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| 1 | In vivo radiometric analysis of glucose uptake and distribution in mouse bone显示文摘Bone formation and remodeling occurs throughout life and requires the sustained activity of osteoblasts and osteoclasts,particularly during periods of rapid bone growth.Despite increasing evidence linking bone cell activity to global energy homeostasis,little is known about the relative energy requirements or substrate utilization of bone cells.In these studies,we measured the uptake and distribution of glucose in the skeleton in vivo using positron-emitting^(18)F-fluorodeoxyglucose([^(18)F]-FDG) and non-invasive,high-resolution positron emission tomography/computed tomography(PET/CT) imaging and ex vivo autoradiography.Assessment of [^(18)F]-FDG uptake demonstrated that relative to other tissues bone accumulated a significant fraction of the total dose of the glucose analog.Skeletal accumulation was greatest in young mice undergoing the rapid bone formation that characterizes early development.PET/CT imaging revealed that [^(18)F]-FDG uptake was greatest in the epiphyseal and metaphyseal regions of long bones,which accords with the increased osteoblast numbers and activity at this skeletal site.Insulin administration significantly increased skeletal accumulation of [^(18)F]-FDG,while uptake was reduced in mice lacking the insulin receptor specifically in osteoblasts or fed a high-fat diet.Our results indicated that the skeleton is a site of significant glucose uptake and that its consumption by bone cells is subject to regulation by insulin and disturbances in whole-body metabolism. | Meredith L Zoch Diane S Abou Thomas L Clemens Daniel LJ Thorek Ryan C Riddle | 2016 | Bone Research2016，4，1： | 9 |
| 2 | Hematopoietic stem cell-derived adipocytes and fibroblasts in the tumor microenvironment显示文摘The tumor microenvironment(TME) is complex and constantly evolving. This is due, in part, to the crosstalk between tumor cells and the multiple cell types that comprise the TME, which results in a heterogeneous population of tumor cells and TME cells. This review will focus on two stromal cell types, the cancerassociated adipocyte(CAA) and the cancer-associated fibroblast(CAF). In the clinic, the presence of CAAs and CAFs in the TME translates to poor prognosis in multiple tumor types. CAAs and CAFs have an activated phenotype and produce growth factors, inflammatory factors, cytokines, chemokines, extracellular matrix components, and proteases in an accelerated and aberrant fashion. Through this activated state, CAAs and CAFs remodel the TME, thereby driving all aspects of tumor progression, including tumor growth and survival, chemoresistance, tumor vascularization, tumor invasion, and tumor cell metastasis. Similarities in the tumorpromoting functions of CAAs and CAFs suggest that a multipronged therapeutic approach may be necessary to achieve maximal impact on disease. While CAAs and CAFs are thought to arise from tissues adjacent to the tumor, multiple alternative origins for CAAs and CAFs have recently been identified. Recent studies from our lab and others suggest that the hematopoietic stem cell, through the myeloid lineage, may serve as a progenitor for CAAs and CAFs. We hypothesize that the multiple origins of CAAs and CAFs may contribute to the heterogeneity seen in the TME. Thus, a better understanding of the origin of CAAs and CAFs, how this origin impacts their functions in the TME, and thetemporal participation of uniquely originating TME cells may lead to novel or improved anti-tumor therapeutics. | Ying Xiong Lindsay T Mc Donald Dayvia L Russell Ryan R Kelly Katie R Wilson Meenal Mehrotra Adam C Soloff Amanda C LaRue | 2015 | World Journal of Stem Cells2015，7，2： | 6 |
