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| 1 | Clinical scenarios for the use of S100β as a marker of hepatic encephalopathy显示文摘AIM: To evaluate the association between serum concentrations of S100β in patients with cirrhosis and the presence of low grade hepatic encephalopathy(HE).METHODS: This was a cross-sectional study. The population was categorized into four groups healthy subjects, cirrhosis without HE, cirrhosis with covert hepatic encephalopathy(CHE) and cirrhosis with overt HE. Kruskal-Wallis, Mann Whitney's U with Bonferroni adjustment Spearman correlations and area under the ROC were used as appropriate.RESULTS: A total of 61 subjects were included, 46 cirrhotic patients and 15 healthy volunteers. S100β values were different among all groups, and differences remained significant between groups 1 and 2(P < 0.001), and also between groups 2 and 3(P = 0.016), but not between groups 3 and 4. In cirrhotic patients with HE S100β was higher than in patients without HE [0.18(0.14-0.28) ng/m L vs 0.11(0.06-0.14) ng/m L, P < 0.001]. There was a close correlation between serum concentrations of S100β and psychometric hepatic encephalopathy score in patients with cirrhosis without HE compared to the patients with cirrhosis with CHE(r =-0.413, P = 0.019). ROC curve analysis yielded > 0.13 ng/m L as the best cutoff value of S100β for the diagnosis of HE(sensitivity 83.3%, specificity 63.6%).CONCLUSION: Serum concentrations of S100β are higher in patients with cirrhosis than in healthy volunteers, and are further increased in the presence of hepatic encephalopathy. The results suggest that serum biomarkers such as S100β could help in the correct characterization of incipient stages of HE. | Andrés Duarte-Rojo Astrid Ruiz-Margáin Ricardo U Macias-Rodriguez Francisco Javier Cubero José Estradas-Trujillo Rosa Ma Munoz-Fuentes Aldo Torre | 2016 | World Journal of Gastroenterology2016，22，17： | 4 |
| 2 | Low phase angle is associated with the development of hepatic encephalopathy in patients with cirrhosis显示文摘AIM Evaluate the association between phase angle and the development of hepatic encephalopathy in the longterm follow-up of cirrhotic patients.METHODS This was a prospective cohort study. Clinical, nutritional and biochemical evaluations were performed. MannWhitney's U and χ2 tests were used as appropriate. Kaplan-Meier curves and Cox proportional Hazards analysis were used to evaluate the prediction and incidence of hepatic encephalopathy.RESULTS Two hundred and twenty were included; the most frequent etiology of cirrhosis was hepatitis C infection, 52% of the patients developed hepatic encephalopathy(18.6% covert and 33.3% overt); the main precipitating factors were infections and variceal bleeding. KaplanMeier curves showed a higher proportion of HE in the group with low phase angle(39%) compared to the normal phase angle group(13%)(P = 0.012). Furthermore, creatinine and phase angle remained independently associated to hepatic encephalopathy in the Cox regression multivariate analysis [hazard ratio = 1.80(1.07-3.03)]. CONCLUSION In our cohort of patients low phase angle was associated with an increased incidence of hepatic encephalopathy. Phase angle is a useful nutritional marker that evaluates cachexia and could be used as a part of the integral assessment in patients with cirrhosis. | Astrid Ruiz-Margáin Ricardo Ulises Macías-Rodríguez Javier Ampuero Francisco Javier Cubero Luis Chi-Cervera Silvia L Ríos-Torres Andrés Duarte-Rojo Ángeles Espinosa-Cuevas Manuel Romero-Gómez Aldo Torre | 2016 | World Journal of Gastroenterology2016，22，45： | 4 |
