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| 1 | Engineering nanoparticles for targeting rheumatoid arthritis: Past, present, and future trends显示文摘风湿性关节炎(RA ) 是 synovial 关节发炎和软骨和骨头织物破坏描绘的长期的煽动性的疾病。尽管在那里存在为 RA 的一些处理策略,他们不完全安全、有效。因此,为明确地,目标 inflamed/swollen 连接的 RA 开发并且测试并且同时稀释另外的可能的损坏到健康纸巾新药是重要的。当为对待 RA 想象精确的药时,纳米技术能是一种好选择考虑。通过 nanoparticles 的使用,增加治疗学的 bioavailability 和 bioactivity 并且启用到损坏关节的选择指向是可能的。此处,用为 RA 的处理的 nanoparticles 的最近的研究,也就是与 liposomes,聚合 nanoparticles, dendrimers,和金属性的 nanoparticles,被考察了。这些治疗学的策略在由传统的药在那上改进处理显示出大诺言。这些研究的结果证实 nanoparticles 的使用的可行性主要由于他们的 biocompatibility,低毒性,控制版本,和选择的药交货到在动物 RA 模型的煽动的纸巾。因此,宣称在不久的将来,纳米技术将为象 RA 那样的人的疾病在先进治疗和病人特定的治疗起一个关键作用是可能的。 | Isabel Matos Oliveira Cristiana Goncalves Rui Lufs Reis Joaquim Miguel Oliveira | 2018 | Nano Research2018，11，9： | 11 |
| 2 | Clinical and pathological characterization of epstein-barr virus-associated gastric carcinomas in portugal显示文摘AIM To determine the prevalence of epstein-barr virus(eb V)-associated gastric carcinomas in the North Region of Portugal and to study its clinicopathological characteristics. METHODS We have performed a retrospective study including a total of 179 consecutive patients with gastric cancer(GC) submitted to gastrectomy during 2011 at the Portuguese Oncology Institute of Porto. Clinical and pathological data was collected from individual clinical records and inserted on a database with unique codification. Tumour tissues were collected from the institutional tumour bank. eb V was detected by in situ hybridization for the detection of eb V-encoded small RNAs(ebe Rs) and eb V latent proteins(LMP1 and LMP2 A) were detected by immunohistochemistry.RESULTS The analysis showed that eb V-associated gastric carcinomas(eb Va GC) represents 8.4%(15/179) of all GC cases, with a significant differential distribution among histological types(P < 0.001): 100%(3/3) of medullary carcinomas, 100%(1/1) of adenosquamous carcinoma, 8.7%(8/92) of tubular adenocarcinomas, 8.0%(2/25) of mixed carcinomas and 2%(1/51) in poorly cohesive carcinomas. The analysis revealed a higher predominance of eb Va GC in the upper third and middle(cardia, fundus and body) of the stomach(P = 0.041), a significant lower number of regional lymph nodes invasion(P = 0.025) and a tendency for better prognosis(P = 0.222). eb V latent protein expression revealed that all eb Va GC cases were LMP1-negative, nevertheless 6 cases(40%) expressed LPM2 A, which reveals that these cases show a distinct eb V-Latency profile(latency II-like).CONCLUSION eb Va GC represents 8.4% of all GC in the North Region of Portugal. The eb V-infected patients have specific clinic-pathological features that should be further explored to develop new strategies of management and treatment. | Joana Ribeiro Andreia Oliveira Mariana Malta Claudia Oliveira Fernanda Silva Ana Galaghar Luís Pedro Afonso Maria Cassiano Neves Rui Medeiros Pedro Pimentel-Nunes Hugo Sousa | 2017 | World Journal of Gastroenterology2017，23，40： | 9 |
