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| 1 | 一项中断时间序列研究与集群随机试验:减少耐药细菌在重症监护室中定植和传播的干预措施显示文摘背景 重症监护室(ICU)是耐药细菌传播的高危科室,在设置标准预防措施时缺乏对"全面筛查和隔离携带或感染耐药细菌者"效果评估的对照研究,本研究评估此干预措施对减少ICU中耐药细菌的定植与传播的效果. | 曾翠 吴安华 Derde L P G Cooper B S Goossens H | 2014 | 中国感染控制杂志2014，13，1： | 23 |
| 2 | USING DISPLACED CONE REPRESENTATION IN DEA MODELS FOR NONDOMINATED SOLUTIONSIN MULTIOBJECTIVE PROGRAMMING显示文摘Concepts revolving around 'displaced cones' are used to extend the ideas of nondominated solutions in multiobjective programming. Necessary and sufficient conditions are formed around the additive models of DEA to idelltify nondominated solutions. This provdes a basis for effecting contacts with other disciplines and other parts of DEA. | W. W. Cooper (Graduate School Of Business, University of Texas at Austin, Austin, Texas, USA 78712-1174)WEI Quanling (Department of Information Management, People’s University of China, Beliing 100872, China) G. Yu (Department of MSIS, University of Texas | 1997 | Systems Science and Mathematical Sciences1997，10，1： | 17 |
| 3 | case of familial hyperlipoproteinemia type Ⅲ hypertriglyceridemia induced acute pancreatitis: role for outpatient apheresis maintenance therapy显示文摘Hypertriglyceridemic pancreatitis(HTGP) accounts for up to 10% of acute pancreatitis presentations in nonpregnant individuals and is the third most common cause of acute pancreatitis after alcohol and gallstones. There are a number of retrospective studies and case reports that have suggested a role for apheresis and insulin infusion in the acute inpatient setting. We report a case of HTGP in a male with hyperlipoproteinemia type Ⅲ who was treated successfully with insulin and apheresis on the initial inpatient presentation followed by bi-monthly outpatient maintenance apheresis sessions for the prevention of recurrent HTGP. We also reviewed the literature for the different inpatient and outpatient management modalities of HTGP. Given that there are no guidelines or randomized clinical trials that evaluate the outpatient management of HTGP, this case report may provide insight into a possible role for outpatient apheresis maintenance therapy. | Mohannad Abou Saleh Emad Mansoor Gregory S Cooper | 2017 | World Journal of Gastroenterology2017，23，40： | 10 |
| 4 | 抗甲状腺药物的副作用显示文摘抗甲状腺药物是治疗甲状腺功能亢进症的主要方法,尤其是由Graves病所致者。尽管一般情况下抗甲状腺药物是安全的,但是它的副作用限制了某些病人的使用。基于致病的严重程度将副作用分为轻度和严重两种。大剂量他巴唑(methimazole,MMI)(400mg或以上)时所有副作用都常见,但是丙基硫氧嘧啶(propyl-thiouracil,PTU)没有明显的剂量相关性。最常见的轻度副作用有皮疹、关节痛、胃肠不适,常规剂量时发生于5%病人;脱发、涎腺炎、肌病、味觉和嗅觉异常亦有发生。常见的严重副作用是粒细胞减少症的症状明显的多关节炎,严重的系统性腺管炎或药物诱发的狼疮(常见于抗中性粒细胞胞浆抗体阳性者)和PTU相关。他巴唑引起的胆汁淤积性肝毒性反应较PTU引起的潜在的致命肝细胞反应为轻。低凝血酶原血症和胰岛素自身免疫综合征是极少见的严重副作用。学习目的:复习抗甲状腺药物少见的副作用和推荐治疗,尤其是否该终止治疗;了解抗甲状腺药物引起的粒细胞缺乏症的可能机制、临床表现和治疗;比较主要抗甲状腺药物的肝毒性。 | David S Cooper,MD 李玉秀 | 2001 | 世界医学杂志2001，5，10： | 7 |
| 5 | 2型糖尿病患者采用血管紧张素转换酶抑制剂治疗后血清肌酐急性升高及其继续治疗对主要临床结局的影响显示文摘血管紧张素转换酶抑制剂开始治疗后血清肌酐急性升高≥30%时推荐停药。但血清肌酐升高后继续服药或停药对主要临床结局的长期影响仍不明确。在ADVANCE(糖尿病与血管疾病行动:培哚普利-吲达帕胺与达美康缓释片对照评估)试验中,11 140例糖尿病患者在6周活性导入期后随机采用培哚普利-吲达帕胺或安慰剂治疗。 | Ohkuma T Jun M Rodgers A Cooper ME Glasziou P Hamet P Harrap S Mancia G Marre M Neal B Perkovic V Poulter N Williams B Zoungas S Chalmers J Woodward M 赵狄 练桂丽 | 2019 | 中华高血压杂志2019，27，1： | 6 |
| 6 | Plecanatide-mediated activation of guanylate cyclase-C suppresses inflammation-induced colorectal carcinogenesis in Apc+/Min-FCCC mice显示文摘AIM To evaluate the effect of orally administered plecanatide on colorectal dysplasia in Apc^(+/Min-FCCC) mice with dextran sodium sulfate(DSS)-induced inflammation. METHODS Inflammation driven colorectal carcinogenesis was induced in Apc^(+/Min-FCCC) mice by administering DSS in their drinking water. Mice were fed a diet supplemented with plecanatide(0-20 ppm) and its effect on the multiplicity of histopathologically confirmed polypoid,flat and indeterminate dysplasia was evaluated. Plecanatide-mediated activation of guanylate cyclase-C(GC-C) signaling was assessed