grey and white matter atrophy. Hence, disease-modifying treatments beneficial in patients with relapsing MS have limited success in PMS. BAF312(siponimod) is a novel sphingosine-1-phosphate receptor modulator shown to delay progression in PMS. Besides reducing inflammation by sequestering lymphocytes in lymphoid tissues, BAF312 crosses the blood-brain barrier and binds its receptors on neurons, astrocytes and oligodendrocytes. To evaluate potential direct neuroprotective effects, BAF312 was systemically or locally administered in the CNS of experimental autoimmune encephalomyelitis mice with distinct grey-and white-matter lesions(focal experimental autoimmune encephalomyelitis using an osmotic mini-pump). Ex-vivo flow cytometry revealed that systemic but not local BAF312 administration lowered immune cell infiltration in animals with both grey and white matter lesions. Ex-vivo voltage-sensitive dye imaging of acute brain slices revealed an altered spatio-temporal pattern of activation in the lesioned cortex compared to controls in response to electrical stimulation of incoming white-matter fiber tracts. Here, BAF312 administration showed partial restore of cortical neuronal circuit function. The data suggest that BAF312 exerts a neuroprotective effect after crossing the blood-brain barrier independently of peripheral effects on immune cells. Experiments were carried out in accordance with German and EU animal protection law and approved by local authorities(Landesamt für Natur, Umwelt und Verbraucherschutz Nordrhein-Westfalen;87-51.04.2010.A331) on December 28, 2010. | Petra Hundehege Manuela Cerina Susann Eichler Christian Thomas Alexander M. Herrmann Kerstin Goel Thomas Müntefering Juncal Fernandez-Orth Stefanie Bock Venu Narayanan Thomas Budde Erwin-Josef Speckmann Heinz Wiendl Anna Schubart Tobias Ruck Sven G. Meuth | 2019 | Neural Regeneration Research2019，14，11： | 1 |
| 14 | A new approach to data evaluation in the non-target screening of organic trace substances in water analysis显示文摘 | MūLLER A SCHULZ W RUCK W K | 2011 | Chemosphere2011，85，8： | 1 |
| 15 | Functional T lymphocytes infiltrate implanted polyvintl alcohol foams during surgical wound closure therapy显示文摘 | Gorttefangeas C Eberle M Ruck P | 2001 | Clin Exp Immunol2001，124，： | 1 |
| 16 | Functional T lymphocytes infiltrate implanted polyvinyl alcohol foams during surgical wound closure therapy显示文摘 | Gouttefangeas C Eberle M Ruck P | | 0，，03： | 1 |
| 17 | Immunestatus,psychosocial distress and reduced quality of life ininfertile patients with endometriosis显示文摘 | Siedentop F Tariverdian N Rucke M | 2008 | Am J ReprodImmunol2008，60，5： | 1 |
| 18 | Immune status, psychosocial distress and reduced quality of life in infertile patients with endometriosis显示文摘 | Siedentopf F Tariverdian N Rucke M | 2008 | Am J Reprod Immunol2008，60，5： | 1 |
| 19 | Bank Competition and Credit Standards 显示文摘 | Ruckes M | 2004 | The Review of Financial Studies2004，17，4： | 1 |
| 20 | Object tracking through adaptive correlation显示文摘 | Steven K R Dennis W Ruck | 1994 | Optical Engineering1994，33，1： | 1 |
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