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| 1 | Early palliative care for patients with metastatic non-small-cell lung cancer显示文摘Comments This landmark article demonstrates that integration of early palliative care with standard oncologic practice shortly after diagnosis may improve quality of life,mood,and overall survival for adults with advanced non-small-cell lung cancer(NSCLC).If validated,these findings could support a paradigm shift in the care of adults with metastatic NSCLC and possibly patients with other tumor types characterized by short survival and high symptom burden. | Temel JS Greer JA Muzikansky A Gallagher ER Admane S Jackson VA Dahlin CM Blinderman CD Jacobsen J Pirl WF Billings JA Lynch TJ | 2010 | 中国肺癌杂志2010，13，9： | 165 |
| 2 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 3 | 具有低动脉粥样硬化风险特征的专业耐力运动员的亚临床冠状动脉疾病发病率显示文摘研究表明,具有冠状动脉疾病(coronary artery disease,CAD)危险因素的中老年(健将)运动员比久坐个体冠状动脉钙化(coronary artery calcium,CAC)评分更高。尚没有研究评估具有低动脉粥样硬化风险特征的专业运动员的CAD患病率。 | 刘莉 叶鹏 Merghani A Maestrini V Rosmini S Cox AT Dhutia H Bastiaenen R David S Yeo TJ Narain R Malhotra A Papadakis M Wilson MG Tome M AlFakih K Moon JC Sharma S | 2017 | 中华高血压杂志2017，25，6： | 8 |
| 4 | 补体B因子是代谢综合征模型代谢与心血管特征的一个决定因素显示文摘补体B因子(complenment factor B,CFB)在2型糖尿病及心血管病患者脂肪组织及血清中水平升高,但与疾病发病机制的因果关系不明确。自发性高血压大鼠(spontaneously hypertensive rats,SHR)脂肪组织及血清中CFB也升高。为明确CFB在代谢综合征中的作用,研究者在SHR中敲除Cfb基因。 | 赵狄 练桂丽 Coan PM Barrier M Alfazema N Carter RN Marion de Procé S Dopico XC Garcia Diaz A Thomson A Jackson-Jones LH Moyon B Webster Z Ross D Moss J Arends MJ Morton NM Aitman TJ | 2017 | 中华高血压杂志2017，25，8： | 3 |
| 5 | 早发性高血压患者中年时即出现高血压终末靶器官损害显示文摘早发高血压会增加社区心血管死亡的风险。早发高血压是否在中年时就可促发终末靶器官损害(target end-organ damage,TOD)的进展,目前仍不清楚。研究者纳入中青年人冠状动脉危险因素研究(coronary artery risk development in young adults,CARDIA)参与者2680例[平均年龄(50±4)岁,57%为女性],他们在1985-2011年间接受了多达8次系列血压测量(基线年龄范围18-30岁),并且在2010-2011年进行了左心室肥厚、冠状动脉钙化、白蛋白尿和舒张功能障碍的评估。 | 刘青(译) 叶鹏(审校) Suvila K McCabe EL Lehtonen A Ebinger JE Lima JAC Cheng S Niiranen TJ | 2019 | 中华高血压杂志2019，27，10： | 2 |
| 6 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 7 | Maternal obesity and diabetes as risk factors for adverse pregnancy outcomes : differences among 4 racial/ethnic groups 显示文摘 | Rosenberg TJ Garbers S Lipkind H | 2005 | Am J Public Health2005，95，： | 1 |
| 8 | Drug interaction: Volatile anesthetics and opiates显示文摘 | Glass PSP Gan TJ Howell S | 1997 | J Clin Anesth1997，9，： | 1 |
| 9 | Genomic structure and alternative spilicing of 519, a gene expressed late after T cell activation显示文摘 | O'Farrell S Goralski TJ | 1992 | J Immunol1992，148，12： | 1 |
| 10 | Cytotoxic lymphocytes require granzyme B for the rapid induction of DNA fragmentation and apoptosis in allogeneic target cells 显示文摘 | Wesselschmidt RL Shresta S Russell JH Ley TJ | 1994 | Cell1994，76，： | 1 |
| 11 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 12 | A review of the pharmacokinetics and pharcodynamics of remifentanil显示文摘 | Glass PS Gan TJ Howell S | 1999 | Anesth Analg1999，89，4： | 1 |
| 13 | Sleep apnea in 81 ambulatory male patients with arable heart failure: types and their prevalences, consequences, and presentations 显示文摘 | Javaheri S Parker TJ Liming JD | 1998 | Crculation1998，97，21： | 1 |
| 14 | Leptin suppression of insulin secretion by the activation of ATP-sensitive K+ channels in pancreaticβ-cells 显示文摘 | Kieffer TJ Heller S Leech CA | 1997 | Diabetes1997，46，6： | 1 |
| 15 | Galectin-3 marks activated maerophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunetion显示文摘 | Sharma I5C Pokharel S van Brakel TJ | 2004 | Circulation2004，110，： | 1 |
| 16 | Endothelialfunction testing as a biomarker of vascular disease显示文摘 | Verma S Buchanan MR Anderson TJ | 2003 | Circulation2003，108，17： | 1 |
| 17 | Granulomatouslobular mastitis显示文摘 | Going JJ Anderson TJ Wilkinson S | 1987 | J Clin Pathol1987，40，5： | 1 |
| 18 | Evaluation of voxel-based morphometry for focal lesion detection in individuals 显示文摘 | Mehta S Grabowski TJ Trivedi Y | 2003 | Neuroimage2003，20，3： | 1 |
| 19 | Autoregulated changes in stability of poly-bosome-bound-β-tubulin mRNAs are specified by the first translated nucleotides显示文摘 | YEN TJ GAY D A PACHTER J S | 1988 | Mol Cell Biol1988，8，1： | 1 |
| 20 | Association of the platelet glyco-protein Ia C807T gene polymorphism with nonfatal myocardial infarc-tion in younger patients显示文摘 | Santoso S Kunicki TJ Kroll H | | 0，，： | 1 |
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