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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | CD44 and its partners in metastasis 显示文摘 | Serge J | 2003 | Clinical & Experimental Metastasis2003，20，4： | 1 |
| 3 | Polymer nanocomposites: How to reach low flammability 显示文摘 | Serg B Sophie D Charaf J | 2006 | Macromolecular Symposia2006，233，1： | 1 |
| 4 | Nebivolol and metoprolol: long- term effects on inflammation and oxidative stress in es- sentialhypertension显示文摘 | Serg M Kampus P Kals J | 2012 | Scand J Clin Lab Invest2012，72，5： | 1 |
| 5 | Differential effects of nebivolol and metoprolol on central aortic pressure and left ventricular wall thickness 显示文摘 | Kampus P Serg M Kals J | 2011 | Hypertension2011，57，6： | 1 |
| 6 | Differential effects of nebivolol and metoprolol on central aortic pressure and left ventricular wall thickness显示文摘 | Kampus P Serg M Kals J | 2011 | Hypertension2011，57，6： | 1 |
| 7 | Cardiac Angiography in renally impaired patitient(CARE) study:a randomized double-blind trial of contras-induced nephropathy in patients with chronic kidney disease显示文摘 | Richard J Madhu K Serge Doucet | 2007 | Circulation2007，115，： | 1 |
| 8 | Effectiveness of block copolymers as sta- bilizers for aqueous titanium dioxide dispersions of a high solid content 显示文摘 | Serge C Robert J | 2000 | Prog Org Coat2000，40，1： | 1 |
| 9 | Spectral elec- tromyography assessment of back muscles in patients with low back pain undergoing rehabilitation 显示文摘 | Serge H R Carlo J D Mark E B S | 1995 | Spine1995，20，1： | 1 |
| 10 | Differential effects of nebivolo! and metoprolol on central aortic pressure and left ventricular wall thickness显示文摘 | Kampus P Serg M Kals J ecal | 2011 | Hypertension2011，57，6： | 1 |
| 11 | Differential effects of nebivolol and metoprolol on central aortic pressure and left ventricular wall thickness显示文摘 | Kampus P Serg M Kals J | 2011 | Hypertension2011，57，6： | 1 |
| 12 | Production of synthetic natural gas (SNG) from coal and dry biomass -Atechnology review from 1950 to 2009显示文摘 | Jan Kopyscinski Tilman J S Serge M A B | 2010 | Fuel2010，89，8： | 1 |
| 13 | Simulating climate change impacts on fire frequency and vegetation dynamics in a Mediterranean-type ecosystem 显示文摘 | FLORENT M SERGE R RICHARD J | 2002 | Global Change Biology2002，8，： | 1 |
| 14 | Methanation in a fluidized bed reactor with high initial CO partial pressure: Part I-Experimental investigation of hydrodynamics, mass transfer effects, and carbon deposition显示文摘 | Jan Kopyscinski Tilman J S Serge M A B | 2011 | Chemical Engineering Science2011，66，5： | 1 |
| 15 | Influence of culti-var,maturity storage,and storage conditions on phe-nolic composition and enzymatic browning of pear fruits显示文摘 | Marie J A Max T Serge Y A | | 0，，： | 1 |
| 16 | Nebivolol and metoprolol:long-termeffects on inflammation and oxidative stress in essential hypertension显示文摘 | Serg M Kampus P Kals J | | 0，，： | 1 |
| 17 | Nebivolol and metopro- lo1: long-term effects on inflammation and oxidative stress in essential hypertension 显示文摘 | Serg M Kampus P Kals J | 2012 | Scand J Clin Lab Invest2012，72，5： | 1 |
| 18 | Simulating climate change impacts on fire frequency and vegetation dynamics in a Mediterranean - type ecosystem显示文摘 | Florent M Serge R Richard J | 2002 | Global Change Biology2002，8，5： | 1 |
| 19 | Differential effects of nebivolol and metoprolol on central aortic pressure and left ventricular wall thickness 显示文摘 | Kampus P Serg M Kals J | 2011 | Hypertension2011，57，6： | 1 |
| 20 | Fluidized bed methanation of wood-derived producer gas for the production of synthetic natural gas显示文摘 | Marin C S Tilman J S Serge M A B | 2010 | Industry Enginering and Chemistry Research2010，49，15： | 1 |
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