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| 1 | Treatment with dimethyl fumarate ameliorates liver ischemia/reperfusion injury显示文摘AIM To investigate the hypothesis that treatment with dimethyl fumarate(D MF) mayame liorate liver ischemia/reperfusion injury(I/RI).METHODS Rats were divided into 3 groups: sham, control(CTL), and DMF. DMF(25 mg/kg, twice/d) was orally administered for 2 d before the procedure. The CTL and DMF rats were subjected to ischemia for 1 h and reperfusion for 2 h. The serum alanine aminotransferase(ALT) and malondialdehyde(MDA) levels, adenosine triphosphate(ATP), NO × metabolites, anti-oxidant enzyme expression level, antiinflammatory effect, and anti-apoptotic effect were determined.RESULTS Histological tissue damage was significantly reduced in the DMF group(Suzuki scores: sham: 0 ± 0; CTL: 9.3± 0.5; DMF: 2.5 ± 1.2; sham vs CTL, P < 0.0001; CTL vs DMF, P < 0.0001). This effect was associated with significantly lower serum ALT(DMF 5026 ± 2305 U/L vs CTL 10592 ± 1152 U/L, P = 0.04) and MDA(DMF 18.2 ± 1.4 μmol/L vs CTL 26.0 ± 1.0 μmol/L, P = 0.0009). DMF effectively improved the ATP content(DMF 20.3 ± 0.4 nmol/mg vs CTL 18.3 ± 0.6 nmol/mg, P = 0.02), myeloperoxidase activity(DMF 7.8 ± 0.4 m U/m L vs CTL 6.0 ± 0.5 m U/m L, P = 0.01) and level of endothelial nitric oxide synthase expression(DMF 0.38 ± 0.05-fold vs 0.17 ± 0.06-fold, P = 0.02). The higher expression levels of anti-oxidant enzymes(catalase and glutamatecysteine ligase modifier subunit and lower levels of key inflammatory mediators(nuclear factor-kappa B and cyclooxygenase-2 were confirmed in the DMF group.CONCLUSION DMF improved the liver function and the anti-oxidant and inflammation status following I/RI. Treatment with DMF could be a promising strategy in patients with liver I/RI. | Chie Takasu Nosratola D Vaziri Shiri Li Lourdes Robles Kelly Vo Mizuki Takasu Christine Pham Seyed H Farzaneh Mitsuo Shimada Michael J Stamos Hirohito Ichii | 2017 | World Journal of Gastroenterology2017，23，25： | 3 |
| 2 | Effect of interlamellar spacing on cementite dissolution during wire drawing of pearlitic steel wires显示文摘 | Wong Jong Nam Chul Min Bae Sei J Oh Soon-Ju Kwon | 2000 | Scripta Materialia2000，，5： | 2 |
| 3 | Effect of interlamellar spacing on cementite dissolution during wire drawing of pearlitic steel wires显示文摘 | Wong Jong Nam Chul Min Bae Sei J Oh | 2000 | Set Mater2000，42，： | 1 |
| 4 | Association of small vessel disease with dilatative arteriopath of the brain:neuropathologic evidence显示文摘 | Pico F Labreuche J Sei Ihean D | 2007 | Stroke2007，38，9： | 1 |
| 5 | Multi-product production quantity model with repair failure and partial backordering显示文摘 | ATA A T WEE H M SEYED J S | 2010 | Computers and Industrial Engineering2010，59，1： | 1 |
| 6 | Vehicle routing problem with uncertain demands:An advanced particle swarm algorithm显示文摘 | Babak F M Rubén R Seyed J S | 2011 | Computers Industrial Engineering2011，62，1： | 1 |
| 7 | Atmospheric cor rosion of different steels in marine, rural and industri al environments 显示文摘 | Sei J O Cook D C Townsend H E | 1999 | Corrosion Science1999，，： | 1 |
| 8 | Effects of thawing methods on chemical, biochemical, and microbial quality of frozen whole rainbow trout (oncorhynchus mykiss ) 显示文摘 | Seyed R J Masoud R Mahdi S | 2013 | Journal of Aquatic Food Product Technology2013，22，2： | 1 |
| 9 | Outcomes of the Rives-Stoppa technique in incisional hernia repair:ten years of experience显示文摘 | Yaghoobi Notash A Yaghoobi Notash A Jr Seied Farshi J | 2007 | Hernia2007，11，1： | 1 |
| 10 | Optimal production planning显示文摘 | Seyed J | 1996 | OR/MS Today1996，，4： | 1 |
| 11 | Efects of conjugatedlinoleic acid isomers on lipid-metablolizing enzymes in male rats显示文摘 | Martin J Gregoire S Seis M | 2000 | Lipids2000，35，： | 1 |
| 12 | Direct identification of Vibrio vulnificus in clinical specimens by nested PCR 显示文摘 | Hee E L Soo Y K Sei J K | 1998 | Journal of Clinical Microbiology1998，36，10： | 1 |
| 13 | NS a coordinator of self- renewal, is expressed in rat marrow stromal cells and turns off after induction of neural differentiation 显示文摘 | Mohammad M Y Seyed J M Taki T | 2005 | Neurosei lett2005，390，2： | 1 |
| 14 | Fib~blast growth factor receptor ] gene expression is required for cardiomyocyte proliferation and is repressed by Sp3 显示文摘 | Seyed M DiMario J X | 2008 | Journal of Molecular and Cellular Cardiology2008，44，3： | 1 |
| 15 | The G-protein-coupled receptor GPR40 directly mediates long-chain fatty acid-induced secretion of cholecystokinin显示文摘 | Liou A P Lu XP Sei Y Zhao XL Pechhold S Carrero R J Raybould H E Wank S | | 0，，03： | 1 |
| 16 | Target specific and long-acting delivery of protein, peptide, and nucleotide therapeutics using hyaluronic acid derivatives显示文摘 | Eun J O Kitae P Ki S K Jiseok K Jeong A Yang Ji H K Min Y L Allan S H Sei K H | 2010 | Journal of Controlled Release2010，141，1： | 1 |
| 17 | Atmospheric corrosion of different steels in marine,rural and industrial environments显示文摘 | Sei J Oh Cook D C Townsend H E | 1998 | Corrosion Science1998，41，： | 1 |
| 18 | A HER2-targeted RNA aptamer molecule labeled with 99mTc for single-photon显示文摘 | Varmira k Seyed A Hosseinimehr J | 2013 | Nucl Med Biol2013，40，： | 1 |
| 19 | Reliability-based simulation optimization model for multi-reservoir hydropower systems operations : khersan experience 显示文摘 | Raheleh A Seyed J M Abbas G | 2008 | Journal of Water Resources Planning and Management2008，134，1： | 1 |
| 20 | An improved radiolabelled RNA aptamer molecule for HER2 imaging显示文摘 | Kambiz V Seyed J Hosseinimehr ZN | 2014 | J Drug Target2014，2，： | 1 |
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