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| 1 | 瑞舒伐他汀对存在亚临床动脉粥样硬化的低危人群颈动脉内膜中层厚度进展的影响——METEOR试验显示文摘背景:动脉粥样硬化往往在机体出现症状之前就已有所进展。目前,我们尚不清楚Framingham风险评分(Framinghaln risk score,FRS)较低的轻中度亚临床动脉粥样硬化中年人群是否能从治疗中获益。
目的:评价为期2年的他汀类药物治疗能否减缓颈动脉内膜中层厚度(carotid intimamedia thickness,CIMT)继续增厚或使粥样斑块消退。
设计、地点及参试者:“瑞舒伐他汀对内膜中层厚度影响的测评研究(Measuring Effects on Intima-Media Thickness:an Evaluation of Rosuvastatin,METEOR)”是2002年8月至2006年5月在美国及欧洲61个基层医疗中心开展的一项随机、双盲、安慰剂对照研究,共纳入984名参试者,有的参试者仅以年龄(平均年龄,57岁)为冠心病的危险因素,有的参试者10年内FRS低于10%、CIMT重庞增厚(1.2~3.5mm)、LDL胆固醇水平有所升高(平均值,154mg/dL)。
干预:参试者服用40mg瑞舒伐他汀或安慰剂。
主要观测指标:12个颈动脉位点最大CIMT的变化率(经B超检测);颈总动脉位点、颈动脉窦位点及颈内动脉位点最大CIMT的变化,颈总动脉位点平均CIMT的变化。仅在瑞舒伐他汀组中评估CIMT的消退情况。
结果:瑞舒伐他汀组参试者LDL胆固醇平均(SD)水平由基线时的155(24.1)mg/dL降至78(27.5)mg/dL,平均降低49%(与安慰剂组相比P〈0.001)。瑞舒伐他汀组12个颈动脉位点最大CIMT的变化值为-0.0014(95%CI,-0.0041~0.0014)mm/y,安慰剂组12个颈动脉位点最大CIMT的变化值为Q0131(95%CI,Q0087~Q0174)mm/y(P〈0.001)。瑞舒伐他汀组颈总动脉位点最大CIMT的变化值为-0.0038(95%CI,-0.0064~-0.0013)mm/y(P〈0.001),颈动脉窦位点最大CIMT的变化值为-0.0040(95%CI,-0.0090~0.0010)mm/y(P〈0.001),颈内动脉位点最大CIMT的变化值为0.0039(95%CI,-0.0009~0.0088)mm/y(P=0.02)。瑞舒伐他汀组颈总动脉位点平均CIMT的变化值为0.0004(95%CI,-0.0011~0.0019)mm/y(P〈0.001)。P值均为与安慰剂组相比。总的来说,瑞舒伐他汀具有良好的耐受性,很少引发严重的心血管不良事件(在2年内有6名参试者[0.86%]出现8起不良事件[1.1%])。
结论:对于FRS低于10%的亚临床动脉粥样硬化中年人群而言,瑞舒伐他汀能够在2年内显著降低最大CIMT的进展速率,与安慰剂相比差异具有统计学显著性。但是,瑞舒伐他汀无法诱导病变消退。今后,我们仍需开展大型远期试验来明确上述研究结果的临床意义. | John R. Crouse Ⅲ Joel S. Raichlen Ward A. Riley Gregory W. Evans Mike K. Palmer Daniel H. O' Leary Diederick E. Grobbee Michiel L. Bots 李军(译) | 2007 | 美国医学会杂志(中文版)2007，26，4： | 44 |
| 2 | Formation history and protolith characteristics of granulite facies metamorphic rock in Central Cathaysia deduced from U-Pb and Lu-Hf isotopic studies of single zircon grains显示文摘The petrochemical as well as zircon U-Pb and Lu-Hf isotopic studies of granulite facies metamorphic rock from the Taoxi Group in eastern Nanling Range, Central Cathaysia indicate that its protolith is the sedimentary rock with low maturation index. The clastic materials are mostly from middle Neoproterozoic (~736 Ma) granitoid rocks with minor Neoarchaean and Paleoproterozoic rocks. The timing of this Neoproterozoic magmatism is in agreement with the second period of magmatism widespread surrounding the Yangtze Block. Hf isotopic data indicate that the Neoproterozoic granitoids resulted from the recycled Paleoproterozoic mantle-derived crustal materials. The sedimentary rock was deposited in Late Neoproterozoic Era, and carried into low crust in Early Paleozoic. The partial melting of the meta-sedimentary rock took place at about 480 Ma and subsequently granulite facies metamorphism occurred at ca. 443 Ma. The zircons forming during this time interval (Early Paleozoic) show large Hf isotope variations, and their -Hf(t) values increase