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| 1 | 非损伤脉冲染料激光在光子嫩肤术中和治疗炎性寻常痤疮中作用机制的调查显示文摘Background: Nonablative lasers are widely used for treatment of wrinkles, atrophic scars and acne. These lasers stimulate dermal remodelling and collagen production, but the early molecular stimulus for this is unknown. The mechanism of nonablative lasers in inflammatory acne is variously suggested to be damage either to sebaceous glands or to Propionibacterium acnes. Their effects on cytokine production are unknown. Objectives: To assess the in vivo effects of a short pulse duration nonablative pulsed-dye laser (NA-PDL) previously used for photorejuvenation and treatment of acne, on cytokine production, P. acnes colonization density and sebum excretion rate (SER). Methods: We examined the effect of NA-PDL (NliteV; Chromogenex Light Technologies, Llanelli, U.K.)-on P. acnes colonization before and after laser therapy using a scrub-wash technique and culture at 0 and 24 h (n = 15), on SER using absorptive tape at 0, 2, 4, 8 and 12 weeks (n = 19)-and on cytokine mRNA using reverse transcription-polymerase chain reaction from skin biopsies at 0, 3 and 24 h (n = 8). Results: NA-PDL had no effect on P. acnes or SER. Transforming growth factor (TGF)-β1 mRNA increased fivefold after 24 h and 15-fold in two subjects (P = 0.012). Conclusions: TGF-βis known to be a potent stimulus for neocollagenesis and a pivotal immunosuppressive cytokine which promotes inflammation resolution. Its upregulation by NA-PDL provides a possible unifying molecular mechanism linking stimulation of dermal remodelling in photorejuvenation with inhibition of inflammation in acne. Damage to P. acnes or sebaceous glands cannot explain the effect of this device in acne. | Seaton E.D. Mouser P.E. Charakida A. 周少娜 | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，，12： | 2 |
| 2 | Particulate air pollution and acute health effects显示文摘 | A. Seaton D. Godden W. MacNee K. Donaldson | 1995 | The Lancet1995，，8943： | 2 |
| 3 | Analysis of SSRs derived from grape ESTs显示文摘 | K. D. Scott P. Eggler G. Seaton M. Rossetto E. M. Ablett L. S. Lee R. J. Henry | 2000 | TAG Theoretical and Applied Genetics2000，，5： | 2 |
| 4 | Concepts of plant biotic stress: Some insights into the stress physiology of virus-infected plant from the perspective of photosynthesis 显示文摘 | Balachandran S Hurry V M Kelley S E Osmond C B Robinson S A Rohozinski J Seaton G G R Sims D A | 1997 | Physiologia Plantarum1997，100，： | 1 |
| 5 | Free radical scavengers protect dopaminergic cell lines from apoptosis induced by complex I inhibitors显示文摘 | Seaton TA Cooper JM Schapira AH | 1997 | Brain Res1997，777，12： | 1 |
| 6 | Stations, Trains and Small-world Networks显示文摘 | Seaton K Hackett L | 2004 | Physica A2004，339，3： | 1 |
| 7 | Stations, trains and small-world networks 显示文摘 | Seaton K A Hackett L M | 2004 | Physica A: Statistical Mechanics and Its Applications2004，339，34： | 1 |
| 8 | A theoretical analysis of ther-mal surface fouling 显示文摘 | Kern D Q Seaton R E | 1959 | British Chemical Engineering1959，4，5： | 1 |
| 9 | A Theoretical analysis of thermal surface fouling显示文摘 | Kern D Q Seaton R E | 1959 | Chem Eng1959，55，4： | 1 |
| 10 | Point prevalence survey of antibiotic use in Scottish hospitals utilising the Glasgow Anti- microbial AuditTool (GAAT)显示文摘 | Seaton RA Nathwani I) Burton P | 2007 | Int J Antimicrob Agents2007，29，6： | 1 |
| 11 | Surface fouling:how to limit显示文摘 | Kern D Q Seaton R E | 1959 | Br Chem Eng1959，55，6： | 1 |
| 12 | Composition dependent transport diffusion coeffients of CH4/CF4 mixtures in carbon nanotubes by non-equilibrium molecular dynamics simulations显示文摘 | Duren T Keil F J Seaton N A | 2002 | Chemical Engineering Science2002，57，8： | 1 |
| 13 | Surface Fouling: How to Limit 显示文摘 | Kern D Q Seaton R E | 1959 | Br Chem Eng1959，55，6： | 1 |
| 14 | Stations, Trains and Small-world Network 显示文摘 | Seaton K Hackett L | 2004 | Physica A2004，339，3： | 1 |
| 15 | Particulate air pollution and acute health effects 显示文摘 | A Seaton | 1995 | Lancet1995，345，8943： | 1 |
| 16 | Cyclosporin inhibition of apoptosis induced by mitochondrial complex toxins 显示文摘 | Seaton AT Cooper JM Schapira AH | 1998 | Brain Res1998，809，： | 1 |
| 17 | Direct measurement of electrical and compositional inhomogeneities in PTC thermistor 显示文摘 | Seaton J Leach C | 2004 | J Eur Ceram Soc2004，24，： | 1 |
| 18 | A new analysis method for the determination of the pore size distribution of porous car- bons from nitrogen adsorption measurements 显示文摘 | Seaton N A Walton J P R B Quirke N | 1989 | Carbon1989，6，27： | 1 |
| 19 | Analysis of SSRs derived from grape ES Ts显示文摘 | Scott K D Eggler P Seaton G | 2000 | Theor Appl Genet2000，100，5： | 1 |
| 20 | Guided by the dark: from thanatopsis to thanatourism 显示文摘 | Seaton A V | 1996 | International Journal of Heritage Studies1996，，2： | 1 |
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