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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Prediction of impact damage in composite plates显示文摘 | Hou J P Petrinic N Ruiz C Hallett S R | 2006 | Composites Science and Technology2006，60，： | 1 |
| 3 | Impact loading of plates: An experimental investigation显示文摘 | Corran R S J Shadbolt P J Ruiz C | 1983 | InternationalJournal of Impact Engineering1983，1，1： | 1 |
| 4 | Germanium recovery from gasification fly ash: Evaluation of end-products obtained by precipitation methods 显示文摘 | ARROYO F FONT O FERNANDEZ-PEREIRA C QUEROL X JUAN R RUIZ C COCA P | 2009 | Journal of Hazardous Materials2009，167，123： | 1 |
| 5 | Reactivation of herpes virus-6 in a chronic myeloyd leukemia (CML) patient during treatment with dasatinib 显示文摘 | Garcia-Munoz R Ruiz de Gaona E Rodriguez-Otero P | 2007 | Haematologica2007，92，2： | 1 |
| 6 | Inducible nitric oxide synthase,nitrotyrosine,and apoptosis in Helicobacter pylori gastritis:effect of antibiotics and antioxidants 显示文摘 | Mannick EE Bravo LE Zarama G Realpe JL Zhang XJ Ruiz B Eonthan ETH Mera R Miller MJL Correa P | 1996 | Cancer Res1996，56，： | 1 |
| 7 | Acute respiratory distress syndrome in trauma patients : ICU mortality and prediction factors 显示文摘 | Navarrete - Navarro P Ruiz -Bailen M Rinera Fernandez R | 2000 | Intensive Care Med2000，26，： | 1 |
| 8 | Relative Acidifying Activity of Anionic Salts Commonly Used to Prevent Milk Fever显示文摘 | Goff J P R Ruize R L Horst | 2004 | Joumal of Dairy Science2004，87，5： | 1 |
| 9 | Maturation,fertilization and complete development of porcine oocytes matured under different systems显示文摘 | Coy P Ruiz S Romar R | 1998 | Theriogenology1998，51，： | 1 |
| 10 | Uncertainty management in the uint commitment problem显示文摘 | Ruiz P A Philbrick C R Zak E | 2009 | IEEE Transactions on Power Systems2009，24，2： | 1 |
| 11 | Performance evaluation of existing approaches for hybrid ad hoc networks across mobility models显示文摘 | FRANCISCO R J RUIZ P M GOMEZ S A | 2006 | Journal of Net Works2006，1，2： | 1 |
| 12 | Cellular localization and changes in expression of prolactin receptor isoforms in sheep ovary throughout the estrous cycle显示文摘 | Picazo R A Garcia Ruiz J P Santiago Moreno J | 2004 | Reproduction2004，128，5： | 1 |
| 13 | Impact Loading of Plates-An Experimental Investigation 显示文摘 | Corran R S J Shadbolt P J Ruiz C | 1983 | Int J Impact Eng1983，1，1： | 1 |
| 14 | Spatial pattern analysis of dominant species in the Prepuna: Gaining insight into community dynamics in the semi-arid, subtropical Andes显示文摘 | Lopez R P Alcazar D L Ruiz F Z | 2010 | Journal of Arid Environments2010，74，11： | 1 |
| 15 | Sternoclavicular brucellosis 显示文摘 | Ibafiez R Ruiz P Garcia-Chill6n A | 1987 | J Rheumatol1987，14，1： | 1 |
| 16 | Resistance to cold and heat stress: accumulation of phenolic compounds in tomato and watermel- on plants显示文摘 | Rivem R M Ruiz J M Garcia P C | 2001 | Plant Science2001，160，： | 1 |
| 17 | Microcellular Foaming of Polymethylmethacrylate in a Bath Supercritical CO2 Process: Effect of Microstructure on Compression Behavior显示文摘 | RUIZ J A R VIOT P DUMON M | 2010 | Journal of Applied Polymer Science2010，118，1： | 1 |
| 18 | Connective tissue growth factor is a biomarker and mediator ofkidney allograft fibrosis显示文摘 | Cheng O Thuillier R Sampson E Schultz G Ruiz P Zhang X etal | 2006 | Am J Transplant2006，406，： | 1 |
| 19 | Optimization of biomass fuelled systems for distributed power generation using particle swarm optimization 显示文摘 | Reche Lopez P Comes G M Ruiz R N | 2008 | Electric Power Systems Research2008，78，8： | 1 |
| 20 | Beacon-less geographic multicast routing in a real-world wireless sensor network testbed 显示文摘 | Sanchez J A Marin-Perez R Ruiz P M | 2012 | Wireless Networks2012，18，5： | 1 |
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