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| 1 | Systematic review and meta-analysis on the association of tuberculosis in Crohn's disease patients treated with tumor necrosis factor-α inhibitors(Anti-TNFα)显示文摘AIM To perform a meta-analysis on the risk of developing Mycobacterium tuberculosis(TB) infection in Crohn's disease(CD) patients treated with tumor necrosis factoralpha(TNFα) inhibitors.METHODS A meta-analysis of randomized, double-blind, placebocontrolled trials of TNFα inhibitors for treatment of CD in adults was conducted. Arcsine transformation of TB incidence was performed to estimate risk difference. A novel epidemiologically-based correction(EBC) enabling inclusions of studies reporting no TB infection cases in placebo and treatment groups was developed to estimate relative odds.RESULTS Twenty-three clinical trial studies were identified, including 5669 patients. Six TB infection cases were reported across 5 studies, all from patients receiving TNFα inhibitors. Eighteen studies reported no TB infection cases in placebo and TNFα inhibitor treatment arms. TB infection risk was significantly increased among patients receiving TNFα inhibitors, with a risk difference of 0.028(95%CI: 0.0011-0.055). The odds ratio was 4.85(95%CI: 1.02-22.99) with EBC and 5.85(95%CI: 1.13-30.38) without EBC.CONCLUSION The risk of TB infection is higher among CD patients receiving TNFα inhibitors. Understanding the immunopathogenesis of CD is crucial, since using TNFα inhibitors in these patients could favor mycobacterial infections, particularly Mycobacterium avium subspecies paratuberculosis, which ultimately could worsen their clinical condition. | Brent L Cao Ahmad Qasem Robert C Sharp Latifa S Abdelli Saleh A Naser | 2018 | World Journal of Gastroenterology2018，24，25： | 4 |
| 2 | Blood classical monocytes phenotype is not altered in primary non-small cell lung cancer显示文摘AIM: To evaluate the M1 and M2 monocyte phenotype in patients with non-small cell lung cancer(NSCLC) compared to controls. Also, to examine the expression of Th1 and Th2 cytokines in plasma of NSCLC vs controls. METHODS: Freshly prepared peripheral blood mononuclear cells samples were obtained from patients with NSCLC(lung adenocarcinoma and squamous cell lung carcinoma) and from non-cancer controls. Flow cytometry was performed to investigate M1 and M2 phenotypes in peripheral monocytes(classical monocytes CD14+, CD45+ and CD16-) using conventional surface markers. Th1 and Th2 cytokine production was alsoanalysed in the plasma using cytometric bead array technique. RESULTS: There were no significant difference in expression of M1(HLA-DR) and/or M2 markers(CD163 and CD36) markers on classical monocytes in patients with NSCLC compared to non-cancer controls. Expression of CD11 b, CD11 c, CD71 and CD44 was also shown to be similar in patients with NSCLC compared to noncancer controls. Th1 and Th2 cytokines [interleukin(IL)-1β, IL-2, IL-4, IL-5, IL-8, IL-10, IL-12(p70), tumor necrosis factor(TNF)-α, TNF-β, and interferon-γ] analysis revealed no significant difference between patients with NSCLC and non-cancer controls. CONCLUSION: This study shows no alteration in peripheral monocyte phenotype in circulating classical monocytes in patients with NSCLC compared to noncancer controls. No difference in Th1 and Th2 cytokine levels were noted in the plasma of these patients. | Saleh A Almatroodi Christine F Mc Donald Allison L Collins I an A Darby Dodie S Pouniotis | 2014 | World Journal of Clinical Oncology2014，5，5： | 2 |
| 3 | Microbial ex- pression in soil:methods, applications and challenges 显示文摘 | Saleh L S Miller M Campbell R G | 2005 | Microbiol Methods2005，63，： | 1 |
| 4 | Protein splicing in cis and in trans显示文摘 | Saleh L Perler FB | 2006 | Chem Rec2006，6，4： | 1 |
| 5 | Notch2 controls prolactin and insulin-like growth factor binding protein-1 expression in decidualizing human stromal cells of early pregnancy显示文摘 | Otti GR Saleh L Velicky P | 2014 | PLo S One2014，9，11： | 1 |
| 6 | Use of PCR-targeted Mutagenesis to disrupt production of fusaricidin-type antifun-gal antibiotics in Paenibacillus polymyxa显示文摘 | Jingru L Perrin K B Saleh S | 2007 | Applied and En-vironmental Microbiology2007，，： | 1 |
| 7 | Quantification of teicoplanin in plasma by LC-MS with online sample clean-up and comparison with QMS assay显示文摘 | Mueller DM von Eckardstein A Saleh L | 2014 | Clin Chem Lab Med2014，52，6： | 1 |
| 8 | Stiffness characteristics and inter-fragmentary displacements with different hybrid external fixators显示文摘 | Yang L Nayagam S Saleh M | 2003 | Clin Biomech ( Bristol Avon)2003，18，： | 1 |
| 9 | Production of pro- and anti-inflammatory cytokines of human placental trophoblasts in response to pathogenic bacteria 显示文摘 | Grisinger G Saleh L Baucr S | 2001 | J Soc Gynecol Investing2001，8，6： | 1 |
| 10 | Production of pro-and antiinflammatory cytokines of human placental trophoblasts in response to pathogenic bacteria显示文摘 | Grisinger G Saleh L Baucr S | 2001 | J Soc Gynecol Investing2001，8，6： | 1 |
| 11 | Aggregation kinetics of multiwalled carbon nanotubes in aquatic systems: measurements and environmental implications 显示文摘 | Saleh N Pfefferle L Elimelech M | 2008 | Environmental science & technology2008，42，21： | 1 |
| 12 | Protein splicing in cis and in trans显示文摘 | SALEH L PERLER F B | | 0，，04： | 1 |
| 13 | Protein splicing in cis and in trans显示文摘 | Saleh L Perler F B | 2006 | Chem Rec2006，6，4： | 1 |
| 14 | Stiffness characteristics and inter-fragmentary displacements with different hybrid external fixators显示文摘 | Yang L Nayagam S Saleh M | 2003 | Clin Biomech (Bristol Avon)2003，18，2： | 1 |
| 15 | Optical Networking: Past, Present, and Future显示文摘 | BERTHOLD J SALEH A BLAIR L | 2008 | Journal of Lightwave Technology2008，26，9： | 1 |
| 16 | Maternal and neonatal complications of substance abuse in Iranian pregnant women显示文摘 | SALEH G S FALLAHIAN M HAGHIGHI L | 2012 | Acta Med Iran2012，50，： | 1 |
| 17 | Activation and stabilization of drugs by supramolecular pKa shifts:drug-delivery applications tailored for cucurbiturils显示文摘 | Saleh N Koner A L Nau W M | 2008 | Angew Chem Int Ed Engl2008，47，29： | 1 |
| 18 | An artificial nanopore for molecular sensing 显示文摘 | SALEH 0 A SOHN L L | 2003 | Nano Lett2003，3，1： | 1 |
| 19 | Aggregation kinetics of multiwalled carbon nanotubes in aquatic systems : measurements andenvironmental implications 显示文摘 | Saleh N C Pfefferle L D Elimeleeh M | 2008 | Environmental Science & Technology2008，42，21： | 1 |
| 20 | Role of endothelin in preeclampsia and hypertension following antiangiogenesis treatment显示文摘 | Saleh L Danser JA van den Meiracker AH | 2016 | Curr Opin Nephrol Hypertens2016，25，2： | 1 |
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