| 3 | Differential expression and function of Arabidopsis thaliana NHX Na^+/H^+ antiporters in the salt stress response显示文摘 | Yokoi1 S Francisco J Q Cubero B | 2002 | The Plant Journal2002，30，5： | 1 |
| 4 | Expression of activation molecules in neutrophils,monocytes and lymphocytes from patients with unstable angina treated with stent implantation显示文摘 | Sánchez-Margalet V Cubero JM Martín-Romero C | 2004 | Clin Chem Lab Med2004，42，3： | 1 |
| 5 | Optimized computer vision system for automatic pre-grading of citrus fruit in the field using a mobile platform显示文摘 | CUBERO S ALEIXOS N ALBERT F | 2014 | Prec Agr2014，15，1： | 1 |
| 6 | Deve- lopment of a Machine for the Automatic Sorting of Pome- granate( Punica Granatum)Arils Based on Computer Vision 显示文摘 | BLASCO J CUBERO S G6MEZ-SANCHIS J | 2009 | Journal of Food Engineering2009，90，1： | 1 |
| 7 | Differential expression and function of Arabidopsis thaliana NHX Na+/H+ antiporters in the salt stress response显示文摘 | Yokoi S Francisco J Q Cubero B | 2002 | The Plant Journal2002，30，5： | 1 |
| 8 | Differential expression and function of Arabidopsis thaliana NHX Na+/H+antiporters in the salt stress response显示文摘 | Yokoi S Quintero F J Cubero B | 2002 | The Plant Journal2002，30，5： | 1 |
| 9 | Confirmation that the Er3 gene, conferring resistance to Erysiphe pisi in pea, is a different gene from erl and er2 genes 显示文摘 | Fondevilla S Cubero J I Rubiales D | 2011 | Plant Breeding2011，130，2： | 1 |
| 10 | Differential expression and function ofArabidopsis thaliana NHX Na+/H+ antiporters in the salt stress response显示文摘 | YOKOI S QUINTERO F J CUBERO B | | 0，，05： | 1 |
| 11 | Differential expression and function of Arabidopsis thaliana NHX Na +/H +antiporters in the salt stress response显示文摘 | YOKOI S QUINTERO F J CUBERO B | 2002 | Plant J2002，30，5： | 1 |
| 12 | Differential expression and function of Arabidopsis thaliana NHX Na+/H+ antiporters in the salt stress response显示文摘 | YOKOI S QUINTERO F J CUBERO B RUIZ T BRESSAN R A HASEGAWA P M PARDO J M | 2002 | The Plant Journal2002，30，5： | 1 |
| 13 | Differential expression and function of Arabidopsis thaliana NHX Na +/H + antiporters in the salt stress response 显示文摘 | YOKOI S QUINTERO F J CUBERO B | 2002 | Plant J2002，30，5： | 1 |
| 14 | Differential expression and function of Arabidopsis thaliana NHX Na +iH + antiporters in the salt stress response 显示文摘 | Yokoi S Quintero F J Cubero B | 2002 | The Plant Journal2002，30，5： | 1 |
| 15 | Development of a machine for the automatic sorting of pomegranate (Punicagranatum) mils based on computer vision显示文摘 | Blasco J Cubero S G6mez- Sanchis J | 2009 | Journal of Food Engineering2009，90，1： | 1 |
| 16 | Differential expression and function of Arabidopsis thaliana NHX Na+/H+?antiporters in the salt stress response显示文摘 | Yokoi S Quintero F J Cubero B | 2002 | Plant Journal2002，30，5： | 1 |
| 17 | Advances in machine vision applications for automatic inspection and quality evaluation of fruits and vegetables 显示文摘 | Cubero S Aleixos N Molto E | 2011 | Food Bioprocess Technology2011，，4： | 1 |
| 18 | Advances in machine vision applications for automatic inspection and quality evaluation of fruits and vegetables显示文摘 | CUBERO S ALEIXOS N MOLTO E | 2011 | Food and Bioprocess Technology2011，4，4： | 1 |
| 19 | Plas- monic absorption in textured silver back reflectors of thin film solar cells显示文摘 | HAUG F J S()DERSTROM T CUBERO O | 2008 | J Appl Phys2008，104，6： | 1 |
| 20 | Inflammatory response to coronary stent implantation in patients with unstable angina显示文摘 | S~inehez-Margalet V Cubero JM Martin-Romero C | 2002 | Clin Chem Lab Med2002，40，8： | 1 |
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