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| 1 | Interactions between hepatic iron and lipid metabolism with possible relevance to steatohepatitis显示文摘The liver is an important site for iron and lipid metabolism and the main site for the interactions between these two metabolic pathways. Although conflicting results have been obtained, most studies support the hypothesis that iron plays a role in hepatic lipogenesis. Iron is an integral part of some enzymes and transporters involved in lipid metabolism and, as such, may exert a direct effect on hepatic lipid load, intrahepatic metabolic pathways and hepatic lipid secretion. On the other hand, iron in its ferrous form may indirectly affect lipid metabolism through its ability to induce oxidative stress and inflammation, a hypothesis which is currently the focus of much research in the field of nonalcoholic fatty liver disease/non-alcoholic steatohepatitis (NAFLD/NASH). The present review will first discuss how iron might directly interact with the metabolism of hepatic lipids and then consider a new perspective on the way in which iron may have a role in the two hit hypothesis for the progression of NAFLD via ferroportinand the iron regulatory molecule hepcidin. The review concludes that iron has important interactions with lipid metabolism in the liver that can impact on the development of NAFLD/NASH. More defined studies are required to improve our understanding of these effects. | Umbreen Ahmed Patricia S Latham Phillip S Oates | 2012 | World Journal of Gastroenterology2012，18，34： | 20 |
| 2 | Heme in intestinal epithelial cell turnover, differentiation, detoxification, inflammation, carcinogenesis, absorption and motility显示文摘胃肠道被经历包含两极分裂,区别和细胞死亡的经常的更新的一张单层上皮衬里。另外,上皮的衬里分开由保护上皮免受被突破的伤害的防御机制从内部周围的无菌的环境发生在肠的腔的消化和吸收的敌对过程。对这些防御过程中央是合成他我和它的分解代谢由他我氧合酶(惊讶) 。饮食他我也是为被收起的身体的铁的重要来源由 enterocyte 未经触动。这评论在肠道在 heme/HO 的多样的性质上描述最近的文学。在房间 cycle/apoptosis, xenobiotics 的 detoxification,氧化压力,发炎,结肠癌的发展, heme 铁吸收和肠的活动性的规定的 heme/HO 的角色明确地被检验。 | Phillip S Oates Adrian R West | 2006 | World Journal of Gastroenterology2006，12，27： | 8 |
| 3 | Mechanisms of heme iron absorption:Current questions and controversies显示文摘Iron is a critical micronutrient, and iron derived from heme contributes a large proportion of the total iron absorbed in a typical Western diet. Heme iron is absorbed by different mechanisms than non-heme iron, but despite considerable study over many years these mechanisms remain poorly understood. This review provides an overview of the importance of heme iron in the diet and discusses the two prevailing hypotheses of heme absorption; namely receptor mediated endocytosis of heme, and direct transport into the intestinal enterocyte by recently discovered heme transporters. A specific emphasis is placed on the questions surrounding the site of heme catabolism and the identity of the enzyme that performs this task. Additionally, we present the hypothesis that a non-heme iron transport protein may be required for heme iron absorption and discuss the experiences of our laboratory in examining this hypothesis. | Adrian R West Phillip S Oates | 2008 | World Journal of Gastroenterology2008，14，26： | 5 |
| 4 | Aldose reductase inhibition protects diabetic and nondiabetic rat hearts from ischemic injury显示文摘 | Ramasamy R Oates P J Schaefer S | 1997 | Diabetes1997，46，2： | 1 |
| 5 | Relationship between soil structure and runoff/soil loss after 24 years of conservation tillage显示文摘 | Zhang G S Chan K Y Oates A | 2006 | Soil and Tillage Research2006，92，12： | 1 |
| 6 | The single screw extruder as a bioreactor for sago starch hydrolysis显示文摘 | Govindasamy S Campanella O H Oates C G | 1997 | Food Chemistry1997，60，1： | 1 |
| 7 | Enzymatic hydrolysis and saccharification optimization of sago starch in a twin-screw extruder 显示文摘 | Govindasamy S Camparella O H Oates C G | 1997 | Journal of Food Engineering1997，32，4： | 1 |
| 8 | Enzymatic hydrolysis of sago in a twin-screw extruder显示文摘 | Govindasamy S Campanella 0 H Oates C G | 1997 | Journal of food engineer1997，32，4： | 1 |
| 9 | Traumatic fracture of the stapes suprastructure following minor head injury 显示文摘 | Singh S Salib RJ Oates J | 2002 | J Laryngol Otol2002，116，： | 1 |
| 10 | Absence of deleted in azoospermia (DAZ) genes in spermatozoa of infertile men with somatic DAZ deletions显示文摘 | De Vries JW Repping S Oates R | 2001 | Fertil Steril2001，75，3： | 1 |
| 11 | Cyclooxygenase-2 promotes early atherosclerotic lesion formation in LDL receptor deficient mice显示文摘 | Burleigh ME Babaev VR Oates JA Harris RC Gautam S Riendeau D | 2002 | Circulation2002，105，15： | 1 |
| 12 | Identical relations in finite groups显示文摘 | Oates S Powell M B | | 0，，： | 1 |
| 13 | Clinical characterization of 42 oligospermic or azoospermic men with microdeletion of the AZFc region of the Y chromosome,and of 18 children conceived via ICSI 显示文摘 | Oates R D Silber S Brown L G | 2002 | Hum Reprod2002，17，11： | 1 |
| 14 | Enzymatic hydrolysis of sago starch in a twin- screw extruder 显示文摘 | Govindasamy S Campanella O H Oates C G | 1997 | Journal of Food Engineering1997，32，4： | 1 |
| 15 | Relationship between soil structure and runoff/soil loss after 24 years of conservation tillage显示文摘 | Zhang G S Chan K Y Oates A | 2007 | Soil&Tillage Research2007，92，12： | 1 |
| 16 | Glycemic controland implant stabilization in type 2diabetes mellitus显示文摘 | Oates TW Dowell S Robinson1M | 2009 | JDent Res2009，88，4： | 1 |
| 17 | Clinical characterization of 42 oligospermic or azoospermic men with microdeletion of the AZFc region of the Y chromosome and of 18 children conceived via ICSI显示文摘 | Oates R D Silber S Brown L G | 2002 | Hum Rep rod2002，17，： | 1 |
| 18 | Glycosyltransferase inhibitors:synthesis of D-threo-PDMP,L-threo-PDMP,and other brain glucosylceramide synthase inhibitors from D-or L-serine显示文摘 | Mitchell S A Oates B D Razavi H | | 0，，24： | 1 |
| 19 | Celecoxib first report of thrombosis in patients with connective tissue diseases treated with specific cyclooxygenase inhibitors: a report of four cases显示文摘 | Crofford LJ Oates JC McCune WJ Gupta S Kaplan MJ Catella-Lawson F | 2000 | Arthritis and Rheumatism2000，43，： | 1 |
| 20 | Zebrafish stat3 is expressed in restricted tissues during embryogenesis and statl rescues cytokine signaling in a STAT1-deficient human cell line 显示文摘 | Oates A C WoUberg P Pratt S J | 1999 | Dev Dyn1999，215，4： | 1 |
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