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| 1 | Role of antispasmodics in the treatment of irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS)is a long-lasting,relapsing disorder characterized by abdominal pain/discomfort and altered bowel habits.Intestinal motility impairment and visceral hypersensitivity are the key factors among its multifactorial pathogenesis,both of which require effective treatment.Voltage-gated calcium channels mediate smooth muscle contraction and endocrine secretion and play important roles in neuronal transmission.Antispasmodics are a group of drugs that have been used in the treatment of IBS for decades.Alverine citrate,a spasmolytic,decreases the sensitivity of smooth muscle contractile proteins to calcium,and it is a selective 5-HT1A receptor antagonist.Alverine,in combination with simethicone,has been demonstrated to effectively reduce abdominal pain and discomfort in a large placebo-controlled trial.Mebeverine is a musculotropic agent that potently blocks intestinal peristalsis.Non-placebo-controlled trials have shown positive effects of mebeverine in IBS regarding symptom control;nevertheless,in recent placebo-controlled studies,mebeverine did not exhibit superiority over placebo.Otilonium bromide is poorly absorbed from the GI tract,where it acts locally as an L-type calcium channel blocker,an antimuscarinic and a tachykinin NK2receptor antagonist.Otilonium has effectively reduced pain and improved defecation alterations in placebocontrolled trials in IBS patients.Pinaverium bromide is also an L-type calcium channel blocker that acts locally in the GI tract.Pinaverium improves motility disorders and consequently reduces stool problems in IBS patients.Phloroglucinol and trimethylphloroglucinol are non-specific antispasmodics that reduced pain in IBS patients in a placebo-controlled trial.Antispasmodics have excellent safety profiles.T-type calcium channel blockers can abolish visceral hypersensitivity in animal models,which makes them potential candidates for the development of novel therapeutic agents in the treatment of IBS. | Anita Annaházi Richárd Róka András Rosztóczy Tibor Wittmann | 2014 | World Journal of Gastroenterology2014，20，20： | 15 |
| 2 | New treatment strategies for malignant gliomas显示文摘 | Sathornsumetee S Rich JN | 2006 | 中国神经肿瘤杂志2006，4，2： | 5 |
| 3 | Epidemiologic characteristics of Helicobacter pylori infection in southeast Hungary显示文摘BACKGROUND Epidemiologic studies have revealed a decrease in the prevalence of Helicobacter pylori(H.pylori)infection in Western Europe.AIM To obtain data regarding the prevalence of H.pylori in Csongrád and Békés Counties in Hungary,evaluate the differences in its prevalence between urban and rural areas,and establish factors associated with positive seroprevalence.METHODS One-thousand and one healthy blood donors[male/female:501/500,mean age:40(19–65)years]were enrolled in this study.Subjects were tested for H.pylori IgG antibody positivity via enzyme-linked immunosorbent assay.Subgroup analysis by age,gender,smoking habits,alcohol consumption,and urban vs nonurban residence was also performed.RESULTS The overall seropositivity of H.pylori was 32%.It was higher in males(34.93%vs 29.2%,P=0.0521)and in rural areas(36.2%vs 27.94%,P=0.0051).Agricultural/industrial workers were more likely to be positive for infection than office workers(38.35%vs 30.11%,P=0.0095)and rural subjects in Békés County than those in Csongrád County(43.36%vs 33.33%,P=0.0015).CONCLUSION Although the prevalence of H.pylori infection decreased in recent decades in Southeast Hungary,it remains high in middle-aged rural populations.Generally accepted risk factors for H.pylori positivity appeared to be valid for the studied population. | Lenke Bálint Andrea Tiszai Gábor Kozák Ilona Dóczi Veronika Szekeres Orsolya Inczefi Georgina Ollé Krisztina Helle Richárd Róka András Rosztóczy | 2019 | World Journal of Gastroenterology2019，25，42： | 5 |
| 4 | Mo loading effect over Mo/Si:Ti catalysts in the oxidative dehydrogenation of ethane显示文摘 | Rich B Watson Umit S Ozkan | 2002 | J Catal2002，208，： | 2 |
| 5 | Motor Learning of a Dynamic Balancing Task After Stroke:Implicit Implications for Stroke Rehabilitation显示文摘 | Alison J Otrell Frank F Eves Rich S W Masters | 2006 | Physical Theropy2006，3，86： | 1 |
| 6 | Diagnosis and treatment of high-grade astrocytoma显示文摘 | Sathornsumetee S Rich JN Reardon DA | | 0，，04： | 1 |
| 7 | Vandetanib,a novel multitargeted kinase inhibitor,in cancer therapy显示文摘 | Sathornsumetee S Rich JN | | 0，，10： | 1 |
| 8 | Chemotherapy and cancer stem cells显示文摘 | Rich IN Bao S | 2007 | Cell Stem Cell2007，1，4： | 1 |
| 9 | Diagnosis and treatment of high-grade astrocytoma 显示文摘 | SATHORNSUMETEE S RICH JN REARDON DA | 2007 | Neurol Clin2007，25，4： | 1 |
| 10 | Four decades of continuing innovation with fluorouracil:current and future approaches to fluorouracil chemoradiation therapy显示文摘 | RICH T A SHEPARD R C MOSLEY S T | 2004 | J Clin Oncol2004，22，11： | 1 |
| 11 | A 210-GHz fr SiGe HBT with a non-self-aligned structure 显示文摘 | Jeng S J Tagannathan B Rich J S | 2001 | IEEE Elec Dev Lett2001，22，11： | 1 |
| 12 | Design and fabrication of high temperature superconducting field coils for a demonstration DC motor显示文摘 | CHAD H J RICH F S | 1993 | IEEE Trans on Applied Superconductivity1993，，： | 1 |
| 13 | Evidence for extensive overlap of sporophytic and gametophytic gene expression in Lycopersicon esculentum 显示文摘 | Tanksley S D Zamir D Rich C M | 1981 | Science1981，213，： | 1 |
| 14 | Role of video games in improving health-related outcomes:A systematic review显示文摘 | Primack B.A Carroll M.V MeNamara M Klem M.L King B Rich M.O Nayak S | | 0，，06： | 1 |
| 15 | Diagnostic morbidity of mental disorders among young suicides显示文摘 | Rich C L | 1992 | Int Rev Psychiatry1992，4，： | 1 |
| 16 | Diagnosis and treatment of high-grade astrocytoma显示文摘 | Sathornsumetee S Rich JN Reardon DA | 2007 | Neurol Clin2007，25，4： | 1 |
| 17 | Widespread A-to-I RNA editing of Alu-containing mRNAs in the human transcriptome显示文摘 | Athanasiadis A Rich A Maas S | 2004 | PLoS Biol2004，2，12： | 1 |
| 18 | Controlling enzyme-catalyzed regioselectivity in sugar esters synthesis显示文摘 | Rich J Bedell B A Dordick J S | 1995 | Biotechnol Bioeng1995，45，5： | 1 |
| 19 | The effect of high doses of calcium-channel blockers on survival in pulmonary hypertension显示文摘 | Rich S Kaufmann E Levy PS | 1992 | N Engl J Med1992，327，： | 1 |
| 20 | The effect of high doses of calcium-channel blockers on survival in primary pulmonary hypertension显示文摘 | Rich S Kaufmarm E Levy PS | 1992 | N Engl J Med1992，327，2： | 1 |
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