| 3 | Adaptable hydrogel with reversible linkages for regenerative medicine:Dynamic mechanical microenvironment for cells显示文摘Hydrogels are three-dimensional platforms that serve as substitutes for native extracellular matrix.These materials are starting to play important roles in regenerative medicine because of their similarities to native matrix in water content and flexibility.It would be very advantagoues for researchers to be able to regulate cell behavior and fate with specific hydrogels that have tunable mechanical properties as biophysical cues.Recent developments in dynamic chemistry have yielded designs of adaptable hydrogels that mimic dynamic nature of extracellular matrix.The current review provides a comprehensive overview for adaptable hydrogel in regenerative medicine as follows.First,we outline strategies to design adaptable hydrogel network with reversible linkages according to previous findings in supramolecular chemistry and dynamic covalent chemistry.Next,we describe the mechanism of dynamic mechanical microenvironment influence cell behaviors and fate,including how stress relaxation influences on cell behavior and how mechanosignals regulate matrix remodeling.Finally,we highlight techniques such as bioprinting which utilize adaptable hydrogel in regenerative medicine.We conclude by discussing the limitations and challenges for adaptable hydrogel,and we present perspectives for future studies. | Zongrui Tong Lulu Jin Joaquim Miguel Oliveira Rui LReis Qi Zhong Zhengwei Mao Changyou Gao | 2021 | Bioactive Materials2021，6，5： | 8 |
| 4 | Functionally graded additive manufacturing to achieve functionality specifications of osteochondral scaffolds显示文摘 | Mario Monzon Chaozong Liu Sara Ajami Miguel Oliveira Ricardo Donate Viviana Ribeiro Rui L. Reis | 2018 | Bio-Design and Manufacturing2018，1，1： | 6 |
| 5 | Optimization of polyhydroxybutyrate production by mixed cultures submitted to aerobic synamic feeding conditions 显示文摘 | Luisa S Serafim Paulo C Lemos Rui Oliveira | 2004 | Biotechnology and Bioengineering2004，87，2： | 1 |
| 6 | Mitochondrial Preservation in Celsior Versus Histidine Buffer Solution During Cardiac Ischemia and Reperfusion显示文摘 | Marco G. Alves Paulo J. Oliveira Rui A. Carvalho | 2009 | Cardiovascular Toxicology2009，，4： | 1 |
| 7 | Contrasting impact of small dams on the macroinvertebrates of two Iberian mountain rivers显示文摘 | Rui Manuel Vitor Cortes Maria Teresa Ferreira Simone Varandas Oliveira Francisco Godinho | 1998 | Hydrobiologia1998，，1： | 1 |
| 8 | Simultaneous determination of ranitidine and metronidazole in human plasma using high performance liquid chromatography with diode array detection Journal of Pharmaceutical and Biomedical Analysis显示文摘 | Ticiano Gomes do Nascimento Eduardo de Jesus Oliveira and Rui Oliveira Mac (e) do | 2005 | Volume 37 Issue 4 1 April 20052005，，： | 1 |
| 9 | Efficiency and its determinants in Portuguese hotels inthe Algarve显示文摘 | Ricardo Oliveira Maria Isabel Pedro Rui Cunha Marques | 2013 | Tourism Management2013，36，： | 1 |
