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| 1 | 运用PTEN和ERG免疫染色区分针吸活检组织中前列腺导管内癌以及高级别PIN显示文摘前列腺导管内癌和高级别上皮内瘤变(PIN)在治疗方案上有着显著的区别,但二者的针吸活检组织很难区分。在前列腺根治标本中,作者发现运用PTEN和ERG的免疫组化染色可以解决这一难题。作者在实验中进一步验证在针吸标本中这些标志物是否有用。单独或组合的免疫标记法运用于形态学明确的导管内癌、PIN、交界性导管内增生的活检,后者缺乏类似于导管内癌的形态学准则而比PIN更令人担忧。 | Morais C L Han J S Gordetsky J 徐磊 孙咏梅 | 2015 | 临床与实验病理学杂志2015，31，4： | 11 |
| 2 | 曹雪涛院士科研团队论文荣膺中国百篇最具影响国际学术论文--长链非编码RNA1nc-DC通过STAT3调控人DC的分化和功能显示文摘树突状细胞(DC)是免疫系统中重要的抗原提呈细胞,其成熟和功能状态决定着免疫应答的走向和强度。哺乳动物基因组能够转录产生大量的长链非编码RNA(long noncoding RNA,IncRNA),其在免疫系统中的功能还知之甚少。
曹雪涛院十科研团队王品副教授课题组采用了转录组芯片二代测序高通量筛选方法、RNA-pulldown、ChIP-seq等技术展开了对IncRNA在DC分化和功能中作用的研究,发现并鉴定了特异性高表达于DC的1ncRNA,命名为1nc-DC,其可通过抑制STAT3去磷酸化,从而促进DC分化和功能。该研究成果发表于Science杂志[2014,344(6181):310-313],并于2015年12月被评为“中国百篇最具影响国际学术论文”。 | wang p xue y han y lin l wu c xu s jiang z xu j liu q cao x | 2016 | 中国肿瘤生物治疗杂志2016，23，1： | 10 |
| 3 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 4 | Role of interventional radiology in the management of acute gastrointestinal bleeding显示文摘Acute gastrointestinal bleeding(GIB) can lead to significant morbidity and mortality without appropriate treatment. There are numerous causes of acute GIB including but not limited to infection, vascular anomalies, inflammatory diseases, trauma, and malignancy. The diagnostic and therapeutic approach of GIB depends on its location, severity, and etiology. The role of interventional radiology becomes vital in patients whose GIB remains resistant to medical and endoscopic treatment. Radiology offers diagnostic imaging studies and endovascular therapeutic interventions that can be performed promptly and effectively with successful outcomes. Computed tomography angiography and nuclear scintigraphy can localize the source of bleeding and provide essential information for the interventional radiologist to guide therapeutic management with endovascular angiography and transcatheter embolization. This review article provides insight into the essential role of Interventional Radiology in the management of acute GIB. | Raja S Ramaswamy Hyung Won Choi Hans C Mouser Kazim H Narsinh Kevin C McCammack Tharintorn Treesit Thomas B Kinney | 2014 | World Journal of Radiology2014，6，4： | 8 |
| 5 | Unsteady wake over a line ar turbine blade cascade with air and CO2 film injection: part II-effect on film effect iv eness and heat transfer distribution显示文摘 | Ou S Han J C Mehendale A B | 1994 | Journal of Turbomachinery1994，116，10： | 2 |
| 6 | Photovoltaic properties of close-space sublinated CdTe solar cell显示文摘 | Han B W Park S C Ahn J H | 1998 | Solar Energy1998，64，5： | 2 |
| 7 | Engrafted bone marrow-derived flk-(1+) mesenchymal stem cells regenerate skin tissue显示文摘 | Deng W Han Q Liao L Li C Ge W Zhao Z You S Deng H Murad F Zhao RC | 2006 | 中国生物学文摘2006，20，5： | 2 |
| 8 | Fe-Mn martensitic alloys for control of noise and vibration in engineering applications 显示文摘 | Balk S H Kim J C Han D W etal | 2006 | Materials Science and Engineering A2006，，： | 1 |
| 9 | Sorption of the herbicide mefenacet in soils显示文摘 | Lu Y Han S K Zhang C D | 2001 | Environmental Contamination and Toxicology2001，66，1： | 1 |
| 10 | Optimum Design of forging Processes Using Nonlinear Finite Element Analysis显示文摘 | Han C S Grandhi R V Srinivasan R | 1993 | AIAA Journal1993，，31： | 1 |
| 11 | The inhibitory effect of polysaccarides isolated from Phellinus linteus on tumor growth and metastasis显示文摘 | Han S B Lee C W | 1999 | Immunopharmacology1999，，41： | 1 |
| 12 | Transglutaminase-dependent modulation of transctiption factor Sp1 activity显示文摘 | Han J A Park S C | 2000 | Mol Cells2000，10，： | 1 |
| 13 | Cluster analysis based on fuzzy equivalence relation显示文摘 | Liang G S Chou T Y Han T C | 2005 | European Journal of Operational Research2005，166，1： | 1 |
| 14 | Magnetic property of Sm2Fe17Nx films grown by RF magnetron sputtering显示文摘 | Kim J E Han J S Kim E C | 2004 | J Magn Magn Mater2004，，272： | 1 |
| 15 | Finite element analysis of Lamb wave propagation in a thin aluminum plate 显示文摘 | Han S J Palazotto A N Leakeas C L | 2009 | Journal of Aerospace Engineering2009，22，2： | 1 |
| 16 | Correlations of the first normal stress difference with shear stress and of the storage modulus with loss modulus for homopolymers 显示文摘 | Han C D Jhon M S | 1986 | Jour- nal of Applied Polymer Science1986，32，3： | 1 |
| 17 | Heat transfer enhancement inchannels with turbulence promoters显示文摘 | Han J C Park J S Lei C K | 1985 | Journal of Engi-neering for Gas Turbines and Power1985，107，3： | 1 |
| 18 | Piperine inhibition of 1-methyl4- phenylpyridinium-induced mitochondrial dysfunction and cell death in PC12 cells显示文摘 | Lee C S Han E S Kim Y K | 2006 | Eur J Pharmaco12006，537，13： | 1 |
| 19 | Wear Behaviour of Aluminium Matrix Composite Materials 显示文摘 | Lee C S Kim Y H Han K S | 1990 | Journal of Materials Science1990，，3： | 1 |
| 20 | Characteristic analysis of electrodynamic suspension device with permanent magnet Halbach array显示文摘 | Han W C Hyung S H Je S B | | 0，，7： | 1 |
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