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| 1 | Hypoxia-inducible factor-1a restricts the anabolic actions of parathyroid hormone显示文摘The hypoxia inducible factors(Hifs) are evolutionarily conserved transcriptional factors that control homeostatic responses to low oxygen. In developing bone, Hif-1 generated signals induce angiogenesis necessary for osteoblast specification, but in mature bone, loss of Hif-1 in osteoblasts resulted in a more rapid accumulation of bone. These findings suggested that Hif-1 exerts distinct developmental functions and acts as a negative regulator of bone formation. To investigate the function of Hif-1a in osteoanabolic signaling, we assessed the effect of Hif-1a loss-of-function on bone formation in response to intermittent parathyroid hormone(PTH). Mice lacking Hif-1a in osteoblasts and osteocytes form more bone in response to PTH, likely through a larger increase in osteoblast activity and increased sensitivity to the hormone. Consistent with this effect, exposure of primary mouse osteoblasts to PTH resulted in the rapid induction of Hif-1a protein levels via a post-transcriptional mechanism. The enhanced anabolic response appears to result from the removal of Hif-1a-mediated suppression of b-catenin transcriptional activity. Together, these data indicate that Hif-1a functions in the mature skeleton to restrict osteoanabolic signaling. The availability of pharmacological agents that reduce Hif-1a function suggests the value in further exploration of this pathway to optimize the therapeutic benefits of PTH. | Julie L Frey David P Stonko Marie-Claude Faugere Ryan C Riddle | 2014 | Bone Research2014，2，1： | 2 |
| 2 | Relaxin increases secretion of matrix metalloproteinase-2 and matrix metalloproteinase-9 during uterine and cervical growth and remodeling in the pig 显示文摘 | LENHART J A RYAN P L OHLETH K M | 2001 | Endocrinology2001，142，9： | 1 |
| 3 | The laser drilling of multi-layer aerospace material systems显示文摘 | A Corcoran L Sexton B Seaman P Ryan G Byrne | 2002 | Journal of Materials Processing Tech2002，，1： | 1 |
| 4 | Stable isotope incorporation triples the upper mass limit for determination of elemental composition by accurate mass measurement显示文摘 | Rodgers Ryan P Blumer Erin N Hendrickson Christopher L | 2000 | Journal of the American Society for Mass Spectrometry2000，10，11： | 1 |
| 5 | An improved un- derstanding of soil Cd risk to humans and low cost meth- ods to phytoextract Cd from contaminated soils to prevent soil Cd risks 显示文摘 | Chaney R L Reeves P G Ryan J A | 2004 | Biometals2004，17，： | 1 |
| 6 | The Characterization ofOxotremorine induced Hypothermic Response in the Rat 显示文摘 | Ryan P M Kelly J P Chambers P L | 1996 | Pharmacol Toxicol1996，79，5： | 1 |
| 7 | Poly-L-Lysine induces fibrosis on alginate microcapsules via the induction of cytokines显示文摘 | STRAND B L RYAN T L INT VELD P | 2001 | Cell Transplant2001，10，3： | 1 |
| 8 | Trace elements in sulfide inclusions from Yakutian diamonds显示文摘 | Bulanova G P Griffin W L Ryan C G | 1996 | Contributions to Mineralogy and Petrology1996，124，2： | 1 |
| 9 | Co translational,in- traribosomal cleavage of polypeptides by the foot-and mouth dis ease virus 2A peptide显示文摘 | De Felipe P Hughes L E Ryan M D | 2003 | J Biol Chem2003，278，11： | 1 |
| 10 | Self-determination in a work organization显示文摘 | DECI E L CONNELL J P RYAN R M | 1989 | Journal of Applied Psychology1989，74，4： | 1 |
| 11 | Self-determination in a work organization显示文摘 | DECI E L CONNELL J P RYAN R M | 1989 | Journal of Applied Psychology1989，74，： | 1 |
| 12 | An improved understanding of soil Cd risk to humans and low cost methods to phytoextract Cd from contaminated soils to provent soil Cd risks 显示文摘 | Chaney R L Reeves P G Ryan J A | 2004 | Biometals2004，，17： | 1 |
| 13 | Urinary levels of insecticide metabolites and DNA damage in human sperm显示文摘 | MEEKER J D SINGH N P RYAN L | 2004 | Human Reproduction2004，19，11： | 1 |
| 14 | Toughening by nanostructure显示文摘 | Ruiz-Pe' rez L Royston G J Fairclough P A Ryan A J | | 0，，： | 1 |
| 15 | Stability of the total antioxidant capacity and total polyphenol content of 23 commercially available vegetable juices before and after in vitro digestion measured by FRAP,DPPH,ABTS and FolinCiocalteu methods显示文摘 | Wootton B P C Moran A Ryan L | | 0，，01： | 1 |
| 16 | Lithium abundance and isotope systematics of forearc serpentinites, Conical Sea- mount, Mariana forearc: Insights into the mechanics of slab- mantle exchange during subduction显示文摘 | Benton L D Ryan J G Savov I P | 2004 | Geochemistry Geo- physics Geosystems2004，5，8： | 1 |
| 17 | Intrinsic need satisfac tion: A motivational basis of performance and weil-being in two work settingsl 显示文摘 | BAARD P P DECI E L RYAN R M | 2004 | J Appl Soc Psychol2004，34，10： | 1 |
| 18 | The relation of intrinsic need satisfaction to performance and wellbeing in two work settings显示文摘 | BAARD P P DECI E L RYAN R M | 2004 | Journal of Applied Social Psychology2004，34，： | 1 |
| 19 | Barley 13-glucan extracts as rich sources o显示文摘 | Thondre P S Ryan L Henry C J K | 2011 | Food Chemis- try2011，126，1： | 1 |
| 20 | Aluminum toxicity in roots:an investigation of spatial sensitivity and the role of the root cap显示文摘 | Ryan P R Ditomaso J M Kochian L V | 1993 | Journal of Experimental Botany1993，44，： | 1 |
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