| 3 | Hypoxia-inducible factor-1a restricts the anabolic actions of parathyroid hormone显示文摘The hypoxia inducible factors(Hifs) are evolutionarily conserved transcriptional factors that control homeostatic responses to low oxygen. In developing bone, Hif-1 generated signals induce angiogenesis necessary for osteoblast specification, but in mature bone, loss of Hif-1 in osteoblasts resulted in a more rapid accumulation of bone. These findings suggested that Hif-1 exerts distinct developmental functions and acts as a negative regulator of bone formation. To investigate the function of Hif-1a in osteoanabolic signaling, we assessed the effect of Hif-1a loss-of-function on bone formation in response to intermittent parathyroid hormone(PTH). Mice lacking Hif-1a in osteoblasts and osteocytes form more bone in response to PTH, likely through a larger increase in osteoblast activity and increased sensitivity to the hormone. Consistent with this effect, exposure of primary mouse osteoblasts to PTH resulted in the rapid induction of Hif-1a protein levels via a post-transcriptional mechanism. The enhanced anabolic response appears to result from the removal of Hif-1a-mediated suppression of b-catenin transcriptional activity. Together, these data indicate that Hif-1a functions in the mature skeleton to restrict osteoanabolic signaling. The availability of pharmacological agents that reduce Hif-1a function suggests the value in further exploration of this pathway to optimize the therapeutic benefits of PTH. | Julie L Frey David P Stonko Marie-Claude Faugere Ryan C Riddle | 2014 | Bone Research2014，2，1： | 2 |
| 4 | The pharmacology of impulsive behaviour in rats Ⅵ: the effects of ethanol and selective serotonergic drugs on response choice with varying delays of reinforcement显示文摘 | Evenden J L Ryan C N | 1999 | Psychopharmacology1999，146，： | 1 |
| 5 | A redeseription of Cryptosporidium galli Pavlasek, 1999 (Apicompl- exa: Cryptosporidiidae) from birds 显示文摘 | Ryan U M Xiao L Read C | 2003 | J Parasitol2003，89，： | 1 |
| 6 | Cancer- related Fatigue: the Scale of the Problem显示文摘 | Hofman M Ryan J L Figueroa-Moseley C D | 2007 | Oncologist2007，12，1： | 1 |
| 7 | The Siberian Lithosphere Traverse: Mantle Terranes and the Assembly of the Siberian Craton显示文摘 | GRIFFIN W L RYAN C G KAMINSKY F V | 1999 | Tectono- physics1999，310，1234： | 1 |
| 8 | Placenta accreta postpartum 显示文摘 | Ryan G L Quinn T J Syrop C H | 2002 | Obstet Gynecol2002，100，11： | 1 |
| 9 | Mechanical properties of the velopharynx in obese patients with obstructive sleep apnea显示文摘 | Ryan C F Love L L | | 0，，3： | 1 |
| 10 | Trace elements in sulfide inclusions from Yakutian diamonds显示文摘 | Bulanova G P Griffin W L Ryan C G | 1996 | Contributions to Mineralogy and Petrology1996，124，2： | 1 |
| 11 | Exosomal signaling during hypoxia mediates microvascular endothelial cell migration and vasculogenesis显示文摘 | Salomon C Ryan J Sobrevia L | 2013 | PLoS One2013，8，68： | 1 |
| 12 | Cultivating creativity in conservation science显示文摘 | Aslan C E Pinsky M L Ryan M E | 2014 | Conservation Biology2014，28，2： | 1 |
| 13 | NCCN Clinical Practice Guidelines in Oncology:rectal cancer 显示文摘 | Engstrom PF Arnoletti JP Benson AB 3rd Chen YJ Choti MA Cooper HS Covey A Dilawari RA Early DS Enzinger PC Fakih MG Fleshman J Jr Fuchs C Greta JL Kiel K Knol JA Leong LA Lin E Mulcahy MF Rao S Ryan DP Saltz L Shibata D Skibber JM Sofocleous C Thomas J Venook AP Willett C | 2009 | J Natl Compr Canc Netw2009，7，： | 1 |
| 14 | Stability of the total antioxidant capacity and total polyphenol content of 23 commercially available vegetable juices before and after in vitro digestion measured by FRAP,DPPH,ABTS and FolinCiocalteu methods显示文摘 | Wootton B P C Moran A Ryan L | | 0，，01： | 1 |
| 15 | Differential expression of chime rice Ca MV-tomato proteinase inhibitor I gene in leaves of transformed nightshade,tobacco and alfalfa plants显示文摘 | Narvaez-vasquez I Orozco-Cardenas M L Ryan C A | 1992 | Plant Mol Biol1992，，20： | 1 |
| 16 | Barley 13-glucan extracts as rich sources o显示文摘 | Thondre P S Ryan L Henry C J K | 2011 | Food Chemis- try2011，126，1： | 1 |
| 17 | GDNF protects the cochlea against noise damage显示文摘 | Keithley E M Ma C L Ryan A F | 1998 | Neuroreport1998，13，： | 1 |
| 18 | Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning显示文摘 | Samuel Davis Thomas H Aldrich Pamela F Jones Ann Acheson Debra L Compton Vivek Jain Terence E Ryan Joanne Bruno Czeslaw Radziejewski Peter C Maisonpierre George D Yancopoulos | 1996 | Cell1996，，7： | 1 |
| 19 | A redescription of Cryptosporidiumgalli Pavlasek,1999 (Apicomplexa: Cryptosporidiidae) from birds显示文摘 | Ryan UM Xiao L Read C | 2003 | Parasitol2003，，89： | 1 |
| 20 | Designing an interactive local and global decision support system for air- craft carrier deck scheduling 显示文摘 | RYAN J C CUMMINGS M L ROY N | 2011 | Proceedings AIAA Info- tech2011，10，6： | 1 |
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