from -13.2 to +2.36 with decreasing age, suggesting the injection of mantle-derived materials during partial melting and metamorphism processes in the Early Paleozoic. Calculation results show that this metamorphic rock, if evolved to Mesozoic, has similar isotopic composition to the nearby Mesozoic high Si peraluminous granites, implying that this kind of granulite facies metamorphic rock is probably the source material of some Mesozoic peraluminous granitoids in eastern Nanling Range. | YU Jinhai ZHOU Xinmin Y. S. O'Reilly ZHAO Lei W. L. Griffin WANG Rucheng WANG Lijuan CHEN Xiaomin | 2005 | Chinese Science Bulletin2005，50，18： | 35 |
| 3 | 华北东部地幔改造作用和置换作用:单斜辉石激光探针研究显示文摘对山东蒙阴古生代金伯利岩中石榴石方辉橄榄岩、河南鹤壁新生代玄武岩中 铬尖晶石方辉橄榄岩、山东栖霞新生代玄武岩中央晶石二辉橄榄岩和山东山旺新生代 玄武岩中尖晶石(富CpX)二辉橄榄岩单斜辉石的常量、微量元素的研究和对比表明:华 北地块古生代稳定存在的克拉通岩石圈地幔在中、新生代其东部被具大洋地幔性质的 显生宙地幔不均匀地发生了置换作用,残存于南北重力梯度带(岩石圈减薄过渡带)上 的鹤壁浅部克拉通地幔除保存有置换作用前改造作用的丰富信息外,也包含有其深部 被置换后的地幔改造作用信息;郯庐断裂带东部栖霞的新生地幔仍保留有较多的大洋 地幔成分特征,而郯庐断裂带内山旺的新生地幔受后续地幔改造作用的影响有向大陆 地幔演化的趋向.发生于华北地块东部中、新生代的岩石圈巨厚减薄作用与地幔的置换 作用有关,由渐进的富CO_2流体或碳酸岩熔体对岩石圈地幔的交代改造作用以及由此 所引起的熔体抽取作用是完成新生地幔对古老地幔置换作用的关键.郯庐断裂带等岩 石圈深大断裂为地幔改造作用和地幔置换作用提供了良好的通道作用. | 郑建平 路凤香 S. Y O’Reilly W. L. Griffin 张明 | 2000 | 中国科学(D辑)2000，30，4： | 27 |
| 4 | Cretaceous volcanic-intrusive magmatism in western Guangdong and its geological significance显示文摘Systematic zircon LA-ICPMS U-Pb dating reveals that Cretaceous volcanic-intrusive activities developed in western Guangdong. Representative volcanic rocks, i.e. Maanshan and Zhougongding rhyodacites, have zircon U-Pb isotopic ages of 100±1 Ma, and the intrusive ones in-cluding the Deqing monzonitic granite body and the Xinghua granodiorite body in the Shidong com-plex, as well as the Tiaocun granodiorite body in the Guangping complex yield ages of 99±2 Ma, ca. 100 Ma, and 104±3 Ma respectively. The biotite-granites of the Shidong complex main body (461±35 Ma) and that of the Guangping complex (444±6 Ma) are Caledonian. In spite of the big time interval between Cretaceous volcanic-intrusive magmatisms and Caledonian intrusive ones, both of them are characterized by enrichment in Rb, Th, Ce, Zr, Hf, Sm, depletion in Ba, Nb, Ta, P, Ti, Eu, and weakly REE tetrad effect. Eu negative anomalies are: Cretaceous volcanic rocks (Eu/Eu*=0.74), Cretaceous intrusive rocks (Eu/Eu*=0.35―0.58), Caledonian biotite granites (Eu/Eu*=0.31―0.34). Studies of Sr-Nd isotope data show that all these igneous rocks have high initial 87Sr/86Sr ratios (0.7105―0.7518), and low εNd(t) values (?7.23―?11.39) with their Nd two-stage model ages ranging from 1.6―2.0 Ga, which suggest that they all derived from the Proterozoic crustal basement of southeast China. The occurrence of Cretaceous volcanic-intrusive magmatisms in western Guangdong is related with the important lithospheric extension event in southeast China (including Nanling region) at ca. 100 Ma. The “volcanic line” defined by the large scale Mesozoic intermediate-acidic volcanic magmatisms in southeast China may further extend to the southwest margin of Nanling region. | S. Y. O’Reilly | 2006 | Science China Earth Sciences2006，49，7： | 5 |
