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| 1 | Gender influence on defecographic abnormalities in patients with posterior pelvic floor disorders显示文摘AIM:To compare defecographic abnormalities in symptomatic men and women and to analyze differences between men and age-and symptom-matched women.METHODS:Sixty-six men(mean age:55.4 years,range:20-81 years) who complained of constipation and/or fecal incontinence and/or pelvic pain underwent defecography after intake of a barium meal.Radiographs were analyzed for the diagnosis of rectocele,enterocele,intussusception and perineal descent.They were compared with age-and symptom-matched women(n = 198) who underwent defecography during the same period.RESULTS:Normal defecography was observed in 22.7% of men vs 5.5% of women(P < 0.001).Defecography in men compared with women showed 4.5%vs 44.4%(P < 0.001) rectocele,and 10.6% vs 29.8%(P < 0.001) enterocele,respectively.No difference was observed for the diagnosis of intussusception(57.6% vs 44.9%).Perineal descent at rest was more frequent in women(P < 0.005).CONCLUSION:For the same complaint,diagnosis of defecographic abnormalities was different in men than in women:rectocele,enterocele and perineal descent at rest were observed less frequently in men than in women. | Céline Savoye-Collet Guillaume Savoye Edith Koning Anne-Marie Leroi Jean-Nicolas Dacher | 2010 | World Journal of Gastroenterology2010，16，4： | 8 |
| 2 | Magnetic resonance imaging may predict deep remission in patients with perianal fistulizing Crohn's disease显示文摘AIM To evaluate the imaging course of Crohn's disease(CD) patients with perianal fistulas on long-term maintenance anti-tumor necrosis factor(TNF)-α therapy and identify predictors of deep remission.METHODS All patients with perianal CD treated with anti-TNF-α therapy at our tertiary care center were evaluated by magnetic resonance imaging(MRI) and clinical assessment. Two MR examinations were performed: at initiation of anti-TNF-α treatment and then at least 2 years after. Clinical assessment(remission, response and non-response) was based on Present's criteria. Rectoscopic patterns, MRI Van Assche score, and MRI fistula activity signs(T2 signal and contrast enhancement) were collected for the two MR examinations. Fistula healing was defined as the absence of T2 hyperintensity and contrast enhancement on MRI. Deep remission was defined as the association of both clinical remission, absence of anal canal ulcers and healing on MRI. Characteristics and imaging patterns of patients with and without deep remission were compared by univariate and multivariate analyses.RESULTS Forty-nine consecutive patients(31 females and 18 males) were included. They ranged in age from 14-70 years(mean, 33 years). MRI and clinical assessment were performed after a mean period of exposure to anti-TNF-α therapy of 40 ± 3.7 mo. Clinical remission, response and non-response were observed in 53.1%, 20.4%, and 26.5% of patients, respectively. Deep remission was observed in 32.7% of patients. Among the 26 patients in clinical remission, 10 had persisting inflammation of fistulas on MRI(T2 hyperintensity, n = 7; contrast enhancement, n = 10). Univariate analysis showed that deep remission was associated with the absence of rectal involvement and the absence of switch of anti-TNF-α treatment or surgery requirement. Multivariate analysis demonstrated that only the absence of rectal involvement(OR = 4.6; 95%CI: 1.03-20.5) was associated with deep remission.CONCLUSION Deep remission is achieved in approximately one third of patients on maintenance anti-TNF-α therapy. Absence of rectal involvement is predictive of deep remission. | Lucie Thomassin Laura Armengol-Debeir Cloé Charpentier Valerie Bridoux Edith Koning Guillaume Savoye Céline Savoye-Collet | 2017 | World Journal of Gastroenterology2017，23，23： | 5 |