in colon tissues by measuring cyclic guanosine monophosphate(cG MP) by ELISA, protein kinase G-II and vasodilator stimulated phosphoprotein by immunoblotting. Ki-67, c-myc and cyclin D1 were used as markers of proliferation. Cellular levels and localization of b-catenin in colon tissues were assessed by immunoblotting and immunohistochemistry, respectively. Uroguanylin(UG) and GC-C transcript levels were measured by quantitative reverse transcription polymerase chain reaction(RT-PCR). A mouse cytokine array panel was used to detect cytokines in the supernatant of colon explant cultures. RESULTS Oral treatment of Apc^(+/Min-FCCC) mice with plecanatide produced a statistically significant reduction in the formation of inflammation-driven polypoid, flat and indeterminate dysplasias. This anti-carcinogenic activity of plecanatide was accompanied by activation of cG MP/GC-C signaling mediated inhibition of Wnt/b-catenin signaling and reduced proliferation. Plecanatide also decreased secretion of pro-inflammatory cytokines(IL-6, IL-1 TNF), chemokines(MIP-1, IP-10) and growth factors(GCSF and GMCSF) from colon explants derived from mice with acute DSS-induced inflammation. The effect of plecanatidemediated inhibition of inflammation/dysplasia on endogenous expression of UG and GC-C transcripts was measured in intestinal tissues. Although GC-C expression was not altered appreciably, a statistically significant increase in the level of UG transcripts was detected in the proximal small intestine and colon, potentially due to a reduction in intestinal inflammation and/or neoplasia. Taken together, these results suggest that reductions in endogenous UG, accompanied by dysregulation in GC-C signaling, may be an early event in inflammation-promoted colorectal neoplasia; an event that can potentially be ameliorated by prophylactic intervention with plecanatide.CONCLUSION This study provides the first evidence that orally administered plecanatide reduces the multiplicity of inflammation-driven colonic dysplasia in mice, demonstrating the utility for developing GC-C agonists as chemopreventive agents. | Wen-Chi L Chang Shet Masih Anusha Thadi Viren Patwa Apoorva Joshi Harry S Cooper Vaseem A Palejwala Margie L Clapper Kunwar Shailubhai | 2017 | World Journal of Gastrointestinal Pharmacology and Therapeutics2017，8，1： | 5 |
| 7 | 难治性疼痛和高血压在急性B型主动脉夹层中的重要性:国际急性主动脉夹层登记的意见显示文摘急性B型主动脉夹层患者,可表现出对药物治疗无效的反复、难治性疼痛和(或)难治性高血压,当出现这些症状时有时可作为介入治疗的指征。研究者利用国际急性主动脉夹层登记(international registry of a-cute aortic dissection,IRAD)的资料调查难治性疼痛和(或)难治性高血压对急性B型主动脉夹层患者临床转归的影响。 | 张玲玉 叶鹏 Trimarchi S Eagle KA Nienaber CA Pyeritz RE Jonker FH Suzuki T O'Gara PT Hutchinson SJ Rampoldi V Grassi V Bossone E Muhs BE Evangelista A Tsai TT Froehlich JB Cooper JV Montgomery D Mein-hardt G Myrmel T Upchurch GR Sundt TM Issel-bacher EM | 2010 | 中华高血压杂志2010，18，12： | 4 |
| 8 | The human application of gene therapy to re-program T-cell specificity using chimeric antigen receptors显示文摘The adoptive transfer of T cells is a promising approach to treat cancers. Primary human T cells can be modified using viral and non-viral vectors to promote the specific targeting of cancer cells via the introduction of exogenous T-cell receptors(TCRs) or chimeric antigen receptors(CARs). This gene transfer displays the potential to increase the specificity and potency of the anticancer response while decreasing the systemic adverse effects that arise from conventional treatments that target both cancerous and healthy cells. This review highlights the generation of clinical-grade T cells expressing CARs for immunotherapy, the use of these cells to target B-cell malignancies and, particularly, the first clinical trials deploying the Sleeping Beauty gene transfer system, which engineers T cells to target CD19+ leukemia and non-Hodgkin's lymphoma. | Alan D Guerrero Judy S Moyes Laurence JN Cooper | 2014 | Chinese Journal of Cancer2014，33，9： | 4 |