| 10 | Fatigue Strength Evaluation of Resin-Injected Bolted Connections Using Statistical Analysis显示文摘在对老旧的螺栓和铆接金属桥进行修补和加固时可以使用不同的方案。由于铆接链接技术目前并不常用,连接它需要特定的设备和熟练的工人。另一种解决方案是使用焊接。但是,老旧钢材的可焊性较差。螺栓是一种非常可行的替代解决方案,并且常用于修复旧金属桥。装配螺栓的解决方案成本高昂,另一种方法是使用树脂灌注式螺栓。带有预紧力的树脂灌注式老旧螺栓连接的受力性能已经用准静态和蠕变试验进行了研究,然而,关于这些连接节点的滑移和疲劳行为的文献很少。本文概述了几位研究者的实验项目,旨在评估单侧受剪和双侧受剪的树脂灌注式螺栓连接的疲劳行为。对有预紧力的标准螺栓和有预紧力的树脂灌注式螺栓的连接节点的实验数据进行比较分析,显示后者的疲劳强度较低。但欧洲规范3(EC3)对树脂灌注式螺栓和标准螺栓的连接节点提出的疲劳强度曲线大致相同,这应得到足够的重视。此外,本研究还展示了使用黏结螺栓连接的可行性研究。最后的研究是用高强度低合金结构钢板和用于金属黏结的丙烯酸结构黏结剂进行的。针对两个实际工程案例,使用线性化边界及Castillo和Fernández-Canteli模型对疲劳实验数据进行统计分析。最终提出疲劳设计曲线,并与欧洲和北美规范中的几个设计建议进行比较。 | Jose Antonio Fonseca de Oliveira Correia Bruno Alexandre Silva Pedrosa Patricia Cordeiro Raposo Abilio Manuel Pinho De Jesus Helena Maria dos Santos Gervisio Grzegorz Stanislaw Lesiukc Carlos Alberto da Silva Rebelo Rui Artur Bartolo Calcada Luis Alberto Proenca Simoes da Silva | 2017 | Engineering2017，3，6： | 1 |
| 11 | Tomato root dis- tribution, yield and fruit quality under different subsurface drip irri- gation regimes and depths显示文摘 | Machado Rui M A Oliveira Maria Do Rosario G | 2005 | Irrigation Science2005，24，1： | 1 |
| 12 | Co-expression of monocarboxylate transporter 1 (MCT1) and its chaperone (CD147) is associated with low survival in patients with gastrointestinal stromal tumors (GISTs)显示文摘 | Ant?nio Talvane Torres Oliveira Céline Pinheiro Adhemar Longatto-Filho Maria Jose Brito Olga Martinho Delcio Matos André Lopes Carvalho Vinícius Lima Vazquez Thiago Buosi Silva Cristovam Scapulatempo Sarhan Sydney Saad Rui Manuel Reis Fátima Baltazar | 2012 | Journal of Bioenergetics and Biomembranes2012，，1： | 1 |
| 13 | Impacto da idade no tratamento e resultados após enfarte agudo do miocárdio em particular nos muito idosos显示文摘 | Ana Teresa Timóteo Ruben Ramos Alexandra Toste Ana Lousinha José Alberto Oliveira Maria Lurdes Ferreira Rui Cruz Ferreira | 2011 | Revista Portuguesa de Cardiologia2011，，12： | 1 |
| 14 | Gomparison of tomato root distributions by minirhizotron and destructive sampling 显示文摘 | Rui M Maria R Oliveira G | 2003 | Plant and Soil2003，255，1： | 1 |
| 15 | Tomato root distribution,yield and fruit quality under subsurface drip irrigation显示文摘 | Rui M A Machado Maria do Rosário Oliveira G | 2003 | Plant and soil2003，255，1： | 1 |
| 16 | Reforestation of burned stands: The effect of ectomycorrhizal fungi on Pinus pinaster establishment显示文摘 | Nadine R. Sousa Albina R. Franco Miguel A. Ramos Rui S. Oliveira Paula M.L. Castro | 2011 | Soil Biology and Biochemistry2011，，10： | 1 |
| 17 | Mitochondrial Involvement in Cardiac Apoptosis During Ischemia and Reperfusion: Can We Close the Box?显示文摘 | Nuno G. Machado Marco G. Alves Rui A. Carvalho Paulo J. Oliveira | 2009 | Cardiovascular Toxicology2009，，4： | 1 |
| 18 | EDDS and EDTA-enhanced zinc accumulation by solanum nig- rum inoculated with arbuscular mycorrhizal fungi grown in contaminated soil显示文摘 | Ana P G C Marques Rui S Oliveira Kalina A Samardjieva | 2008 | Chemosphere2008，70，6： | 1 |
| 19 | Hormonal control of Sertoli cell metabolism regulates spermatogenesis显示文摘 | Marco G. Alves Luís Rato Rui A. Carvalho Paula I. Moreira Sílvia Socorro Pedro F. Oliveira | 2013 | Cellular and Molecular Life Sciences2013，，5： | 1 |
| 20 | Tomato root distribution, yield and fruit quality under subsurface drip irrigation 显示文摘 | Rui M A Maria R Oliveira G | 2003 | Plant and Soil2003，255，： | 1 |
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