| 3 | Thiol WR-1065 and disulfide WR-33278, two metabolites of the drug Ethol(WR-2721), protect DNA against fast neutron induced strand breakage 显示文摘 | Savoye C Swenberg C Hugot S | 1997 | Int J Radiat Biol1997，71，： | 1 |
| 4 | Left ventricular remodeling after anterior wall acute myocardial infaretiun in modern clinical practice (from the REmodelage VEutrieulaire study group )显示文摘 | Savoye C Equine O Tricot O | 2006 | Am J Cardiol2006，98，9： | 1 |
| 5 | An introduction to the application and future use of ^234Th in aquatic systems显示文摘 | Waples J T Benitez-Nelson C Savoye N | 2006 | Marine Chemistry2006，100，： | 1 |
| 6 | A PCR Assay Used to Study Aerosol Transmission of Actinobacillus Pleuropneumoniae From Samples of Live Pigs Under Experimental Conditions 显示文摘 | Savoye C Jobert JL | 2000 | Vet Microbiol2000，73，4： | 1 |
| 7 | Fistulizing perianal Crohn's disease: contrast-enhanced magnetic resonance imaging assessment at 1 year on maintenance anti-TNF-alpha therapy显示文摘 | Savoye-Collet C Savoye G Koning E | 2011 | Intlamm Bowel Dis2011，17，： | 1 |
| 8 | Left ventricular re- modeling alter anterior wall acute myocardial infarction in modem clinical practice (from the Remodelage Ventricu- laire study group) 显示文摘 | Savoye C Equine O Tricot O | 2006 | Am J Cardiol2006，98，9： | 1 |
| 9 | Quaternary development of migrating sediment waves in the var deep-sea fan:distribution,growth pattern,and implication for levee evolution显示文摘 | MIGEON S SAVOYE B FAUGERES J C | 2000 | Sediment Geol2000，133，： | 1 |
| 10 | Systemic infection related to endocarditis on pacemaker leads: clinical presentation and management显示文摘 | Klug D Laeroix D Savoye C | 1997 | Circulation1997，95，20： | 1 |
| 11 | Channel-mouth lobe complex ofthe recent Amazon Fan: The missing piece 显示文摘 | Jegou I Savoye B Pirmez C | 2008 | Marine Geology2008，252，12： | 1 |
| 12 | Systemic infection related to endocarditis on pacemaker leads:clinical presentation and management显示文摘 | Klug D Lacroix D Savoye C | 1997 | Circulation1997，95，8： | 1 |
| 13 | An impaired accommodation of the proximal stomach to a meal is associated with symptoms after distal gastrec- tomy显示文摘 | LE BLANC-LOUVRY I SAVOYE G MAILLOT C | 2003 | Am J Gastroenterol2003，98，12： | 1 |
| 14 | Systemic infection related to endocarditis on pacemaker leads: clinical presentation and man- agemen! 显示文摘 | King D Lacroix D Savoye C | 1997 | Circulation1997，95，8： | 1 |
| 15 | Channel-mouth lobe complex of the recent Amazon Fan:The missing piece显示文摘 | JEGOU I SAVOYE B PIRMEZ C | 2008 | Ma- rine Geology2008，252，： | 1 |
| 16 | Natural history of elderly- onset inflammatory bowel disease : a population - based cohort study 显示文摘 | Charpentier C Salleron J Savoye G | 2014 | Gut2014，63，3： | 1 |
| 17 | Defecography in symptomatic older women living at home显示文摘 | Savoye-Collet C Savoye G Koning E | 2003 | Age Ageing2003，32，3： | 1 |
| 18 | Phlegmonous gastritis in a 32-week pregnant woman managed by conservative surgical treatment and antibiotics显示文摘 | Hommel S Savoye G Lorenceau-Savale C | 2007 | Dig Dis Sci2007，52，4： | 1 |
| 19 | Comparative evaluation of a phage protein ligand assay with Real-Time PCR and a reference method for the detection of Escherichia coli O157 :H7 in raw ground beef and trimmings 显示文摘 | SAVOYE F FENG P ROZAND C | 2011 | J Food Protec2011，74，1： | 1 |
| 20 | Experimental aerosol transmission of Actinobacillus pleuropneumoniae to pigs显示文摘 | Jobert J L Savoye C Cariolet R | 2000 | Can J Vet Res2000，64，1： | 1 |
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