| 5 | 手术中知晓事件的新分级标准显示文摘背景有外显记忆的手术中知晓事件的发生率仅为1/1000—2/1000。因其较罕见,为了更好的了解手术中知晓事件及其后遗效直,需要对大批量的研究数据进行统计。因此,对其进行标准描述和表达将很有价值。方法本研究创建了一种新的手术中知晓事件评估标准:0级:未发生手术中知晓;1级:仅存在听觉感知;2级:感知触觉(比如手术操作、气管插管);3级:感知痛觉;4级:感知麻痹(比如感到不能活动、说话或呼吸);5级:感知麻痹及痛觉。患者主述有恐惧、焦虑、窒息、末日感、濒死感及其他相关显性描述,另行附加“D”(distress[痛苦、悲伤])。本研究回顾了15项详细提供手术中知晓报告信息的研究。来自3个研究并创建了该项分级标准的5位麻醉医生,各自独立的评估了这些病例。另外20名相关人员(麻醉主治医生、麻醉住院医生、麻醉护士、医学生及其辅助工作人员),虽未参与该分级标准的创建,但也独立对手术中知晓事件进行了评估。用Flwiss’s κ系数评估观察者之间的一致性。结果对151例确认发生手术中知晓事件的成年病例进行数据分析。基础评估1~5级中,总体κ系数为0.851(95%可信区间CI0.847~0.856)。包括附加情感障碍“D”的评估中,总体κ系数为0.779(95%可信区间CI 0.776~0.783)。结论本研究创建了新的手术中知晓事件评估标准,在评估者间具有近乎完美的一致性,这将有助于手术中知晓事件的研究。 | George A. Mashour Roy K. Esaki Kevin K. Tremper David B. Glick Michael O'Connor Michael S. Avidan 潘鹏(译) 李文志(校) | 2009 | 麻醉与镇痛2009，，6： | 3 |
| 6 | 盆腔脏器支持组织研究(POSST):盆腔脏器支持组织缺陷的分布、临床定义及流行病学特点 | Swift S. Woodman P. O' Boyle A. 朱国栋 | 2005 | 世界核心医学期刊文摘(妇产科学分册)2005，0，7： | 3 |
| 7 | 紫杉醇洗脱支架与血管内近距离放射疗法治疗裸金属支架内再狭窄的比较:TAXUSVISR随机试验显示文摘Context: Restenosis within bare-metal stents is often treated with repeat percutaneous coronary intervention, although subsequent recurrence rates are high, with vascular brachytherapy(VBT) affording the best results. The effectiveness of drug-eluting stents in this setting has not been established. Objective: To investigate the safety and efficacy of the polymer-based, slow-release paclitaxel-eluting stent in patients with restenotic lesions after prior stent implantation in native coronary arteries. Design, Setting, and Patients: Prospective, multicenter, randomized trial conducted between June 6, 2003, and July 16, 2004, at 37 North American academic and community-based institutions in 396 patients with in-stent restenosis of a previously implanted bare-metal coronary stent(vessel diameter, 2.5-3.75 mm; lesion length, ≤ 46 mm). Interventions: Patients were randomly assigned to undergo angioplasty followed by VBT with a β source(n=201) or paclitaxel-eluting stent implantation(n=195). Clinical and angiographic follow-up at 9 months was scheduled in all patients. Main Outcome Measure: Ischemia-driven target vessel revascularization at 9 months. Results: Diabetes mellitus was present in 139 patients(35.1% ). Median reference vessel diameter was 2.65 mm and median lesion length was 15.3 mm. In the VBT group, new stents were implanted in 22 patients(10.9% )and in the paclitaxel-eluting stent group, multiple stents were required in 