| 9 | Colorectal cancer surveillance:What's new and what's next?显示文摘The accumulated evidence from two decades of randomized controlled trials has not yet resolved the question of how best to monitor colorectal cancer(CRC)survivors for early detection of recurrent and metachronous disease or even whether doing so has its intended effect.A new wave of trial data in the coming years and an evolving knowledge of relevant biomarkers may bring us closer to understanding what surveillance strategies are most effective for a given subset of patients.To best apply these insights,a number of important research questions need to be addressed,and new decision making tools must be developed.In this review,we summarize available randomized controlled trial evidence comparing alternative surveillance testing strategies,describe ongoing trials in the area,and compare professional society recommendations for surveillance.In addition,we discuss innovations relevant to CRC surveillance and outline a research agenda which will inform a more risk-stratified and personalized approach to follow-up. | Johnie Rose Knut Magne Augestad Gregory S Cooper | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 10 | 交流互鉴 合作共赢——中外高级别人文交流机制综述显示文摘党中央、国务院高度重视中外人文交流,将其确立为党和国家对外交往的重要战略。人文交流与战略互信、经贸合作一道,已成为中国对外关系发展的三大支柱,是推动双边和多边关系健康发展的重要力量。习近平主席、李克强总理在国际交往中多次强调密切中外人民往来、厚植中外友好民意基础的重要性。刘延东副总理亲自挂帅担任中俄、中美、中英、中欧、中法和中印尼六大高级别中外人文交流机制中方委员会主席,领导和指导机制中方成员单位与有关国家和地区深入开展人文交流与合作。中外高级别人文交流机制的建设,有力地促进中外民众的相互了解、相互认知、相互理解,不断拓展中外人文交流的深度和广度,在促进合作其赢和推动世界和平发展方面发挥着积极重要的作用。 | The Office of People-to-People Dialogue Mechanisms Department of International Cooperation and Exchanges,Ministry of Education of the People’s Republic of China | 2016 | 神州学人2016，0，5： | 2 |
| 11 | 喷雾机雾滴运行时间和沉降规律的试验显示文摘利用光电原理,采用湿度传感器和毫秒计设计了测量雾滴运行时间的试验方案,并测量了4种常见喷嘴在不同机器前进速度和喷雾压力下的雾滴运行时间。结果表明,在喷雾机正常工作状态下,由于雾锥角的存在,雾滴总是超前于喷杆到达目标物上,这个时间上的提前量可以为变量喷雾系统的响应时间作必要的时间补偿。并通过采用三因素三水平的正交试验和方差分析,说明了喷嘴类型对雾滴运行时间的影响极为显著,而机器前进速度对雾滴运行时间的影响在5%的水平上显著。利用荧光跟踪试验,研究了3种喷嘴的不同时刻的沉降规律,从雾滴沉降的角度揭示了空心锥喷嘴存在很大的漂移性。 | 刘青 祁力钧 傅泽田 王俊 Cooper S E | 2007 | 农业机械学报2007，38，6： | 2 |
| 12 | Subclinical thyroid disease显示文摘 | David S Cooper Bernadette Biondi | 2012 | 2012 (9821)2012，，9821： | 2 |
| 13 | Global land cover mapping from MODIS: algorithms and early results显示文摘 | M.A Friedl D.K McIver J.C.F Hodges X.Y Zhang D Muchoney A.H Strahler C.E Woodcock S Gopal A Schneider A Cooper A Baccini F Gao C Schaaf | 2002 | Remote Sensing of Environment2002，，1： | 2 |
| 14 | The safety of tenofovir disoproxil fumarate for the treatment of HIV infection in adults: the first 4 years显示文摘 | Mark R Nelson Christine Katlama Julio S Montaner David A Cooper Brian Gazzard Bonaventura Clotet Adriano Lazzarin Knud Schewe Joep Lange Christina Wyatt Sue Curtis Shan-Shan Chen Stephen Smith Norbert Bischofberger James F Rooney | 2007 | AIDS2007，，10： | 2 |
| 15 | IDEA and AR-IDEA: Models for dealing with imprecise data in DEA显示文摘 | Cooper W W Park K S Yu G | 1999 | Management Science1999，45，4： | 1 |
| 16 | Obesity in adults with Down syndrome: a ease-control study显示文摘 | Melville C A Cooper S A Grother C W | 2005 | Journal of Intellectual Disability Research2005，49，2： | 1 |
| 17 | Development of drought resistant cultivars using physiological and morphological traits in rice显示文摘 | Fukai S Cooper M | 1995 | Field Crops Research1995，40，： | 1 |
| 18 | The treatment of wastewater from the leather industry显示文摘 | COOPER D R SHUTTLEWORTH S G SLABBERT N P | 1984 | Water PoUution Control1984，83，4： | 1 |
| 19 | Improving the sensitivity of the Barthel Index for stroke rehabilitation显示文摘 | Shah S Vanclay F Cooper B | 1989 | Journal of Clinical Epidemiology1989，42，8： | 1 |
| 20 | The efficacy and safety of B-cell depletion with anti-CD20 monoclonal antibody in adults with chronic immune thrombocytopenic purpura显示文摘 | COOPER N STASI R CUNNINGHAM-RUNDLES S | 2004 | Br J Haematol2004，125，： | 1 |
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