57 patients(29.2% ), with median stent length of 24 mm. Follow-up at 9 months was complete in 194 patients in the VBT group and 191 patients in the paclitaxel-eluting stent group(96.5% and 97.9% , respectively). For VBT and paclitaxel-eluting stents, respectively, the number of events and 9-month rates for ischemic target lesion revascularization were 27(13.9% ) vs 12(6.3% )(relative risk [RR], 0.45; 95% confidence interval [CI], 0.24-0.86; P=.01); for ischemic target vessel revascularization, 34(17.5% ) vs 20(10.5% )(RR, 0.60; 95% CI, 0.36-1.00; P=.046); and for overall major adverse cardiac events, 39(20.1% ) vs 22(11.5% )(RR, 0.57; 95% CI, 0.35-0.93; P=.02), with similar rates of cardiac death or myocardial infarction(10 [5.2% ] vs 7 [3.7% ]; RR, 0.71; 95% CI, 0.28-1.83; P=.48) and target vessel thrombosis(5 [2.6% ] vs 3 [1.6% ]; RR, 0.61; 95% CI, 0.15-2.50; P=.72). Angiographic restenosis at 9 months was 31.2% (53 of 170 patients) with VBT and 14.5% (25 of 172 patients) with paclitaxel-eluting stents(RR, 0.47; 95% CI, 0.30-0.71; P< .001). Conclusion: Treatment of bare-metal in-stent restenotic lesions with paclitaxel-eluting stents rather than angioplasty followed by VBT reduces clinical and angiographic restenosis at 9 months and improves event-free survival. Trial Registration: ClinicalTrials. gov Identifier: NCT00287573. | Stone G. W. Ellis S. G. O'Shaughnessy C. D. 任付先(译) 杜媛(校) | 2006 | 世界核心医学期刊文摘(心脏病学分册)2006，2，8： | 3 |
| 8 | Omega-3 supplementation and non-alcoholic fatty liver disease: A systematic review and meta-analysis显示文摘 | Helen M. Parker Nathan A. Johnson Catriona A. Burdon Jeffrey S. Cohn Helen T. O’Connor Jacob George | 2011 | Journal of Hepatology2011，，4： | 3 |
| 9 | MicroRNA-155 Promotes Autoimmune Inflammation by Enhancing Inflammatory T Cell Development显示文摘 | Ryan M. O’Connell Daniel Kahn William S.J. Gibson June L. Round Rebecca L. Scholz Aadel A. Chaudhuri Melissa E. Kahn Dinesh S. Rao David Baltimore | 2010 | Immunity2010，，4： | 3 |
| 10 | The second European evidence-based Consensus on the diagnosis and management of Crohn’s disease: Current management显示文摘 | A. Dignass G. Van Assche J.O. Lindsay M. Lémann J. S?derholm J.F. Colombel S. Danese A. D’Hoore M. Gassull F. Gomollón D.W. Hommes P. Michetti C. O’Morain T. ?resland A. Windsor E.F. Stange S.P.L. Travis | 2010 | Journal of Crohn’s and Colitis2010，，1： | 2 |
| 11 | Telaprevir- and Boceprevir-based Triple Therapy for Hepatitis C in Liver Transplant Recipients With Advanced Recurrent Disease: A Multicenter Study显示文摘 | Elizabeth C. Verna Varun Saxena James R. Burton Jacqueline G. O’Leary Jennifer L. Dodge Richard T. Stravitz Josh Levitsky James F. Trotter Gregory T. Everson Robert S. Brown Norah A. Terrault | 2015 | Transplantation2015，，8： | 2 |
| 12 | Pericardial Fat, Visceral Abdominal Fat, Cardiovascular Disease Risk Factors, and Vascular Calcification in a Community-Based Sample: The Framingham Heart Study显示文摘 | Guido A. Rosito Joseph M. Massaro Udo Hoffmann Frederick L. Ruberg Amir A. Mahabadi Ramachandran S. Vasan Christopher J. O’Donnell Caroline S. Fox | 2008 | Circulation2008，，5： | 2 |
| 13 | Metabolic syndrome: a closer look at the growing epidemic and its associated pathologies显示文摘 | S. O’Neill L. O’Driscoll | 2015 | Obes Rev2015，，1： | 2 |
| 14 | Survival After Resection of Ampullary Carcinoma: A National Population-Based Study显示文摘 | Jessica B. O'Connell MD Melinda A. Maggard MD Jesse Manunga MD James S. Tomlinson MD Howard A. Reber MD Clifford Y. Ko MD O. Joe Hines MD | 2008 | Annals of Surgical Oncology2008，，7： | 2 |
| 15 | Validation of the Capsule Endoscopy Crohn’s Disease Activity Index (CECDAI or Niv score): a multicenter prospective study显示文摘 | Y. Niv S. Ilani Z. Levi M. Hershkowitz E. Niv Z. Fireman S. O’Donnel C. O’Morain R. Eliakim E. Scapa N. Kalantzis C. Kalantzis P. Apostolopoulos E. Gal | 2012 | Endoscopy2012，，01： | 2 |
| 16 | Declining NAD + Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging显示文摘 | Ana P. Gomes Nathan L. Price Alvin J.Y. Ling Javid J. Moslehi Magdalene K. Montgomery Luis Rajman James P. White Jo?o S. Teodoro Christiane D. Wrann Basil P. Hubbard Evi M. Mercken Carlos M. Palmeira Rafael de Cabo Anabela P. Rolo Nigel Turner Eric L. Bel | 2013 | Cell2013，，7： | 2 |
| 17 | Ultrasound elastography as an adjuvant to conventional ultrasound in the preoperative assessment of axillary lymph nodes in suspected breast cancer: A pilot study显示文摘 | K. Taylor S. O’Keeffe P.D. Britton M.G. Wallis G.M. Treece J. Housden D. Parashar S. Bond R. Sinnatamby | 2011 | Clinical Radiology2011，，11： | 2 |
| 18 | A framework for mapping industrial emergence显示文摘 | R. Phaal E. O’Sullivan M. Routley S. Ford D. Probert | 2010 | Technological Forecasting & Social Change2010，，2： | 2 |
| 19 | C-Terminal Provasopressin (Copeptin) as a Novel and Prognostic Marker in Acute Myocardial Infarction: Leicester Acute Myocardial Infarction Peptide (LAMP) Study显示文摘 | Sohail Q. Khan Onkar S. Dhillon Russell J. O’Brien Joachim Struck Paulene A. Quinn Nils G. Morgenthaler Iain B. Squire Joan E. Davies Andreas Bergmann Leong L. Ng | 2007 | Circulation2007，，16： | 2 |
| 20 | A comparison of inflammation-based prognostic scores in patients with cancer. A Glasgow Inflammation Outcome Study显示文摘 | Michael J. Proctor David S. Morrison Dinesh Talwar Steven M. Balmer Colin D. Fletcher Denis St.J. O’Reilly Alan K. Foulis Paul G. Horgan Donald C. McMillan | 2011 | European Journal of Cancer2011，，17： | 2 |
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